631 Right Ventricle Failure after LVAD Implantation: Short-Term Support Is Sufficient

Diabetes mellitus is associated with a high incidence and poor prognosis of cardiovascular disease. The aim of the present study was to examine the effect of relatively short-term (5 weeks) Type I diabetes on the left ventricle, the right ventricle and the vessel (vein) on the left ventricle of the myocardium at molecular level by FTIR (Fourier-transform infrared) microspectroscopy. The rats were categorized into two groups: control group (for the left ventricle myocardium, n=8; for the right ventricle myocardium, n=9; for the vein, n=9) and streptozotocin-induced diabetic group (for the left ventricle myocardium, n=7; for the right ventricle myocardium, n=9; for the vein, n=8). Two adjacent cross-sections of 9 μm thickness were taken from the ventricles of the hearts in two groups of rats by using a cryotome. The first sections were used for FTIR microspectroscopy measurements. The second serial sections were stained by haematoxylin/eosin for comparative purposes. Diabetes caused an increase in the content of lipids, an alteration in protein profile with a decrease in α-helix and an increase in β-sheet structure as well as an increase in glycogen and glycolipid contents in both ventricles and the vein. Additionally, the collagen content was found to be increased in the vein of the diabetic group. The present study demonstrated that diabetes-induced alterations in the rat heart can be detected by correlating the IR spectral changes with biochemical profiles in detail. The present study for the first time demonstrated the diabetes-induced alterations at molecular level in both ventricle myocardia and the veins in relatively short-term diabetes.

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Levosimendan in the management of right ventricle failure early after lung transplant

British Journal of Anaesthesia ◽

10.1093/bja/el_9111 ◽

2012 ◽

Vol 109 (eLetters) ◽

Author(s):

Paolo Feltracco

Keyword(s):

Right Ventricle ◽

Lung Transplant ◽

Right Ventricle Failure

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Echocardiographic estimation of right ventricular wall tension: haemodynamic comparison and long-term follow-up

Pulmonary Circulation ◽

10.1177/2045894019895420 ◽

2019 ◽

Vol 9 (4) ◽

pp. 204589401989542 ◽

Cited By ~ 1

Author(s):

Umberto Annone ◽

Pier P. Bocchino ◽

Walter G. Marra ◽

Fabrizio D’Ascenzo ◽

Corrado Magnino ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Right Ventricle ◽

Right Ventricular ◽

Tricuspid Regurgitation ◽

Ventricular Wall ◽

Wall Tension ◽

Right Ventricular Wall ◽

Right Ventricle Failure ◽

Peak Gradient

Prognosis in pulmonary hypertension is strictly linked to right ventricle failure, which results from uncoupling between right ventricle function and its afterload. This study sought to describe how to estimate with echocardiography right ventricular wall tension, its correlation with right ventricle haemodynamics and its prognostic role. A total of 190 patients without overt right ventricle failure but with suspected pulmonary hypertension on a previous echocardiogram underwent right heart catheterization and nearly-simultaneous echocardiography. Right ventricular wall tension was estimated according to Laplace’s law as right ventricle length × tricuspid regurgitation peak gradient and it was correlated with right ventricle haemodynamic profile; its potential prognostic impact was tested along with canonical right ventricle function parameters. Right ventricular wall tension correlated significantly with invasive estimation of right ventricle end-diastolic pressure (R: 0.343, p < 0.001) and with several other haemodynamic variables, such as mean pulmonary artery pressure, pulmonary artery compliance, transpulmonary gradient, pulmonary vascular resistance, right atrial pressure and right ventricle stroke work index (all p < 0.001). At a mean follow-up of five years and three months, only right ventricular wall tension was associated to all-cause mortality ( p = 0.036), while tricuspid annular plane systolic excursion ( p = 0.536), right ventricle fractional area change ( p = 0.383), right ventricle fractional area change ( p = 0.076), tricuspid regurgitation peak gradient ( p = 0.107) and tricuspid annular plane systolic excursion/tricuspid regurgitation peak gradient ( p = 0.181) could not. We identified a novel bedside echocardiographic predictor of altered right ventricle haemodynamics, which is precociously altered in patients without overt right ventricle failure and is associated to all-cause mortality at a long-term follow-up. Further studies are needed to confirm its role in pulmonary hypertension patients.

