Distribution of aerosol paint droplets in open- and closed-space environments: Towards activity level evaluation

2020 ◽  
Vol 306 ◽  
pp. 110065
Author(s):  
Mylène Falardeau ◽  
Cyril Muehlethaler
1994 ◽  
Author(s):  
Gail Brion ◽  
Charles P. Gerba ◽  
JoAnn Silverstein

2018 ◽  
Author(s):  
Santosh Vijapur ◽  
Tim Hall ◽  
Jennings E. Taylor ◽  
DAN WANG ◽  
Maria Inman ◽  
...  

Novel technologies with limited earth support are required to enable energy-efficient maintenance of closed air, water, and waste systems in microgravity spacecraft habitats such as International space station (ISS). One area of need for the interstellar travel community is cleaning/sanitizing supplies to meet personal hygiene requirements, which is currently accomplished through the use of pre-packaged, disposable, wetted wipes, or ion exchange cartridges. These items represent an appreciable carry-along mass and disposal/replacement burden requiring earth based support. Therefore, if a system could be developed to use onboard utilities to create cleaning and disinfecting solutions it would reduce the astronaut’s dependence on earth based supplies.We are addressing this challenge by demonstrating a technology that will use utilities on-board the spacecraft habitat to create sanitizing solutions and eliminate the need for regular delivery of disinfecting wipes. This concept is founded on the electrochemical reduction of oxygen to hydrogen peroxide using readily available on-board supplies of O2 and water. Peroxide is well-established disinfectant with non-toxic decomposition products (viz., O2 and H2O), that is safe enough for human contact to be sold commercially as a 3% w/w solution. Thus, it is an ideal disinfecting solution for closed space environments.


2020 ◽  
Vol 64 (2) ◽  
pp. 325-336 ◽  
Author(s):  
Dimitriya H. Garvanska ◽  
Jakob Nilsson

Abstract Kinetochores are instrumental for accurate chromosome segregation by binding to microtubules in order to move chromosomes and by delaying anaphase onset through the spindle assembly checkpoint (SAC). Dynamic phosphorylation of kinetochore components is key to control these activities and is tightly regulated by temporal and spatial recruitment of kinases and phosphoprotein phosphatases (PPPs). Here we focus on PP1, PP2A-B56 and PP2A-B55, three PPPs that are important regulators of mitosis. Despite the fact that these PPPs share a very similar active site, they target unique ser/thr phosphorylation sites to control kinetochore function. Specificity is in part achieved by PPPs binding to short linear motifs (SLiMs) that guide their substrate specificity. SLiMs bind to conserved pockets on PPPs and are degenerate in nature, giving rise to a range of binding affinities. These SLiMs control the assembly of numerous substrate specifying complexes and their position and binding strength allow PPPs to target specific phosphorylation sites. In addition, the activity of PPPs is regulated by mitotic kinases and inhibitors, either directly at the activity level or through affecting PPP–SLiM interactions. Here, we discuss recent progress in understanding the regulation of PPP specificity and activity and how this controls kinetochore biology.


1997 ◽  
Vol 13 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Marit Sorensen

Adherence to lifestyle changes - beginning to exercise, for example - is assumed to be mediated by self-referent thoughts. This paper describes a pilot study and three studies conducted to develop and validate a questionnaire for adults to determine their self-perceptions related to health-oriented exercise. The pilot study identified items pertinent to the domains considered important in this context, and began the process of selecting items. Study 2 examined the factor structure, reduced the number of items, determined the internal consistency of the factors, and explored the discriminative validity of the questionnaire as to physical activity level and gender. Four factors with a total of 24 items were accepted, measuring mastery of exercise, body perception, social comfort/discomfort in the exercise setting, and perception of fitness. All subscales had acceptable internal consistencies. Preliminary validity was demonstrated by confirming hypothesized differences in scores as to gender, age, and physical activity level. The third study examined and demonstrated convergent validity with similar existing subscales. The fourth study examined an English-language version of the questionnaire, confirming the existence of the factors and providing preliminary psychometric evidence of the viability of the questionnaire.


2011 ◽  
Author(s):  
Jan Warren-Findlow ◽  
Rachel B. Seymour

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