scholarly journals Adjustment of lifetime risks of space radiation-induced cancer by the healthy worker effect and cancer misclassification

Heliyon ◽  
2015 ◽  
Vol 1 (4) ◽  
pp. e00048 ◽  
Author(s):  
Leif E. Peterson ◽  
Tatiana Kovyrshina
Keyword(s):  
Space Radiation ◽  
Healthy Worker Effect ◽  
Radiation Induced Cancer ◽  
Radiation Induced

scholarly journals Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System

2021 ◽  
Vol 22 (14) ◽  
pp. 7713
Author(s):  
Alyssa Tidmore ◽  
Sucharita M. Dutta ◽  
Arriyam S. Fesshaye ◽  
William K. Russell ◽  
Vania D. Duncan ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Performance ◽  
Space Radiation ◽  
Label Free ◽  
Proteomic Profiling ◽  
Neurocognitive Deficits ◽  
Male Wistar Rats ◽  
Radiation Induced ◽  
Induced Changes

Exposure of rodents to <20 cGy Space Radiation (SR) impairs performance in several hippocampus-dependent cognitive tasks, including spatial memory. However, there is considerable inter-individual susceptibility to develop SR-induced spatial memory impairment. In this study, a robust label-free mass spectrometry (MS)-based unbiased proteomic profiling approach was used to characterize the composition of the hippocampal proteome in adult male Wistar rats exposed to 15 cGy of 1 GeV/n 48Ti and their sham counterparts. Unique protein signatures were identified in the hippocampal proteome of: (1) sham rats, (2) Ti-exposed rats, (3) Ti-exposed rats that had sham-like spatial memory performance, and (4) Ti-exposed rats that impaired spatial memory performance. Approximately 14% (159) of the proteins detected in hippocampal proteome of sham rats were not detected in the Ti-exposed rats. We explored the possibility that the loss of the Sham-only proteins may arise as a result of SR-induced changes in protein homeostasis. SR-exposure was associated with a switch towards increased pro-ubiquitination proteins from that seen in Sham. These data suggest that the role of the ubiquitin-proteome system as a determinant of SR-induced neurocognitive deficits needs to be more thoroughly investigated.

Effects of Dietary Supplements on Space Radiation-Induced Oxidative Stress in Sprague-Dawley Rats

2004 ◽  
Vol 162 (5) ◽  
pp. 572-579 ◽  
Author(s):  
Jun Guan ◽  
X. Steven Wan ◽  
Zhaozong Zhou ◽  
Jeffrey Ware ◽  
Jeremiah J. Donahue ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dietary Supplements ◽  
Space Radiation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Radiation Induced

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice

DNA Repair ◽  
2002 ◽  
Vol 1 (2) ◽  
pp. 143-157 ◽  
Author(s):  
Gijsbertus T.J van der Horst ◽  
Lisiane Meira ◽  
Theo G.M.F Gorgels ◽  
Jan de Wit ◽  
Susana Velasco-Miguel ◽  
...  
Keyword(s):  
Cockayne Syndrome ◽  
Cancer Predisposition ◽  
Mutant Mice ◽  
Uvb Radiation ◽  
Radiation Induced Cancer ◽  
Group A ◽  
Radiation Induced

scholarly journals 293 Risk assessment for radiation-induced cancer after Interventional Cardiology procedures

2010 ◽  
Vol 2 (1) ◽  
pp. 95
Author(s):  
Sophie Jacob ◽  
Olivier Catelinois ◽  
Olivier Bar ◽  
Carlo Maccia ◽  
Dominique Laurier ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Interventional Cardiology ◽  
Radiation Induced Cancer ◽  
Radiation Induced

Cancer Mortality Following Cardiac Catheterization: A Preliminary Follow-up Study on 4,891 Irradiated Children

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 235-239
Author(s):  
Robert F. Spengler ◽  
David H. Cook ◽  
E. Aileen Clarke ◽  
Peter M. Olley ◽  
Alice M. Newman
Keyword(s):  
Cardiac Catheterization ◽  
Cancer Mortality ◽  
Wilms Tumor ◽  
Cancer Death ◽  
Radiation Induced Cancer ◽  
Radiation Induced ◽  
System Tumor ◽  
Sick Children ◽  
Cardiac Catheterizations

A retrospective cohort study was conducted on the risk of radiation-induced cancer mortality following cardiac catheterization. The study included 4,891 children with congenital heart disease who were assessed by cardiac catheterization during 1946 to 1968 at The Hospital for Sick Children, Toronto. The cohort was matched against the Ontario cancer death file from 1950 to 1975. The average period of follow-up was 13 years and more than 66,000 person-years have been accrued from the cohort. No deaths from breast cancer or thyroid cancer were identified. Five cancer deaths were observed and compared with 4.8 expected deaths based on Ontario cancer death rates. The five cancer deaths resulted from three leukemias, one Wilms' tumor, and one unspecified nervous system tumor. The preliminary findings did not demonstrate a significant leukemia risk arising from diagnostic cardiac catheterizations. Continued follow-up of this cohort is required to evaluate the risk of breast and thyroid cancers which can occur more than 20 years following radiation exposure.

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