scholarly journals The role of bone morphogenetic protein 4 in inner ear development and function

2007 ◽  
Vol 225 (1-2) ◽  
pp. 71-79 ◽  
Author(s):  
Marsha N. Blauwkamp ◽  
Lisa A. Beyer ◽  
Lisa Kabara ◽  
Keiji Takemura ◽  
Timothy Buck ◽  
...  
Keyword(s):  
Inner Ear ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 4 ◽  
Ear Development ◽  
Morphogenetic Protein ◽  
Inner Ear Development ◽  
And Function

scholarly journals Retinoic Acid Repression of Bone Morphogenetic Protein 4 in Inner Ear Development

2003 ◽  
Vol 23 (7) ◽  
pp. 2277-2286 ◽  
Author(s):  
Deborah L. Thompson ◽  
Lisa M. Gerlach-Bank ◽  
Kate F. Barald ◽  
Ronald J. Koenig
Keyword(s):  
Retinoic Acid ◽  
Inner Ear ◽  
Cell Line ◽  
Bone Morphogenetic Protein ◽  
Semicircular Canal ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein ◽  
Inner Ear Development ◽  
Acid Effect

ABSTRACT Bone morphogenetic protein 4 (BMP4) and retinoic acid are important for normal development of the inner ear, but whether they are linked mechanistically is not known. BMP4 antagonists disrupt semicircular canal formation, as does exposure to retinoic acid. We demonstrate that retinoic acid directly down-regulates BMP4 transcription in a mouse inner ear-derived cell line, and we identify a novel promoter in the second intron of the BMP4 gene that is a target of this regulation both in the cell line and in the mouse embryonic inner ear in vivo. The importance of this down-regulation is demonstrated in chicken embryos by showing that the retinoic acid effect on semicircular canal development can be overcome by exogenous BMP4.

scholarly journals Role of microRNAs in inner ear development and hearing loss

Gene ◽  
2019 ◽  
Vol 686 ◽  
pp. 49-55 ◽  
Author(s):  
Rahul Mittal ◽  
George Liu ◽  
Sai P. Polineni ◽  
Nicole Bencie ◽  
Denise Yan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals The role of Pax2 in mouse inner ear development

2004 ◽  
Vol 272 (1) ◽  
pp. 161-175 ◽  
Author(s):  
Quianna Burton ◽  
Laura K Cole ◽  
Michael Mulheisen ◽  
Weise Chang ◽  
Doris K Wu
Keyword(s):  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development

The role of bone morphogenetic protein 4 in corneal injury repair

2021 ◽  
pp. 108769
Author(s):  
Huicong Hu ◽  
Shurong Wang ◽  
Yuxi He ◽  
Sitong Shen ◽  
Boyuan Yao ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 4 ◽  
Corneal Injury ◽  
Injury Repair ◽  
Morphogenetic Protein

scholarly journals Human myxomatous mitral valve prolapse: Role of bone morphogenetic protein 4 in valvular interstitial cell activation

2012 ◽  
Vol 227 (6) ◽  
pp. 2595-2604 ◽  
Author(s):  
Rachana Sainger ◽  
Juan B. Grau ◽  
Emanuela Branchetti ◽  
Paolo Poggio ◽  
William F. Seefried ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Bone Morphogenetic Protein ◽  
Mitral Valve Prolapse ◽  
Cell Activation ◽  
Interstitial Cell ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

scholarly journals Filling the Silent Void: Genetic Therapies for Hearing Impairment

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Joel Sng ◽  
Thomas Lufkin
Keyword(s):  
Inner Ear ◽  
Hearing Impairment ◽  
Hair Cells ◽  
Genetic Disorders ◽  
Environmental Damage ◽  
Inner Ear Development ◽  
Sensory Hair Cells ◽  
And Function ◽  
Function Potential

The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail.

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