Drug-induced effects on urea cycle enzymes associate with altered ammonia metabolism, NAD + biosynthesis and mitochondrial protein acetylome

2018 ◽  
Vol 120 ◽  
pp. S108
Author(s):  
Marco F Moedas ◽  
Mafalda Farelo ◽  
João Caio ◽  
Antonina Pereira ◽  
Lodewijk IJlst ◽  
...  
Keyword(s):  
Urea Cycle ◽  
Mitochondrial Protein ◽  
Drug Induced ◽  
Ammonia Metabolism ◽  
Nad Biosynthesis ◽  
Urea Cycle Enzymes

Hepatic ammonia metabolism in a uricotelic treefrog Phyllomedusa sauvagei

1984 ◽  
Vol 246 (5) ◽  
pp. R805-R810 ◽  
Author(s):  
J. W. Campbell ◽  
J. E. Vorhaben ◽  
D. D. Smith
Keyword(s):  
Uric Acid ◽  
Urea Cycle ◽  
Liver Mitochondria ◽  
Synthetase Activity ◽  
Mitochondrial Enzyme ◽  
Ammonia Metabolism ◽  
Carbamoylphosphate Synthetase ◽  
High Degree ◽  
Isolated Liver ◽  
Urea Cycle Enzymes

Glutamine synthetase, a mitochondrial enzyme in liver of uricotelic reptiles and birds, is present in the cytosolic compartment of Phyllomedusa sauvagei liver. The average level is sufficient to account for the rate of uric acid excretion by adult frogs but is far lower than that present in birds and reptiles. Except for lower carbamoylphosphate synthetase activity, the activities of the urea cycle enzymes in P. sauvagei liver are comparable with those in adult ureotelic amphibians. The subcellular distribution of the urea cycle enzymes is much the same as in ureotelic amphibians and mammals with the possible exception of the occurrence of a small percentage of the carbamoylphosphate synthetase and ornithine transacarbamylase activities in the cytosol. In keeping with the subcellular localization of the enzymes, citrulline, and not glutamine, is formed by isolated liver mitochondria. The rapid degradation of glutamine by these mitochondria suggests a high degree of compartmentation of glutamine in the cytosol of P. sauvagei if it is to function as a precursor of uric acid in this compartment.

Pathogenesis of Reye's Syndrome: A Working Hypothesis

PEDIATRICS ◽  
1975 ◽  
Vol 56 (6) ◽  
pp. 1081-1084
Author(s):  
M. Michael Thaler
Keyword(s):  
Fatty Liver ◽  
Intracellular Transport ◽  
Urea Cycle ◽  
Transport Mechanisms ◽  
Reye's Syndrome ◽  
Specific Therapy ◽  
Ammonia Metabolism ◽  
History Of ◽  
Urea Cycle Enzymes

The brief history of Reye's syndrome has been one of progressive familiarity with a deepening mystery. It is possible that the syndrome reflects a variety of etiologically unrelated conditions with similar clinicopathological manifestations. In this view, subclinical defects in ammonia metabolism may constitute a distinct, identifiable group among disorders responsible for encephalopathy with fatty liver. Awareness of the possible role of mutant urea cycle enzymes and deficient substrates in the pathogenesis of this important illness should stimulate investigations of enzyme kinetics and intracellular transport mechanisms which may reveal a spectrum of abnonmalities in ammonia metabolism-and a specific therapy for each.

scholarly journals Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription.

1992 ◽  
Vol 267 (8) ◽  
pp. 5032-5035
Author(s):  
M Horiuchi ◽  
K Kobayashi ◽  
M Tomomura ◽  
M Kuwajima ◽  
Y Imamura ◽  
...  
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Enzymes

Citrulline Levels and Urea Cycle Enzymes in Uremic Rats

1974 ◽  
Vol 104 (6) ◽  
pp. 678-683 ◽  
Author(s):  
Winnie Chan ◽  
Marian Wang ◽  
Joel D. Kopple ◽  
Marian E. Swendseid
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Enzymes

Gene expression of urea cycle enzymes following two-thirds partial hepatectomy in the rat

1995 ◽  
Vol 22 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Niels Tygstrup ◽  
Søren Bak ◽  
Bjørg Krog ◽  
Antonello Pietrangelo ◽  
David A. Shafritz
Keyword(s):  
Gene Expression ◽  
Partial Hepatectomy ◽  
Urea Cycle ◽  
Urea Cycle Enzymes
Sign in / Sign up

Export Citation Format

Share Document