19: Use of Sildenafil for Prevention of Right Heart Failure in Heart Transplant Recipients with Pulmonary Hypertension

Abstract Background: There is very little literature on Pulmonary hypertension associated with myocardial amyloid degeneration. At present, only 10 cases pulmonary hypertension cased by amyloid protein deposits in the pulmonary blood vessels have been reported by Eder et al. We reported a case that the patient was pulmonary artery hypertension combined with myocardial amyloid change. It’s aim to claims that pulmonary hypertension is most likely caused by amyloid fibrin deposition in pulmonary blood vessels.Case presentation: We report a case of a 65-year-old male patient with with AL and ATTR combined type amyloidosis who developed right heart failure because of severe pulmonary hypertension. Pulmonary hypertension due to deposition of amyloid in the pulmonary vasculature is an uncommon finding; however, it should be considered in cases of unexplained pulmonary hypertension in patients with amyloidosis.Conclusion: we present a men with amyloidosis who developed dyspnea and right heart failure and was diagnosed with pulmonary hypertension, most probably secondary to pulmonary vascular involvement by amyloid fibrils.

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Efficacy and safety of a calcium sensitizer, levosimendan, in patients with right heart failure due to pulmonary hypertension

The Clinical Respiratory Journal ◽

10.1111/crj.12699 ◽

2017 ◽

Vol 12 (4) ◽

pp. 1518-1525 ◽

Cited By ~ 7

Author(s):

Rong Jiang ◽

Qin‐Hua Zhao ◽

Wen‐Hui Wu ◽

Rui Zhang ◽

Ping Yuan ◽

...

Keyword(s):

Heart Failure ◽

Pulmonary Hypertension ◽

Right Heart Failure ◽

Efficacy And Safety ◽

Right Heart ◽

Calcium Sensitizer

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Critical Care Management of Decompensated Right Heart Failure in Pulmonary Arterial Hypertension Patients – An Ongoing Approach

The Journal of Critical Care Medicine ◽

10.2478/jccm-2021-0020 ◽

2021 ◽

Vol 7 (3) ◽

pp. 170-183

Author(s):

Ioan Tilea ◽

Andreea Varga ◽

Anca-Meda Georgescu ◽

Bianca-Liana Grigorescu

Keyword(s):

Heart Failure ◽

Pulmonary Hypertension ◽

Intensive Care ◽

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Care Management ◽

Right Heart Failure ◽

Right Heart ◽

Continuous Increase ◽

Pulmonary Arterial

Abstract Despite substantial advancements in diagnosis and specific medical therapy in pulmonary arterial hypertension patients’ management, this condition continues to represent a major cause of mortality worldwide. In pulmonary arterial hypertension, the continuous increase of pulmonary vascular resistance and rapid development of right heart failure determine a poor prognosis. Against targeted therapy, patients inexorable deteriorate over time. Pulmonary arterial hypertension patients with acute right heart failure who need intensive care unit admission present a complexity of the disease pathophysiology. Intensive care management challenges are multifaceted. Awareness of algorithms of right-sided heart failure monitoring in intensive care units, targeted pulmonary hypertension therapies, and recognition of precipitating factors, hemodynamic instability and progressive multisystem organ failure requires a multidisciplinary pulmonary hypertension team. This paper summarizes the management strategies of acute right-sided heart failure in pulmonary arterial hypertension adult cases based on recently available data.

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