Proteomics of Pancreatic Neuroendocrine Tumors: A Systematic Review

2020 ◽  
Vol 27 (12) ◽  
pp. 1276-1287
Author(s):  
Brigida Anna Maiorano ◽  
Giovanni Schinzari ◽  
Sabrina Chiloiro ◽  
Felicia Visconti ◽  
Domenico Milardi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Prognostic Markers ◽  
State Of The Art ◽  
Therapeutic Targets ◽  
The State ◽  
Pancreatic Neuroendocrine Tumors ◽  
Rare Tumors ◽  
Personalized Approach ◽  
Future Management

Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning (F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques represent therefore promising approaches for the future management of PanNETs. We conducted a systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis, the prognosis and the detection of therapeutic targets. However, further studies are required. It is also warranted to standardize the analysis methods and the collection techniques, in order to validate proteins with a relevance in the personalized approach to PanNETs management.

scholarly journals A Systematic Review of Recommender Systems and Their Applications in Cybersecurity

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5248
Author(s):  
Aleksandra Pawlicka ◽  
Marek Pawlicki ◽  
Rafał Kozik ◽  
Ryszard S. Choraś
Keyword(s):  
Systematic Review ◽  
Recommender Systems ◽  
Recommender System ◽  
State Of The Art ◽  
The State ◽  
Advantages And Disadvantages ◽  
Comprehensive Survey ◽  
Security Concerns ◽  
Valuable Role

This paper discusses the valuable role recommender systems may play in cybersecurity. First, a comprehensive presentation of recommender system types is presented, as well as their advantages and disadvantages, possible applications and security concerns. Then, the paper collects and presents the state of the art concerning the use of recommender systems in cybersecurity; both the existing solutions and future ideas are presented. The contribution of this paper is two-fold: to date, to the best of our knowledge, there has been no work collecting the applications of recommenders for cybersecurity. Moreover, this paper attempts to complete a comprehensive survey of recommender types, after noticing that other works usually mention two–three types at once and neglect the others.

scholarly journals State-of-the-art Imaging of Pancreatic Neuroendocrine Tumors

2016 ◽  
Vol 25 (2) ◽  
pp. 375-400 ◽  
Author(s):  
Eric P. Tamm ◽  
Priya Bhosale ◽  
Jeffrey H. Lee ◽  
Eric M. Rohren
Keyword(s):  
Neuroendocrine Tumors ◽  
State Of The Art ◽  
Pancreatic Neuroendocrine Tumors

scholarly journals Should surgery be conducted for small nonfunctioning pancreatic neuroendocrine tumors: a systematic review

Oncotarget ◽  
2017 ◽  
Vol 8 (21) ◽  
pp. 35368-35375 ◽  
Author(s):  
Jingfei Guo ◽  
Jianjun Zhao ◽  
Xinyu Bi ◽  
Zhiyu Li ◽  
Zhen Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Pancreatic Neuroendocrine Tumors

Current practices of management of congenital Cytomegalovirus infection during pregnancy and childhood: systematic review protocol

2020 ◽  
Author(s):  
Claire Perillaud Dubois ◽  
Drifa Belhadi ◽  
Cédric Laouénan ◽  
Laurent Mandelbrot ◽  
Christelle Vauloup-Fellous ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
State Of The Art ◽  
Grey Literature ◽  
The State ◽  
Cochrane Library ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Congenital Cmv ◽  
Current Practices

Abstract Background: Congenital CMV infection is the first worldwide cause of congenital viral infection and a major cause of sensorineural hearing loss and mental retardation. As systematic screening of pregnant women and newborns is still debated in many countries, this systematic review aims to provide the state of the art on current practices concerning management of congenital CMV infection.Methods: We will perform electronically searches on MEDLINE, EMBASE, Cochrane Library (CENTRAL), ClinicalTrials.gov, Web of Science and hand searches in grey literature. Interventions regarding biological, imaging, and therapeutic management of infected pregnant women, fetuses and neonates/children (from birth to 6 years old) will be studied in this systematic review. Study screening will be performed in duplicate by two independent reviewers and risk of bias will be evaluated with the ROBINS-I tool. Discussion: This review will provide the state of the art of current management of congenital CMV infection in pregnant women, fetuses, neonates and children until 6 years old, in order to have an overview of current practices of congenital CMV infection.Systematic review registration: PROSPERO CRD42019124342

scholarly journals Pancreatic neuroendocrine tumors and intraductal papillary mucinous neoplasm of the pancreas: a systematic review

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S562
Author(s):  
R. Latorre Fragua ◽  
A. Manuel Vazquez ◽  
C. Ramiro Pérez ◽  
C. Garcia Amador ◽  
B. Gonzalez Sierra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Pancreatic Neuroendocrine Tumors ◽  
Mucinous Neoplasm

scholarly journals Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5117
Author(s):  
Chandra K. Maharjan ◽  
Po Hien Ear ◽  
Catherine G. Tran ◽  
James R. Howe ◽  
Chandrikha Chandrasekharan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Neuroendocrine Tumors ◽  
Molecular Mechanisms ◽  
Treatment Options ◽  
Somatostatin Receptor ◽  
Therapeutic Targets ◽  
Model Systems ◽  
Pancreatic Neuroendocrine Tumors ◽  
Acquired Drug Resistance ◽  
Molecular Alterations

Pancreatic neuroendocrine tumors (pNETs) are unique, slow-growing malignancies whose molecular pathogenesis is incompletely understood. With rising incidence of pNETs over the last four decades, larger and more comprehensive ‘omic’ analyses of patient tumors have led to a clearer picture of the pNET genomic landscape and transcriptional profiles for both primary and metastatic lesions. In pNET patients with advanced disease, those insights have guided the use of targeted therapies that inhibit activated mTOR and receptor tyrosine kinase (RTK) pathways or stimulate somatostatin receptor signaling. Such treatments have significantly benefited patients, but intrinsic or acquired drug resistance in the tumors remains a major problem that leaves few to no effective treatment options for advanced cases. This demands a better understanding of essential molecular and biological events underlying pNET growth, metastasis, and drug resistance. This review examines the known molecular alterations associated with pNET pathogenesis, identifying which changes may be drivers of the disease and, as such, relevant therapeutic targets. We also highlight areas that warrant further investigation at the biological level and discuss available model systems for pNET research. The paucity of pNET models has hampered research efforts over the years, although recently developed cell line, animal, patient-derived xenograft, and patient-derived organoid models have significantly expanded the available platforms for pNET investigations. Advancements in pNET research and understanding are expected to guide improved patient treatments.

scholarly journals Rise of multiattribute decision‐making in combating COVID‐19: A systematic review of the state‐of‐the‐art literature

2021 ◽  
Author(s):  
Mohammed Assim Alsalem ◽  
Rawia Mohammed ◽  
Osamah Shihab Albahri ◽  
Aws Alaa Zaidan ◽  
Abdullah Hussein Alamoodi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Decision Making ◽  
State Of The Art ◽  
The State

scholarly journals Cystic pancreatic neuroendocrine tumors (cPNETs): a systematic review and meta-analysis of case series

2017 ◽  
Vol 109 ◽  
Author(s):  
Luis Hurtado-Pardo ◽  
Javier A. Cienfuegos ◽  
Miguel Ruiz-Canela ◽  
Pablo Panadero ◽  
Alberto Benito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Meta Analysis ◽  
Case Series ◽  
Pancreatic Neuroendocrine Tumors
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