scholarly journals A prospective single blind randomized control trial to compare the outcome after liver resection with or without intermittent portal inflow control (Pringle's maneuver)

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e241
Author(s):  
V. Ramasamy ◽  
B. Sathyamoorthy ◽  
R. Vellaisamy ◽  
A. Anbalagan ◽  
B. Duraisamy ◽  
...  
Keyword(s):  
Liver Resection ◽  
Randomized Control Trial ◽  
Randomized Control ◽  
Pringle’S Maneuver ◽  
Single Blind

scholarly journals Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial

Respiration ◽  
2021 ◽  
pp. 1-11
Author(s):  
Xiao Tang ◽  
Ying-Mei Feng ◽  
Ji-Xiang Ni ◽  
Jia-Ying Zhang ◽  
Li-Min Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Randomized Control Trial ◽  
Corticosteroid Treatment ◽  
Clinical Deterioration ◽  
Control Group ◽  
Number Of Patients ◽  
Early Use ◽  
Randomized Control ◽  
And Control ◽  
Single Blind

<b><i>Background:</i></b> There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia. <b><i>Objective:</i></b> To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia. <b><i>Methods:</i></b> This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization. <b><i>Results:</i></b> We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, <i>p</i> = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6–16 days), which was significantly longer than that in the control group (8 days [2–12 days], <i>p</i> = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (<i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> From this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia. <b><i>Trial Registration:</i></b> ClinicalTrials.gov, NCT04273321.

scholarly journals POTENSI TEH JANTUNG PISANG BATU (Musa balbisiana Colla) SEBAGAI GALAKTAGOG DALAM MENINGKATKAN KADAR PROLAKTIN SERUM SELAMA MASA LAKTASI

Jurnal JKFT ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 54
Author(s):  
Giyawati Yulilania Okinarum ◽  
Lestariningsih Lestariningsih ◽  
Afroh Fauziah
Keyword(s):  
Camellia Sinensis ◽  
Randomized Control Trial ◽  
Control Group ◽  
Musa Balbisiana ◽  
Randomized Control ◽  
Single Blind

Kadar prolaktin yang kurang pada ibu menyusui dapat menghambat proses laktogenesis, akibatnya produksi ASI menurun hingga menjadi salah satu penyebab kegagalan pemberian ASI eksklusif. Jantung pisang batu (Musa balbisiana Colla) menjadi salah satu tanaman yang dapat meningkatkan kadar prolaktin karena adanya efek galaktagog serta kandungan flavonoid dan polifenol yang mampu memengaruhi sistem endokrin dan fungsi hormon untuk merangsang sekresi air susu. Pengembangan jantung pisang batu dalam sediaan teh yang praktis dikonsumsi dan terstandar dapat menjadi salah satu olahan alternatif guna meningkatkan kadar prolaktin serum. Tujuan penelitian ini untuk mengetahui potensi teh jantung pisang batu dalam meningkatkan kadar prolaktin serum. Sebanyak 60 responden dalam penelitian ini adalah ibu menyusui kurang dari 6 bulan di Wilayah Kabupaten Sleman dan Kota Yogyakarta. Sampel diamil secara acak dengan blok permutasi. Desain yang digunakan yaitu single blind randomized control trial pretest posttest control group. Kelompok intervensi mendapatkan teh jantung pisang batu sebanyak dua kantong teh per hari (@2,5 gram) yang harus dikonsumsi selama tujuh hari, sementara itu kelompok intervensi diberikan teh (Camellia sinensis). Kadar prolaktin serum diukur sebelum konsumsi di hari pertama dan setelah konsumsi di hari ke delapan menggunakan analisis biokimia darah VIDAS. Data dianalisis menggunakan uji Wilcoxon dan Uji Mann Whitney, karena data tidak berdistribusi normal. Terdapat perbedaan kadar prolaktin serum yang signifikan anatara kelompok intervensi dan kontrol (p<0,05). Ibu menyusui yang mengkonsumsi teh jantung pisang batu selama tujuh hari berturut-turut mengalami kenaikan kadar prolaktin serum sebesar 30,85%. Teh jantung pisang batu memiliki efek galaktagog yang dapat meningkatkan kadar prolaktin serum selama masa laktasi.

scholarly journals Pemberian Minuman dan Cookies Galohgor Terhadap Kadar Blood Urea Nitrogen (Bun) dan Kreatinin Plasma Penderita Diabetes Melitus Tipe 2

2020 ◽  
Vol 12 (1) ◽  
pp. 1-10
Author(s):  
Laeli Nur hasanah ◽  
Katrin Roosita ◽  
Rimbawan
Keyword(s):  
Blood Urea Nitrogen ◽  
Randomized Control Trial ◽  
Control Group ◽  
Post Intervention ◽  
Urea Nitrogen ◽  
Randomized Control ◽  
Single Blind ◽  
Type 2 Diabetic ◽  
Different Levels