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Circulatory support with right ventricular assist device and intra-aortic balloon counterpulsation in patient with right ventricle failure after pulmonary embolectomy

Interactive Cardiovascular and Thoracic Surgery ◽

10.1510/icvts.2008.175877 ◽

2008 ◽

Vol 7 (4) ◽

pp. 643-645 ◽

Cited By ~ 10

Author(s):

R. Lango ◽

M. M. Kowalik ◽

K. Klajbor ◽

J. Rogowski

Keyword(s):

Right Ventricle ◽

Ventricular Assist Device ◽

Circulatory Support ◽

Assist Device ◽

Ventricular Assist ◽

Pulmonary Embolectomy ◽

Intra Aortic Balloon Counterpulsation ◽

Right Ventricular Assist Device ◽

Balloon Counterpulsation ◽

Right Ventricle Failure

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Short-Term Circulatory and Right Ventricle Support in Cardiogenic Shock

Heart Failure Clinics ◽

10.1016/j.hfc.2018.06.014 ◽

2018 ◽

Vol 14 (4) ◽

pp. 579-583 ◽

Cited By ~ 6

Author(s):

Ibrahim Sultan ◽

Arman Kilic ◽

Ahmet Kilic

Keyword(s):

Right Ventricle ◽

Cardiogenic Shock ◽

Short Term

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Adverse remodeling of the subpulmonary left ventricle in patient with systemic right ventricle is associated with clinical outcome

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeab090.118 ◽

2021 ◽

Vol 22 (Supplement_2) ◽

Author(s):

B Santens ◽

F Helsen ◽

A Van De Bruaene ◽

P De Meester ◽

A Budts ◽

...

Keyword(s):

Heart Failure ◽

Left Ventricle ◽

Clinical Outcome ◽

Right Ventricle ◽

Prognostic Markers ◽

Volume Index ◽

Short Term ◽

Systemic Right Ventricle ◽

Adverse Remodeling

Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): This research received project funding by KU Leuven Background – Early recognition of adverse remodeling is important since outcome is unfavorable once patients with a systemic right ventricle (sRV) become symptomatic. We aimed assessing prognostic markers linked to short-term clinical evolution in this population. Purpose - We aimed assessing short-term clinical evolution and early prognostic markers of cardiac complications in adults with sRV (atrial switch repair for D-transposition of the great arteries (D-TGA) and congenitally corrected transposition of the great arteries (ccTGA)) based on detailed phenotyping. Methods– Thirty-three patients with sRV underwent detailed phenotyping including exercise CMR. Adverse outcome was a composite of heart failure episode and tachyarrhythmia. Descriptive statistics and univariate cox regression analyses were performed. Results - Thirty-three patients (76% male) with sRV were followed over mean follow-up time of 3 years. Mean age was 40 ± 8 (range 26-57) years at latest follow-up. When compared to baseline, (I) most patients remained in NYHA functional class I (76%), (II) the degree of severity of the SAVV regurgitation rose and (III) more electrical instability was documented at latest follow-up. Six (18%) of a total of nine events were counted as first cardiovascular events (9% heart failure, 9% arrhythmia). NTproBNP (HR 11.02 (95%CI 1.296-93.662), p= 0.028), oxygen pulse (HR 1.202 (95% CI 1.012-1.428), p = 0.037), left ventricle end diastolic volume index (LVEDVi) in rest (HR 1.046 (95% CI 1.002-1.092), p = 0.041) and during exercise (HR 1.035 (95% CI 1.002-1.069), p = 0.038), stroke volume index (SVi) of the subpulmonary left ventricle (LV) in rest (HR 1.154 (95% CI 1.005-1.322), p = 0.038) and at peak exercise (HR 1.065 (95% CI 1.007-1.125), p = 0.026) were significantly associated with the first cardiovascular event (Figure 1A and B). Conclusion – NTproBNP was by far the best prognostic marker for clinical outcome. Adverse remodelling with increase of LVEDVi and SVi of the subpulmonary LV at rest and during exercise were associated with worse clinical outcome. We theorize that remodeling of the subpulmonary ventricle might be an early sign of a failing sRV circulation (Figure 2).

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