CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury

The majority of the people with incomplete spinal cord injury lose their walking ability, due to the weakness of their muscle motors in providing torque. As a result, developing assistive devices to improve their conditionis of great importance. In this study, a combined application of the saddle-assistive device (S-AD) and mechanical medial linkage or thosis was evaluated to improve the walking ability in patients with spinal cord injury in the gait laboratory. This mobile assistive device is called the saddle-assistive device equipped with medial linkage or thosis (S-ADEM). In this device, a mechanical orthosis was used in a wheeled walker as previously done in the literature. Initially, for evaluation of the proposed assistive device, the experimental results related to the forces and torques exerted on the feet and upper limbs of a person with the incomplete Spinal Cord Injury (SCI) during walking usingthe standard walker were compared with an those obtained from using the S-ADEM on an able-bodied subject. It was found that using this combination of assistive devices decreases the vertical force and torque on the foot at the time of walking by 53% and 48%, respectively compared to a standard walker. Moreover, the hand-reaction force on the upper limb was negligible instanding and walking positions usingthe introduced device. The findings of this study revealed that the walking ability of the patients with incomplete SCI was improved using the proposed device, which is due to the bodyweight support and the motion technology used in it.

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Effect of pelvic laparoscopic implantation of neuroprosthesis in spinal cord injured subjects: a 1-year prospective randomized controlled study

Spinal Cord ◽

10.1038/s41393-021-00693-7 ◽

2021 ◽

Author(s):

Helge Kasch ◽

Uffe Schou Løve ◽

Anette Bach Jønsson ◽

Kaare Eg Severinsen ◽

Marc Possover ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Outcome Measures ◽

Outcome Measure ◽

Secondary Outcome ◽

Controlled Study ◽

Control Group ◽

Walking Ability ◽

Data Set ◽

Cord Injury

Abstract Study design 1-year prospective RCT. Objective Examine the effect of implantable pulse generator and low-frequency stimulation of the pelvic nerves using laparoscopic implantation of neuroprosthesis (LION) compared with neuromuscular electrical stimulation (NMES) in SCI. Methods Inclusion criteria: traumatic spinal cord injury (SCI), age 18–55 years, neurological level-of-injury Th4–L1, time-since-injury >1 year, and AIS-grades A–B. Participants were randomized to (A) LION procedure or (B) control group receiving NMES. Primary outcome measure: Walking Index for Spinal Cord Injury (WISCI-II), which is a SCI specific outcome measure assessing ability to ambulate. Secondary outcome measures: Spinal Cord Independence Measure III (SCIM III), Patient Global Impression of Change (PGIC), Penn Spasm Frequency Scale (PSFS), severity of spasticity measured by Numeric Rating Scale (NRS-11); International Spinal Cord Injury data sets-Quality of Life Basic Data Set (QoLBDS), and Brief Pain Inventory (BPI). Results Seventeen SCI individuals, AIS grade A, neurological level ranging from Th4–L1, were randomized to the study. One individual was excluded prior to intervention. Eight participants (7 males) with a mean age (SD) of 35.5 (12.4) years were allocated to the LION procedure, 8 participants (7 males) with age of 38.8 (15.1) years were allocated to NMES. Significantly, 5 LION group participants gained 1 point on the WISCI II scale, (p < 0.013; Fisher´s exact test). WISCI II scale score did not change in controls. No significant changes were observed in the secondary outcome measures. Conclusion The LION procedure is a promising new treatment for individuals with SCI with significant one-year improvement in walking ability.

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Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113197 ◽

2021 ◽

Vol 405 ◽

pp. 113197

Author(s):

Lu Pan ◽

Botao Tan ◽

Weiwei Tang ◽

Meiling Luo ◽

Yuan Liu ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Upper Extremity ◽

Motor Function ◽

Axon Regeneration ◽

Cervical Spinal Cord ◽

Adult Mice ◽

Function Recovery ◽

Cord Injury ◽

Pten Inhibition

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Midsagittal tissue bridges are associated with walking ability in incomplete spinal cord injury: A magnetic resonance imaging case series

Journal of Spinal Cord Medicine ◽

10.1080/10790268.2018.1527079 ◽

2018 ◽

Vol 43 (2) ◽

pp. 268-271 ◽

Cited By ~ 6

Author(s):

Denise R. O’Dell ◽

Kenneth A. Weber ◽

Jeffrey C. Berliner ◽

James M. Elliott ◽

Jordan R. Connor ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Magnetic Resonance ◽

Case Series ◽

Walking Ability ◽

Incomplete Spinal Cord Injury ◽

Resonance Imaging ◽

Cord Injury

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Spontaneous functional full recovery from motor and sensory deficits in adult mice after mild spinal cord injury

Heliyon ◽

10.1016/j.heliyon.2019.e01847 ◽

2019 ◽

Vol 5 (6) ◽

pp. e01847 ◽

Cited By ~ 2

Author(s):

Yohei Kakuta ◽

Anna Adachi ◽

Marino Yokohama ◽

Toshiki Horii ◽

Tokue Mieda ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Full Recovery ◽

Sensory Deficits ◽

Adult Mice ◽

Cord Injury

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EFFECT OF LOWER EXTREMITY EXOSKELETON ROBOT IMPROVING WALKING FUNCTION AND ACTIVITY IN PATIENTS WITH COMPLETE SPINAL CORD INJURY

Journal of Mechanics in Medicine and Biology ◽

10.1142/s0219519419400608 ◽

2019 ◽

Vol 19 (08) ◽

pp. 1940060

Author(s):