The aim of this research was to analyze the effect of drinks and cookies contained Galohgor extract on Blood Urea Nitrogen (BUN) and creatinine plasma in type 2 diabetic subjects. This study used single blind Randomized Control Trial (RCT) with cross-over design applied on 11 type 2 diabetic subjects in Cikarawang, Babakan and Balumbang Jaya Village-Dramaga, Bogor District, West Java. Each subject received powdered drinks and cookies contained Galohgor extract 2 grams/day (1 gram of Galohgor extract in the form of drink 8 grams and 1 gram of Galohgor extract in the form of cookies 24 grams) and without Galohgor extract (control) for 38 days treatment with four wash-out period between treatment periods. BUN and creatinine levels were conducted by plasma blood sample at pre and post intervention. The result showed that the different levels of BUN between post and pre intervention for Galohgor group compared to control group were -4,9±11,2 mg/dL and -9,6±12,5 mg/dL (p>0,05). The different levels of creatinine between post and pre intervention for Galohgor group compared to control group were -0,1±0,2 mg/dL and -0,1±0,2 mg/dL (p>0,05). Therefore, drinks and cookies contained Galohgor extract 2 gram/day does not affect the BUN and creatinine level of type 2 diabetic subjects. Abstrak : Penelitian ini bertujuan untuk menganalisis pengaruh minuman dan cookies Galohgor terhadap kadar Blood Urea Nitrogen (BUN) dan kadar kreatinin plasma penderita DM tipe 2. Jenis penelitian ini adalah single blind Randomized Control Trial (RCT) dengan desain cross-over pada 11 subjek DM tipe 2 yang dilakukan di desa Cikarawang, Babakan dan Balumbang Jaya, Kecamatan Dramaga, Kabupaten Bogor, Jawa Barat. Masing-masing subjek mendapatkan  minuman dan cookies yang mengandung ekstrak Galohgor  sebesar 2 gram/hari (1 gram ekstrak Galohgor dalam bentuk 8 gram minuman serbuk dan 1 gram ekstrak Galohgor dalam bentuk 24 gram cookies) dan minuman serbuk dan cookies tanpa ekstrak Galohgor (kontrol) selama 38 hari dengan empat bulan periode wash-out antar perlakuan. Kadar BUN dan kreatinin dikumpulkan dari sampel plasma darah pada sebelum dan setelah intervensi. Hasil penelitian menunjukkan rata-rata selisih kadar BUN pada kelompok Galohgor dibandingkan dengan kelompok kontrol yaitu -4,9±11,2 mg/dL dan -9,6±12,5 mg/dL (p>0,05). Kadar kreatinin pada kelompok Galohgor dibandingkan dengan kelompok Galohgor yaitu -0,1±0,2 mg/dL dan -0,1±0,2 mg/dL (p>0,05). Oleh karena itu, pemberian minuman dan cookies yang mengandung ekstrak Galohgor 2 gram/hari tidak berpengaruh terhadap kadar ureum dan kreatinin penderita DM tipe 2.

scholarly journals Comparative Analysis of Two Flap Designs for the Extraction of Impacted Mandibular Horizontal Third Molars: a Multicenter Randomized Control Trial

2021 ◽  
Author(s):  
Tomofumi Naruse ◽  
Satoshi Rokutanda ◽  
Satoshi Inokuchi ◽  
Keisuke Omori ◽  
Souichi Yanamoto ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Postoperative Complications ◽  
Randomized Control Trial ◽  
Operation Time ◽  
Third Molars ◽  
Nerve Paralysis ◽  
Flap Design ◽  
Randomized Control ◽  
Patients Experience ◽  
Single Blind

Abstract Most patients experience postoperative complications caused by the extraction of impacted mandibular horizontal third molars. The aim of the present study was to compare the effects of two flap designs as a refinement on the reduction of postoperative complications. One hundred eighty-eight patients with impacted mandibular horizontal third molars were included in this single-blind, multicenter, randomized control trial. The allocation was determined using a modified envelope flap (mEF) and triangular flap (TF) at 1:1 by the data manager. Postoperative complications (pain, hemorrhage, nerve paralysis, dry socket, and infection) and operation time were assessed 7 ± 1 days after surgery. In all cases, postoperative pain was significantly lower in the mEF group (P<0.05). In the subgroup analysis, postoperative pain was significantly lower in patients with low difficulty (IA, IIA, IIA, IB), which were classified by G.B. Winter classification (P<0.05). Other factors were not significantly associated with the flap design. Our study suggests that mEF resulted in less postoperative pain with a low difficulty of impacted mandibular horizontal third molars. However, the evidence at present is not sufficient to suggest the use of either flap design.

Distance education and diabetes empowerment: A single-blind randomized control trial

2017 ◽  
Vol 11 ◽  
pp. S247-S251 ◽  
Author(s):  
Vahid Zamanzadeh ◽  
Mohammad Zirak ◽  
Masomeh Hemmati Maslakpak ◽  
Naser Parizad
Keyword(s):  
Distance Education ◽  
Randomized Control Trial ◽  
Randomized Control ◽  
Diabetes Empowerment ◽  
Single Blind
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