Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent
behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often
non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning
(F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic
and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques
represent therefore promising approaches for the future management of PanNETs. We conducted a
systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies
were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis,
the prognosis and the detection of therapeutic targets. However, further studies are required. It
is also warranted to standardize the analysis methods and the collection techniques, in order
to validate proteins with a relevance in the personalized approach to PanNETs management.
Pancreatic neuroendocrine tumors and intraductal papillary mucinous neoplasm of the pancreas: a systematic review
