scholarly journals B-PO01-105 FLUOROLESS GANGLIONATED PLEXUS ABLATION FOR SYMPTOMATIC BRADYCARDIA

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S93
Author(s):  
Sri Sundaram ◽  
Dan Alyesh ◽  
Benjamin Jones ◽  
Thomas Rogers ◽  
Tolga Aksu ◽  
...  
Keyword(s):  
Symptomatic Bradycardia ◽  
Ganglionated Plexus

Sympathetic input to ganglia of the guinea pig sphincter of Oddi

1994 ◽  
Vol 266 (6) ◽  
pp. G1162-G1169 ◽  
Author(s):  
D. G. Wells ◽  
G. M. Mawe
Keyword(s):  
Sphincter Of Oddi ◽  
Nerve Fibers ◽  
Excitatory Postsynaptic Potential ◽  
Inhibitory Neurotransmitter ◽  
Fiber Tracts ◽  
Inhibitory Postsynaptic Potentials ◽  
Dopamine Beta Hydroxylase ◽  
Staining Techniques ◽  
The Uk ◽  
Ganglionated Plexus

Intracellular recording and immunohistochemical staining techniques were used to establish whether sphincter of Oddi (SO) ganglia are a target of sympathetic input to this region. Norepinephrine (0.01-10.0 microM) decreased the amplitude of the nicotinic fast excitatory postsynaptic potential (EPSP) evoked by stimulation of interganglionic fiber tracts, with a half-maximal inhibitory concentration (EC50) of 300 nM. Norepinephrine did not alter the responsiveness of the neurons to acetylcholine. The alpha 2-adrenoreceptor agonist UK-14304 mimicked the norepinephrine-induced effect with a EC50 of 2.5 nM, whereas alpha 1- and beta-adrenoreceptor agonists had no effect on the EPSP. The alpha 2-adrenoreceptor antagonist idazoxan (1.0 microM) inhibited the UK-14304 response, with a dissociation constant of 1.0 nM. Release of endogenous catecholamines, by the addition of tyramine (100 microM) to the bath, caused an idazoxan-sensitive decrease in the amplitude of the fast EPSP. In the minority of SO neurons that exhibited inhibitory postsynaptic potentials (IPSPs), norepinephrine caused a hyperpolarization of the membrane potential. The IPSP and the norepinephrine-induced hyperpolarization were inhibited by alpha 2-adrenoreceptor antagonists. Desipramine (1.0 microM), an uptake inhibitor, reversibly increased the amplitude of the IPSP. Immunoreactivities for tyrosine hydroxylase and dopamine beta-hydroxylase were coexistent in nerve fibers and nonexistent in cell bodies in the ganglionated plexus of the SO. The results of this study indicate that norepinephrine acts pre- and postsynaptically as an inhibitory neurotransmitter in SO ganglia.

scholarly journals Seasonal Distribution of Pacemaker Implantation for Symptomatic Bradycardia

2003 ◽  
Vol 44 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Chien-Jen Chen ◽  
Mien-Cheng Chen ◽  
Hon-Kan Yip ◽  
Hsueh-Wen Chang ◽  
Cheng-I Cheng ◽  
...  
Keyword(s):  
Pacemaker Implantation ◽  
Seasonal Distribution ◽  
Symptomatic Bradycardia

Initial Experience with Fractionation Mapping in the Identification of Vagal Ganglionated Plexus During Cardioneuroablation

2021 ◽  
Vol 34 (3) ◽  
pp. 105-112
Author(s):  
Fabricio Vassallo ◽  
Edevaldo da Silva ◽  
Lucas Luis Meigre ◽  
Christiano Cunha ◽  
Eduardo Serpa ◽  
...  
Keyword(s):  
Sinus Bradycardia ◽  
Stress Test ◽  
Pacemaker Implantation ◽  
Holter Monitoring ◽  
Initial Experience ◽  
Short Term ◽  
Mapping Software ◽  
Anatomical Basis ◽  
Ganglionated Plexus ◽  
Treadmill Stress Test

This is a series case report of five symptomatic patients presented with diagnosis of sinus bradycardia, first and second degrees atrioventricular (AV) blocks, that were referred to pacemaker implantation. During the screening, a functional cause for the bradycardia and AV blocks were documented by treadmill stress test, 24-hour Holter monitoring and atropine test. After the confirmation of the diagnosis, patients were submitted to cardioneuroablation on an anatomical basis supported by a tridimensional electroanatomical fractionation mapping software. The technique and the acute and short-term results of the cardioneuroablation are described.

