Glucocorticoid Resistance in Lymphoma Cells Mediated by Hydrogen Peroxide Removal and Disregulation of MAPK Signaling

2010 ◽  
Vol 49 ◽  
pp. S131
Author(s):  
Margaret E. Tome ◽  
Melba C. Jaramillo ◽  
Margaret M. Briehl
Keyword(s):  
Hydrogen Peroxide ◽  
Mapk Signaling ◽  
Glucocorticoid Resistance ◽  
Lymphoma Cells ◽  
Peroxide Removal

Impairment of photosynthetic capacity and hydrogen peroxide removal in castor bean affected by bacterial leaf spot

2020 ◽  
Vol 111 ◽  
pp. 101510
Author(s):  
Priscilla Aguiar Möller ◽  
Carlos Eduardo Aucique-Pérez ◽  
Andersom Milech Einhardt ◽  
Diego Campos Lemos ◽  
Fabrício Ávila Rodrigues ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Leaf Spot ◽  
Castor Bean ◽  
Photosynthetic Capacity ◽  
Bacterial Leaf Spot ◽  
Peroxide Removal

scholarly journals Hydrogen Sulfide Attenuates Hydrogen Peroxide-Induced Injury in Human Lung Epithelial A549 Cells

2019 ◽  
Vol 20 (16) ◽  
pp. 3975 ◽  
Author(s):  
Mingqi Wang ◽  
Xinyu Cao ◽  
Chang Luan ◽  
Zhengqiang Li
Keyword(s):  
Hydrogen Peroxide ◽  
Hydrogen Sulfide ◽  
Lung Injury ◽  
Er Stress ◽  
Human Lung ◽  
A549 Cells ◽  
Mapk Signaling ◽  
Protective Mechanism ◽  
Lung Epithelial ◽  
Pre Treatment

Lung tissues are frequently exposed to a hyperoxia environment, which leads to oxidative stress injuries. Hydrogen sulfide (H2S) is widely implicated in physiological and pathological processes and its antioxidant effect has attracted much attention. Therefore, in this study, we used hydrogen peroxide (H2O2) as an oxidative damage model to investigate the protective mechanism of H2S in lung injury. Cell death induced by H2O2 treatment could be significantly attenuated by the pre-treatment of H2S, resulting in a decrease in the Bax/Bcl-2 ratio and the inhibition of caspase-3 activity in human lung epithelial cell line A549 cells. Additionally, the results showed that H2S decreased reactive oxygen species (ROS), as well as neutralized the damaging effects of H2O2 in mitochondria energy-producing and cell metabolism. Pre-treatment of H2S also decreased H2O2-induced suppression of endogenous H2S production enzymes, cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercapto-pyruvate sulfurtransferase (MPST). Furthermore, the administration of H2S attenuated [Ca2+] overload and endoplasmic reticulum (ER) stress through the mitogen-activated protein kinase (MAPK) signaling pathway. Therefore, H2S might be a potential therapeutic agent for reducing ROS and ER stress-associated apoptosis against H2O2-induced lung injury.

scholarly journals Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells

2011 ◽  
Vol 51 (11) ◽  
pp. 2048-2059 ◽  
Author(s):  
Margaret E. Tome ◽  
Melba C. Jaramillo ◽  
Margaret M. Briehl
Keyword(s):  
Hydrogen Peroxide ◽  
Lymphoma Cells ◽  
Induced Apoptosis

Hydrogen Peroxide Removal with Magnetically ResponsiveSaccharomyces cerevisiaeCells

2008 ◽  
Vol 56 (17) ◽  
pp. 7925-7928 ◽  
Author(s):  
Ivo Safarik ◽  
Zdenka Sabatkova ◽  
Mirka Safarikova
Keyword(s):  
Hydrogen Peroxide ◽  
Peroxide Removal

scholarly journals Contribution of S6K1/MAPK Signaling Pathways in the Response to Oxidative Stress: Activation of RSK and MSK by Hydrogen Peroxide

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75523 ◽  
Author(s):  
Anna Siebel ◽  
Monica Cubillos-Rojas ◽  
Roberto Christ Santos ◽  
Taiane Schneider ◽  
Carla Denise Bonan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Stress Activation ◽  
Mapk Signaling Pathways
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