Molecular characterization, expression and function analysis of a five-domain Kazal-type serine proteinase inhibitor from pearl oyster Pinctada fucata

2014 ◽  
Vol 37 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Dianchang Zhang ◽  
Jianjun Ma ◽  
Shigui Jiang
Keyword(s):  
Molecular Characterization ◽  
Proteinase Inhibitor ◽  
Function Analysis ◽  
Serine Proteinase ◽  
Pearl Oyster ◽  
Pinctada Fucata ◽  
Serine Proteinase Inhibitor ◽  
And Function

Molecular characterization of two kazal-type serine proteinase inhibitor genes in the surf clam Mesodesma donacium exposed to Vibrio anguillarum

2013 ◽  
Vol 34 (6) ◽  
pp. 1448-1454 ◽  
Author(s):  
Waleska Maldonado-Aguayo ◽  
Gustavo Núñez-Acuña ◽  
Valentina Valenzuela-Muñoz ◽  
Jacqueline Chávez-Mardones ◽  
Cristian Gallardo-Escárate
Keyword(s):  
Molecular Characterization ◽  
Proteinase Inhibitor ◽  
Vibrio Anguillarum ◽  
Serine Proteinase ◽  
Serine Proteinase Inhibitor ◽  
Surf Clam ◽  
Inhibitor Genes

Histone H4: Genomic identification and function analysis in pearl oyster Pinctada fucata martensii

2021 ◽  
Author(s):  
Shuai Yang ◽  
Xiaoyan Pan ◽  
Yanfei Cao ◽  
Xiaowen Lu ◽  
Yu Jiao
Keyword(s):  
Function Analysis ◽  
Pearl Oyster ◽  
Pinctada Fucata ◽  
Histone H4 ◽  
And Function

HSP40 gene family in pearl oyster Pinctada fucata martensii: Genome-Wide identification and function analysis

2019 ◽  
Vol 93 ◽  
pp. 904-910
Author(s):  
Qingheng Wang ◽  
Wenlu Wei ◽  
Ya Liu ◽  
Zhe Zheng ◽  
Xiaodong Du ◽  
...  
Keyword(s):  
Gene Family ◽  
Function Analysis ◽  
Pearl Oyster ◽  
Pinctada Fucata ◽  
Genome Wide ◽  
And Function

scholarly journals Molecular characterization and function analysis of the rice OsDUF617 family

2021 ◽  
Vol 35 (1) ◽  
pp. 862-872
Author(s):  
Chunliu Li ◽  
Dejia Hou ◽  
Lin Zhang ◽  
Xiaohong Li ◽  
Jiangbo Fan ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Function Analysis ◽  
And Function

scholarly journals The Serine Proteinase Inhibitor (Serpin) Plasminogen Activation Inhibitor Type 2 Protects against Viral Cytopathic Effects by Constitutive Interferon α/β Priming

1998 ◽  
Vol 187 (11) ◽  
pp. 1799-1811 ◽  
Author(s):  
Toni M. Antalis ◽  
May La Linn ◽  
Karen Donnan ◽  
Luis Mateo ◽  
Joy Gardner ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Proteinase Inhibitor ◽  
Rapid Development ◽  
Serine Proteinase ◽  
Productive Infection ◽  
Interferon Α ◽  
Serine Proteinase Inhibitor ◽  
Cytopathic Effects ◽  
Inhibitor Type

The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is well characterized as an inhibitor of extracellular urokinase-type plasminogen activator. Here we show that intracellular, but not extracellular, PAI-2 protected cells from the rapid cytopathic effects of alphavirus infection. This protection did not appear to be related to an effect on apoptosis but was associated with a PAI-2–mediated induction of constitutive low-level interferon (IFN)-α/β production and IFN-stimulated gene factor 3 (ISGF3) activation, which primed the cells for rapid induction of antiviral genes. This primed phenotype was associated with a rapid development of resistance to infection by the PAI-2 transfected cells and the establishment of a persistent productive infection. PAI-2 was also induced in macrophages in response to viral RNA suggesting that PAI-2 is a virus response gene. These observations, together with the recently demonstrated PAI-2–mediated inhibition of tumor necrosis factor-α induced apoptosis, (a) illustrate that PAI-2 has an additional and distinct function as an intracellular regulator of signal transduction pathway(s) and (b) demonstrate a novel activity for a eukaryotic serpin.

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