Morphological and quantitative study of ganglionated plexus of Calomys callosus trachea

2008 ◽  
Vol 144 (1-2) ◽  
pp. 30-35
Author(s):  
Vânia C.G. Furlani ◽  
Thiago S. Habacuque ◽  
Romeu R. Souza ◽  
Edson A. Liberti
Keyword(s):  
Quantitative Study ◽  
Calomys Callosus ◽  
Ganglionated Plexus

Activity of in vivo canine cardiac plexus neurons

1988 ◽  
Vol 255 (4) ◽  
pp. H789-H800 ◽  
Author(s):  
M. Gagliardi ◽  
W. C. Randall ◽  
D. Bieger ◽  
R. D. Wurster ◽  
D. A. Hopkins ◽  
...  
Keyword(s):  
Cardiac Cycle ◽  
Pulmonary Veins ◽  
Systolic Pressure ◽  
Identified Neurons ◽  
Fat Pad ◽  
Respiratory Dynamics ◽  
The Right ◽  
Ganglion Neurons ◽  
Ganglionated Plexus

The activity of 394 spontaneously active neurons located in the ganglionated plexus of the ventral epicardial fat pad overlying the right atrium and pulmonary veins was recorded. Ganglia that contained various numbers of neurons, many with two or more nucleoli, were identified adjacent to the recording sites. Spontaneous activity was correlated with the cardiac cycle in 39% and with the respiratory cycle in 8% of the identified neurons. Neuronal activity occurred in specific phases of the cardiac cycle when arterial pressure was between approximately 70 and 175 mmHg. During increases in systolic pressure induced by positive inotropic agents or aortic occlusion, responses of neurons that displayed cardiovascular-related activity were enhanced. These responses persisted after acute decentralization. The activity of 14% of all identified neurons was altered when discrete regions of the heart, great thoracic vessels, or lungs were mechanically distorted by gentle touch. Trains of stimuli, but not single stimuli, delivered to the vagosympathetic complexes, stellate ganglia, or cardiopulmonary nerves activated ganglionic neurons in intact or acutely decentralized preparations. It is concluded that the activity of some cardiac ganglion neurons is related to cardiovascular or respiratory dynamics and that some of these neurons receive inputs from sympathetic and parasympathetic efferent axons as well as from cardiac mechanoreceptors.

scholarly journals Symptomatic Bradycardia in Covid-19 Hospitalized Patients: a Case Series

2021 ◽  
Author(s):  
Muzakkir Amir ◽  
Hendry Yoseph ◽  
Aulia Thufael Al Farisi ◽  
James Klemens Phieter Phie ◽  
Andi Tiara Salengke Adam
Keyword(s):  
Case Series ◽  
Hospitalized Patients ◽  
Symptomatic Bradycardia

scholarly journals Feasibility and Safety of Left Bundle Branch Pacing for Advance Aged Patients: A Multicenter Comparative Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhongyuan Ren ◽  
Binni Cai ◽  
Songyun Wang ◽  
Peng Jia ◽  
Yang Chen ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Effective Means ◽  
The Elderly ◽  
Elderly Group ◽  
Complication Rates ◽  
Related Complication ◽  
Aged Patients ◽  
Fluoroscopic Time ◽  
Symptomatic Bradycardia

Background: Left bundle branch pacing (LBBP) has been shown to be a safe and effective means to achieve physiological pacing. However, elderly patients have increased risks from invasive procedures and the risk of LBBP in elderly patients is not known. We aimed to investigate the safety and efficacy of LBBP in elderly patients >80 years of age.Methods: From December 2017 to June 2019, 346 consecutive patients with symptomatic bradycardia, 184 patients under 80 years of age and 162 over 80 years, were included and underwent LBBP. The safety and prognosis of LBBP were comparatively evaluated by measured pacing parameters, periprocedural complications, and follow-up clinical events.Results: Compared with the younger, the elderly group had worse baseline cardiac and renal function. LBBP was achieved successfully in both groups with comparable fluoroscopic time and paced QRS duration (110.0 [102.0, 118.0] ms for the young vs. 110.0 [100.0, 120.0] ms for the elderly, P = 0.874). Through a follow-up of 20.0 ± 6.1 months, pacing parameters were stable while higher threshold and impedance were observed in the elderly group. In the evaluation of safety, overall procedure-related complication rates were comparable (4.4 vs. 3.8%, young vs. elderly). For prognosis, similar rates of major adverse cardiocerebrovascular events (7.1 vs. 11.9%, young vs. elderly) were observed.Conclusions: Compared to younger patients, LBBP could achieve physiological pacing in patients over 80 with comparable midterm safety and prognosis. Long-term safety and benefits of LBBP, however, necessitate further evaluation.

scholarly journals Absence of Ganglionated Plexus in Bullfrog Gallbadder.

1998 ◽  
Vol 34 (5/6) ◽  
pp. 185-191 ◽  
Author(s):  
Masahide YOSHIDA ◽  
Takemi KOEDA
Keyword(s):  
Ganglionated Plexus
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