The three groups of abnormal chick embryos known as talpids show a common pattern of remarkably widespread pleiotropic abnormalities, thought to represent the homozygous expression of one or other of three autosomal recessive genes, symbolized respectively as ta1, ta2, ta3. Ede & Kelly (1964 a, b) described in detail the abnormalities of the talpid3 embryos (ta3/ta3), which are essentially similar to those in Cole's talpid (ta1/ta1) (Inman, 1946), while homozygotes for talpid2 (Abbott, Taylor & Abplanalp, 1960) survive longer and, unlike the others, have relatively normal heads. All three possess at 11 days the following trunk abnormalities: (1) a shortening of the vertebral column accompanied by much fusion of adjacent vertebrae; (2) failure of cartilage replacement by bone; (3) substantial subcutaneous oedema and failure of the body wall to close ventrally round the viscera; (4) abnormal feather follicle formation; and (5) polydactyly in the shortened limbs. In the head of ta1/ta1 and ta3/ta3 embryos both the eyes and the maxillary processes are drawn together in the midline.