Screening of Mycobacterium tuberculosis genes as putative drug targets for treatment of HIV-TB and lung cancer-TB comorbidities: an in silico analysis

Gene Reports ◽  
2021 ◽  
pp. 101215
Author(s):  
Shobana Sundar ◽  
Lokesh Thangamani ◽  
Shanmughavel Piramanayagam ◽  
Jeyakumar Natarajan
Keyword(s):  
Lung Cancer ◽  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
Drug Targets ◽  
In Silico Analysis ◽  
Silico Analysis

In silico analysis and prioritization of drug targets in Fusarium solani

2015 ◽  
Vol 84 (2) ◽  
pp. 81-84 ◽  
Author(s):  
Muthukumaran Sivashanmugam ◽  
Hemavathy Nagarajan ◽  
Umashankar Vetrivel ◽  
Gayathri Ramasubban ◽  
Kulandai Lily Therese ◽  
...  
Keyword(s):  
Fusarium Solani ◽  
In Silico ◽  
Drug Targets ◽  
In Silico Analysis ◽  
Silico Analysis

In silico analysis of mycobacteriophage Che12 genome: Characterization of genes required to lysogenise Mycobacterium tuberculosis

2007 ◽  
Vol 31 (2) ◽  
pp. 82-91 ◽  
Author(s):  
N.S. Gomathi ◽  
H. Sameer ◽  
Vanaja Kumar ◽  
S. Balaji ◽  
V.N. Azger Dustackeer ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
In Silico Analysis ◽  
Genome Characterization ◽  
Silico Analysis

scholarly journals In Silico Analysis of Some Phytochemicals as Potent Anti-tubercular Agents Targeting Mycobacterium tuberculosis RNA Polymerase and InhA Protein

2020 ◽  
Author(s):  
Md Emran ◽  
Md. Mofijur Rahman ◽  
Afroza Khanam Anika ◽  
Sultana Hossain Nasrin ◽  
Abu Tayab Moin
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Rna Polymerase ◽  
In Silico ◽  
Acyl Carrier Protein ◽  
Low Cost ◽  
In Silico Analysis ◽  
The Past ◽  
Two Agents ◽  
In Silico Biology ◽  
Silico Analysis

Tuberculosis (TB) is a contagious disease, caused by Mycobacterium tuberculosis (MTB) that has infected and killed a lot of people in the past. At present treatments against TB are available at a very low cost. Since these chemical drugs have many adverse effects on health, more attention is now given on the plant-derived phytochemicals as potential agents to fight against TB. In this study, 5 phytochemicals, 4-hydroxybenzaldehyde, benzoic acid, bergapten, psoralen, and p-hydroxybenzoic acid, are selected to test their potentiality, safety, and efficacy against two potential targets, the MTB RNA polymerase and enoyl-acyl carrier protein (ACP) reductase, the InhA protein, using various tools of in silico biology. The molecular docking experiment, drug-likeness property test, ADME/T-test, P450 SOM prediction, pharmacophore mapping, and modeling, solubility testing, DFT calculations, and PASS prediction study had confirmed that all the molecules had the good potentiality to inhibit the two targets. However, two agents, 4-hydroxybenzaldehyde and bergapten were considered as the best agents among the five selected agents and they also showed far better results than the two currently used drugs, that function in these pathways, rifampicin (MTB RNA polymerase) and isoniazid (InhA protein). These two agents can be used effectively to treat tuberculosis.

Strong Anti-tumorous Potential of Nardostachys jatamansi Rhizome Extract on Glioblastoma and In Silico Analysis of its Molecular Drug Targets

2016 ◽  
Vol 17 (1) ◽  
pp. 74-88 ◽  
Author(s):  
Himanshi Kapoor ◽  
Nalini Yadav ◽  
Madhu Chopra ◽  
Sushil Mahapatra ◽  
Veena Agrawal
Keyword(s):  
In Silico ◽  
Drug Targets ◽  
In Silico Analysis ◽  
Nardostachys Jatamansi ◽  
Silico Analysis
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