XINGANG BAI ◽

XIANG GOU ◽

WENCHUN WANG ◽

CHAO DONG ◽

FANGXU QUE ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Adverse Events ◽

Lower Extremity ◽

Controlled Trial ◽

Walking Ability ◽

Walk Test ◽

Exoskeleton Robot ◽

Cord Injury ◽

Complete Spinal Cord Injury

The objective of this research was to evaluate the effectiveness and safety of Lower Extremity Exoskeleton Robot improving walking function and activity in patients with complete spinal cord injury. A prospective, open and self-controlled trial was conducted which include eight patients with complete spinal cord injury accepted Lower Extremity Exoskeleton Robot training with Aider 1.0 and Aider 1.1 for 2 weeks. The 6[Formula: see text]min Walk Test (6MWT), 10[Formula: see text]m Walk Test (10 MWT), Hoffer walking ability rating, Lower Extremity Motor Score (LEMS), Spinal Cord Independence Motor (SCIM), Walking Index for Spinal Cord Injury Version II (WISCI II) were recorded before, 1 week and 2 weeks after training. During the training, the incidence of adverse events (AE), the incidence of serious adverse events (SAE), the incidence of device defects and other safety indicators were observed. Compared with the pre-training, indicators (6MWT, 10MWT, Hoffer walking ability rating, WISCI II) were significantly different after 1 week of training and after 2 weeks of training. Four adverse events occurred during the training period and the incidence of adverse events was 50%. And there was no SAE or device defects. Therefore, it is safe and effective to use the lower extremity exoskeleton robot to complete the walking ability of patients with complete spinal cord injury.

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Robotic-Assisted, Body-Weight–Supported Treadmill Training in Individuals Following Motor Incomplete Spinal Cord Injury

Physical Therapy ◽

10.1093/ptj/85.1.52 ◽

2005 ◽

Vol 85 (1) ◽

pp. 52-66 ◽

Cited By ~ 165

Author(s):

T George Hornby ◽

David H Zemon ◽

Donielle Campbell

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Body Weight ◽

Physical Therapists ◽

Treadmill Training ◽

Neurological Injury ◽

Walking Ability ◽

Incomplete Spinal Cord Injury ◽

Robotic Assisted ◽

Cord Injury

AbstractBackground and Purpose. Performance of therapist-assisted, body-weight–supported treadmill training (BWSTT) to enhance walking ability of people with neurological injury is an area of intense research. Its application in the clinical setting, however, is limited by the personnel and labor requirements placed on physical therapists. Recent development of motorized (“robotic”) rehabilitative devices that provide assistance during stepping may improve delivery of BWSTT. Case Description. This case report describes the use of a robotic device to enhance motor recovery and ambulation in 3 people following motor incomplete spinal cord injury. Interventions. Changes in motor impairment, functional limitations, and locomotor disability were monitored weekly during robotic-assisted BWSTT and following transition to therapist-assisted BWSTT with the assistance of one therapist. Outcomes. Following this training, 2 patients recovered independent over-ground walking and another improved his gait speed and endurance. Discussion. The use of robotic devices may assist physical therapists by providing task-specific practice of stepping in people following neurological injury.

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Development of an unsupervised machine learning algorithm for the prognostication of walking ability in spinal cord injury patients

The Spine Journal ◽

10.1016/j.spinee.2019.09.007 ◽

2020 ◽

Vol 20 (2) ◽

pp. 213-224 ◽

Cited By ~ 11

Author(s):

Zachary DeVries ◽

Mohamad Hoda ◽

Carly S Rivers ◽

Audrey Maher ◽

Eugene Wai ◽

...

Keyword(s):

Machine Learning ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Learning Algorithm ◽

Walking Ability ◽

Machine Learning Algorithm ◽

Unsupervised Machine Learning ◽

Cord Injury

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A Review on Locomotor Training after Spinal Cord Injury: Reorganization of Spinal Neuronal Circuits and Recovery of Motor Function

Neural Plasticity ◽

10.1155/2016/1216258 ◽

2016 ◽

Vol 2016 ◽

pp. 1-20 ◽

Cited By ~ 15

Author(s):

Andrew C. Smith ◽

Maria Knikou

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Motor Function ◽

Walking Ability ◽

Sensorimotor Function ◽

Locomotor Training ◽

Neuronal Circuits ◽

Functional Reorganization ◽

Cord Injury ◽

Neuronal Reorganization

Locomotor training is a classic rehabilitation approach utilized with the aim of improving sensorimotor function and walking ability in people with spinal cord injury (SCI). Recent studies have provided strong evidence that locomotor training of persons with clinically complete, motor complete, or motor incomplete SCI induces functional reorganization of spinal neuronal networks at multisegmental levels at rest and during assisted stepping. This neuronal reorganization coincides with improvements in motor function and decreased muscle cocontractions. In this review, we will discuss the manner in which spinal neuronal circuits are impaired and the evidence surrounding plasticity of neuronal activity after locomotor training in people with SCI. We conclude that we need to better understand the physiological changes underlying locomotor training, use physiological signals to probe recovery over the course of training, and utilize established and contemporary interventions simultaneously in larger scale research studies. Furthermore, the focus of our research questions needs to change from feasibility and efficacy to the following: what are the physiological mechanisms that make it work and for whom? The aforementioned will enable the scientific and clinical community to develop more effective rehabilitation protocols maximizing sensorimotor function recovery in people with SCI.

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