Peripheral Blood Gene Expression Identifies Damage-Associated Innate Immune Pathways in Patients With Primary Graft Dysfunction After Lung Transplantation

2015 ◽  
Vol 34 (4) ◽  
pp. S135-S136
Author(s):  
E. Cantu ◽  
J.M. Diamond ◽  
Y. Suzuki ◽  
J. Tiwari ◽  
B. Beduhn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Transplantation ◽  
Peripheral Blood ◽  
Innate Immune ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Blood Gene Expression ◽  
Peripheral Blood Gene Expression ◽  
Immune Pathways

scholarly journals Systems-level analysis of peripheral blood gene expression in dementia patients reveals an innate immune response shared across multiple disorders

2019 ◽  
Author(s):  
D Nachun ◽  
EM Ramos ◽  
A Karydas ◽  
D Dokuru ◽  
F Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Inflammatory Response ◽  
Peripheral Blood ◽  
Transcriptional Response ◽  
Innate Immune ◽  
Blood Gene Expression ◽  
Dementia Patients ◽  
Peripheral Blood Gene Expression ◽  
Level Analysis

AbstractThe role of peripheral inflammation in dementia is an important but complex topic. We present here the largest cohort of peripheral blood gene expression data ever assembled from patients with dementia and matching controls. Importantly, this cohort includes individuals from a diverse set of dementia disorders, including Alzheimer’s Disease (AD), mild cognitive impairment (MCI), and multiple disorders within the frontotemporal dementia (FTD) spectrum. We found strong transcriptional evidence of an innate immune inflammatory response, mediated by monocytes and neutrophils, in AD, MCI, and two FTD subtypes, PSP and nfvPPA. This transcriptional inflammatory response is enriched for genetic risk for AD, in part because it is also enriched for microglial genes, which have previously been implicated in AD risk. Finally, we show that this transcriptional response is strongly enriched for binding of the transcription factors PU.1 and RELA, which have previously been linked to AD risk and progression.

scholarly journals Peripheral blood gene expression profiling in rheumatoid arthritis

2005 ◽  
Vol 6 (5) ◽  
pp. 388-397 ◽  
Author(s):  
F M Batliwalla ◽  
E C Baechler ◽  
X Xiao ◽  
W Li ◽  
S Balasubramanian ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Expression ◽  
Gene Expression Profiling ◽  
Peripheral Blood ◽  
Expression Profiling ◽  
Blood Gene Expression ◽  
Peripheral Blood Gene Expression
Sign in / Sign up

Export Citation Format

Share Document