Agumbe, the Cherrapunji of southern India, is a bastion of rich endemic flora. In the present study of random sampling, a total of 570 species of flowering plants were collected belonging to 370 genera and 105 families, including a few endemic and Red Listed medicinal plants such as Garcinia gummi-gutta (L.) Roxb., Dipterocarpus indicus Bedd., Dysoxylum malabaricum Bedd. ex C.DC., Elaeocarpus tuberculatus Roxb., Hopea canarensis Hole, Calophyllum apetalum Willd., Adenia hondala (Gaertn.) W.J.de Wilde, and Myristica dactyloides Gaertn. Family Leguminosae contributes the maximum number of species (47 species) followed by Rubiaceae (32 species) and Asteraceae (27 species) and Genera Ficus (9 species), Diospyros (8 species) and Syzygium (7 species) are the dominant genera. Trees (185 species) are the dominant species followed by herbs (162 species), climbers (117 species), shrubs (62 species), grasses and sedges (19 species), epiphytes (15 species) and parasites (10 species).