scholarly journals Spontaneous functional full recovery from motor and sensory deficits in adult mice after mild spinal cord injury

Heliyon ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. e01847 ◽  
Author(s):  
Yohei Kakuta ◽  
Anna Adachi ◽  
Marino Yokohama ◽  
Toshiki Horii ◽  
Tokue Mieda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Full Recovery ◽  
Sensory Deficits ◽  
Adult Mice ◽  
Cord Injury

scholarly journals Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury

Spinal Cord ◽  
2010 ◽  
Vol 49 (1) ◽  
pp. 70-75 ◽  
Author(s):  
H Lundell ◽  
D Barthelemy ◽  
A Skimminge ◽  
T B Dyrby ◽  
F Biering-Sørensen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Cord Atrophy ◽  
Sensory Deficits ◽  
Cord Injury

Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice

2005 ◽  
Vol 27 (8) ◽  
pp. 812-819 ◽  
Author(s):  
Hajime Kimura ◽  
Masahide Yoshikawa ◽  
Ryousuke Matsuda ◽  
Hayato Toriumi ◽  
Fumihiko Nishimura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Adult Mice ◽  
Cord Injury

scholarly journals ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice

2009 ◽  
Vol 512 (2) ◽  
pp. 243-255 ◽  
Author(s):  
Edward T. Mahoney ◽  
Richard L. Benton ◽  
Melissa A. Maddie ◽  
Scott R. Whittemore ◽  
Theo Hagg
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Endothelial Cells ◽  
Adult Mice ◽  
Cord Injury

scholarly journals Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Munehisa Shinozaki ◽  
Yuichiro Takahashi ◽  
Masahiko Mukaino ◽  
Nobuhito Saito ◽  
Yoshiaki Toyama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Open Field ◽  
Injury Severity ◽  
Basic Research ◽  
Maximum Speed ◽  
Adult Mice ◽  
Cord Injury ◽  
Novel Method ◽  
Novel Concept

In basic research on spinal cord injury (SCI), behavioral evaluation of the SCI animal model is critical. However, it is difficult to accurately evaluate function in the mouse SCI model due to the small size of mice. Although the open-field scoring scale is an outstanding appraisal method, supplementary objective tests are required. Using a compact SCANET system, in which a mouse carries out free movement for 5 min, we developed a novel method to detect locomotor ability. A SCANET system samples the horizontal coordinates of a mouse every 0.1 s, and both the speed and acceleration of its motion are calculated at each moment. It was found that the maximum speed and acceleration of motion over 5 min varied by injury severity. Moreover, these values were significantly correlated with open-field scores. The maximum speed and acceleration of SCI model mice using a SCANET system are objective, easy to obtain, and reproducible for evaluating locomotive function.

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