Tumor microenvironment and oxidative stress: involvement in metabolic reprogramming and chemo-resistance of prostate cancer cells

2012 ◽  
Vol 53 ◽  
pp. S51 ◽  
Author(s):  
M.L. Taddei ◽  
T. Fiaschi ◽  
A. Marini ◽  
V. Farini ◽  
S. Stinziani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Metabolic Reprogramming ◽  
Prostate Cancer Cells ◽  
And Oxidative Stress

OXIDATIVE STRESS IS INHERENT IN PROSTATE CANCER CELLS AND MEDIATES AGGRESSIVE PHENOTYPE

2008 ◽  
Vol 179 (4S) ◽  
pp. 192-193 ◽  
Author(s):  
Binod Kumar ◽  
Sweaty Koul ◽  
Lakshmipathi Khandrika ◽  
Randall B Meacham ◽  
Hari K Koul
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Aggressive Phenotype

scholarly journals Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells

2010 ◽  
Vol 70 (11) ◽  
pp. 4560-4568 ◽  
Author(s):  
Farideh Mehraein-Ghomi ◽  
Hirak S. Basu ◽  
Dawn R. Church ◽  
F. Michael Hoffmann ◽  
George Wilding
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Stress Generation ◽  
Prostate Cancer Cells

scholarly journals The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells

The Prostate ◽  
2011 ◽  
Vol 72 (6) ◽  
pp. 612-625 ◽  
Author(s):  
Alexandra M. Fajardo ◽  
Debra A. MacKenzie ◽  
Ming Ji ◽  
Lorraine M. Deck ◽  
David L. Vander Jagt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Curcumin Analog

Abstract 2083: The stress oncoprotein LEDGF/p75 attenuates oxidative stress-induced necrosis but not apoptosis in prostate cancer cells

2011 ◽  
Author(s):  
Lai Sum Leoh ◽  
Melanie Mediavilla-Varela ◽  
Anamika Basu ◽  
Tracy R. Daniels ◽  
Shannalee Martinez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells

Abstract 1467: Metabolic reprogramming fuels prostate cancer cells towards enzalutamide resistance

2020 ◽  
Author(s):  
Shiv S. Verma ◽  
Eswar Shankar ◽  
Rajnee Kanwal ◽  
Ricky Chan ◽  
Sanjay Gupta
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Metabolic Reprogramming ◽  
Prostate Cancer Cells

scholarly journals ERβ and NFκB—Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells

Toxins ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 199 ◽  
Author(s):  
Karolina Kowalska ◽  
Dominika Ewa Habrowska-Górczyńska ◽  
Kamila Domińska ◽  
Kinga Anna Urbanek ◽  
Agnieszka Wanda Piastowska-Ciesielska
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
M Cell ◽  
Androgen Independence ◽  
Prostate Carcinogenesis ◽  
Cycle Arrest ◽  
Light Chain Enhancer

Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is commonly expressed in prostate cancer (PCa) cells and is associated with increased proliferation, metastases and androgen independence. Zearalenone (ZEA) is one of the most common mycotoxins contaminating food, which might mimic estrogens and bind to estrogen receptors (ERs). The ratio of androgens to estrogens in men decreases physiologically with age, and is believed to participate in prostate carcinogenesis. In this study, we evaluated the role of NFκB and ERβ in the induction of oxidative stress in human PCa cells by ZEA. As observed, ZEA at a dose of 30 µM induces oxidative stress in PCa cells associated with DNA damage and G2/M cell cycle arrest. We also observed that the inhibition of ERβ and NFΚB via specific inhibitors (PHTPP and BAY 117082) significantly increased ZEA-induced oxidative stress, although the mechanism seems to be different for androgen-dependent and androgen-independent cells. Based on our findings, it is possible that the activation of ERβ and NFΚB in PCa might protect cancer cells from ZEA-induced oxidative stress. We therefore shed new light on the mechanism of ZEA toxicity in human cells.

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