SIMULATED LONG-TERM EFFECTS OF RELUGOLIX COMBINATION THERAPY ON BONE MINERAL DENSITY AT THE LUMBAR SPINE AS PREDICTED BY A VALIDATED SEMI-MECHANISTIC EXPOSURE-RESPONSE MODEL

2020 ◽  
Vol 114 (3) ◽  
pp. e350
Author(s):  
Anthe S. Zandvliet ◽  
Aziz Ouerdani ◽  
Tien-Yi Lee ◽  
Elizabeth M. Migoya ◽  
Juan Camilo Arjona Ferreira ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Combination Therapy ◽  
Bone Mineral ◽  
Response Model ◽  
Long Term Effects ◽  
Mineral Density ◽  
Exposure Response

scholarly journals Trajectories of Bone Remodeling Markers and Bone Mineral Density during Treatment with Strontium Ranelate in Postmenopausal Women Previously Treated with Bisphosphonates

2014 ◽  
Vol 7 ◽  
pp. CMED.S15086 ◽  
Author(s):  
Helisane Lima ◽  
Juliana Maia ◽  
Francisco Bandeira
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Strontium Ranelate ◽  
Mineral Density ◽  
Bone Remodeling Markers ◽  
Before And After ◽  
Previously Treated

Objective To evaluate the responses of C-terminal telopeptide (CTX) and serum osteocalcin after the first 4 months of treatment with strontium ranelate (SR) and demonstrate their association with long-term bone density changes. Subjects and Methods A sample of 13 postmenopausal women with osteoporosis was analyzed (mean age 65 ± 7.7 years), who were treated with SR for an average of 2.56 ± 0.86 years. All patients had undergone previous treatment with bisphosphonates for an average period of 4.88 ± 2.27 years. Serum CTX and osteocalcin levels were determined before and after four months of treatment with SR. Bone mineral density in the lumbar spine and femoral neck were obtained before and after treatment with SR. Results We observed an average increase of 53.7% in the CTX levels, and 30.7% in the osteocalcin levels. The increase in bone markers was associated with a mean 4.8% increase in lumbar spine bone mineral density (BMD) from 0.820 to 0.860 g/cm2 ( T-score from –2.67 to –1.92; P= 0.001), after 2.5 years of treatment with SR. Conclusion These data suggest an anabolic effect of SR on postmenopausal women who were previously treated with long-term bisphosphonates.

Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women

Metabolism ◽  
2011 ◽  
Vol 60 (9) ◽  
pp. 1211-1221 ◽  
Author(s):  
Elizabeth Sienkiewicz ◽  
Faidon Magkos ◽  
Konstantinos N. Aronis ◽  
Mary Brinkoetter ◽  
John P. Chamberland ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Mineral Density

Nafarelin therapy in endometriosis: Long-term effects on bone mineral density

1994 ◽  
Vol 171 (5) ◽  
pp. 1221-1225 ◽  
Author(s):  
Eric S. Orwoll ◽  
A. Albert Yuzpe ◽  
Kenneth A. Burry ◽  
Leroy Heinrichs ◽  
Veasy C. Buttram ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Long Term Effects ◽  
Mineral Density

scholarly journals Long-term effects of anastrozole on bone mineral density: 7-year results from the ATAC trial

2011 ◽  
Vol 22 (4) ◽  
pp. 857-862 ◽  
Author(s):  
R. Eastell ◽  
J. Adams ◽  
G. Clack ◽  
A. Howell ◽  
J. Cuzick ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Long Term Effects ◽  
Mineral Density

scholarly journals INTEGRATED LONG-TERM BONE MINERAL DENSITY (BMD) OUTCOMES IN WOMEN RECEIVING RELUGOLIX COMBINATION THERAPY IN LIBERTY AND SPIRIT STUDIES VS NON-TREATED WOMEN

2021 ◽  
Vol 116 (3) ◽  
pp. e50
Author(s):  
Michael R. McClung ◽  
Arthur C. Santora ◽  
Ayman Al-Hendy ◽  
Neil Johnson ◽  
Steven R. Cummings ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Combination Therapy ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Long-Term Effects in Bone Mineral Density after Different Bariatric Procedures in Patients with Type 2 Diabetes: Outcomes of a Randomized Clinical Trial

2020 ◽  
Vol 9 (6) ◽  
pp. 1830 ◽  
Author(s):  
Fernando Guerrero-Pérez ◽  
Anna Casajoana ◽  
Carmen Gómez-Vaquero ◽  
Nuria Virgili ◽  
Rafael López-Urdiales ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
First Year ◽  
Gastrointestinal Hormone ◽  
Long Term Effects ◽  
Mineral Density ◽  
Greater Curvature

There is scant evidence of the long-term effects of bariatric surgery on bone mineral density (BMD). We compared BMD changes in patients with severe obesity and type 2 diabetes (T2D) 5 years after randomization to metabolic gastric bypass (mRYGB), sleeve gastrectomy (SG) and greater curvature plication (GCP). We studied the influence of first year gastrointestinal hormone changes on final bone outcomes. Forty-five patients, averaging 49.4 (7.8) years old and body mass index (BMI) 39.4 (1.9) kg/m2, were included. BMD at lumbar spine (LS) was lower after mRYGB compared to SG and GCP: 0.89 [0.82;0.94] vs. 1.04 [0.91;1.16] vs. 0.99 [0.89;1.12], p = 0.020. A higher percentage of LS osteopenia was present after mRYGB 78.6% vs. 33.3% vs. 50.0%, respectively. BMD reduction was greater in T2D remitters vs. non-remitters. Weight at fifth year predicted BMD changes at the femoral neck (FN) (adjusted R2: 0.3218; p = 0.002), and type of surgery (mRYGB) and menopause predicted BMD changes at LS (adjusted R2: 0.2507; p < 0.015). In conclusion, mRYGB produces higher deleterious effects on bone at LS compared to SG and GCP in the long-term. Women in menopause undergoing mRYGB are at highest risk of bone deterioration. Gastrointestinal hormone changes after surgery do not play a major role in BMD outcomes.

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