scholarly journals LOWER SERUM FSH LEVELS IN RESPONSE TO IV RECOMBINANT FSH IN OBESE WOMEN IS NOT EXPLAINED BY GNRH ANTAGONIST (CETRORELIX) PHARMACODYNAMICS

2020 ◽  
Vol 114 (3) ◽  
pp. e8
Author(s):  
Katherine Kuhn ◽  
Thanh Ha Luu ◽  
Andrew P. Bradford ◽  
Luke Wittenburg ◽  
Nne-Omoji Nwobodo ◽  
...  
Keyword(s):  
Gnrh Antagonist ◽  
Recombinant Fsh ◽  
Obese Women ◽  
Lower Serum

scholarly journals Gonadotropins Regulate Rat Testicular Tight Junctions in Vivo

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2911-2922 ◽  
Author(s):  
Mark J. McCabe ◽  
Gerard A. Tarulli ◽  
Sarah J. Meachem ◽  
David M. Robertson ◽  
Peter M. Smooker ◽  
...  
Keyword(s):  
Tight Junctions ◽  
Sertoli Cell ◽  
Gnrh Antagonist ◽  
Hormone Replacement ◽  
Recombinant Fsh ◽  
Short Term ◽  
Adult Rat ◽  
Serum Androgens

Sertoli cell tight junctions (TJs) are an essential component of the blood-testis barrier required for spermatogenesis; however, the role of gonadotropins in their maintenance is unknown. This study aimed to investigate the effect of gonadotropin suppression and short-term replacement on TJ function and TJ protein (occludin and claudin-11) expression and localization, in an adult rat model in vivo. Rats (n = 10/group) received the GnRH antagonist, acyline, for 7 wk to suppress gonadotropins. Three groups then received for 7 d: 1) human recombinant FSH, 2) human chorionic gonadotropin (hCG) and rat FSH antibody (to study testicular androgen stimulation alone), and 3) hCG alone (to study testicular androgen and pituitary FSH production). TJ proteins were assessed by real-time PCR, Western blot analysis, and immunohistochemistry, whereas TJ function was assessed with a biotin permeation tracer. Acyline treatment significantly reduced testis weights, serum androgens, LH and FSH, and adluminal germ cells (pachytene spermatocyte, round and elongating spermatids). In contrast to controls, acyline induced seminiferous tubule permeability to biotin, loss of tubule lumens, and loss of occludin, but redistribution of claudin-11, immunostaining. Short-term hormone replacement stimulated significant recoveries in adluminal germ cell numbers. In hCG ± FSH antibody-treated rats, occludin and claudin-11 protein relocalized at the TJ, but such relocalization was minimal with FSH alone. Tubule lumens also reappeared, but most tubules remained permeable to biotin tracer, despite the presence of occludin. It is concluded that gonadotropins maintain Sertoli cell TJs in the adult rat via a mechanism that includes the localization of occludin and claudin-11 at functional TJs.

Evidence of GNRH antagonist escape in obese women: potential explanation for the high assisted reproductive technology cancellation rate

2013 ◽  
Vol 100 (3) ◽  
pp. S134-S135
Author(s):  
L.W. Roth ◽  
E.L. Bradshaw-Pierce ◽  
A.A. Allshouse ◽  
J. Chosich ◽  
A.J. Polotsky ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Gnrh Antagonist ◽  
Reproductive Technology ◽  
Obese Women ◽  
Potential Explanation ◽  
Cancellation Rate

Pharmacokinetics of GnRH antagonist altered in obese women

2014 ◽  
Vol 1497 (1) ◽  
pp. 4-4
Keyword(s):  
Gnrh Antagonist ◽  
Obese Women

Elevated serum progesterone at end of stimulation with recombinant FSH, but not with highly purified menotropin, is associated with poor outcome in GnRH antagonist cycles

2011 ◽  
Vol 96 (3) ◽  
pp. S54
Author(s):  
E. Bosch ◽  
B. Urman ◽  
J. Smitz ◽  
B.M. Klein ◽  
J.-C. Arce
Keyword(s):  
Gnrh Antagonist ◽  
Elevated Serum ◽  
Recombinant Fsh ◽  
Serum Progesterone ◽  
Poor Outcome
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