The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer

2017 ◽  
Vol 69 ◽  
pp. 110-117 ◽  
Author(s):  
Kai Wang ◽  
Tiansheng Shen ◽  
Gene P. Siegal ◽  
Shi Wei
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer

2015 ◽  
Vol 7 (4) ◽  
pp. 232-241
Author(s):  
Koo Si-Lin ◽  
Loh Kiley ◽  
Sulastri Kamis ◽  
Jabed Iqbal ◽  
Rebecca Dent ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Prognostic value of routinely determined tumor infiltrating lymphocytes in triple-negative breast cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1125-1125 ◽  
Author(s):  
Jana Pahole Golicnik ◽  
Barbara Gazic ◽  
Tanja Ovcaricek ◽  
Erika Matos ◽  
Simona Borstnar
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a meta-analysis

2014 ◽  
Vol 148 (3) ◽  
pp. 467-476 ◽  
Author(s):  
Ezzeldin M. Ibrahim ◽  
Meteb E. Al-Foheidi ◽  
Mubarak M. Al-Mansour ◽  
Ghieth A. Kazkaz
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals Tumor-infiltrating lymphocytes and CD8+ T cells predict survival of triple-negative breast cancer

2019 ◽  
Vol 145 (12) ◽  
pp. 3105-3114 ◽  
Author(s):  
H. Vihervuori ◽  
T. A. Autere ◽  
H. Repo ◽  
S. Kurki ◽  
L. Kallio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
T Cells ◽  
Inflammatory Response ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Cancer Cell Proliferation ◽  
Infiltrating Lymphocytes

Abstract Purpose Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. Methods TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tissue microarrays. Results Deficiency of stromal TILs and low number of CD8+ T cells independently predicted mortality in TNBC (HR 2.4, p 0.02 and HR 2.1, p 0.02, respectively). Each 10% decrease in stromal TILs resulted in 20% increased risk of mortality. An average of 13.2-year survival difference was observed between the majority (> 75%) of patients with low (< 14% of TILs) vs high (≥ 14% of TILs) frequency of CD8+ T cells. The prognostic value of TILs and CD8+ T cells varied when evaluated in different tumor compartments. TILs and CD8+ T cells were significantly associated with Securin and Separase, essential regulators of metaphase–anaphase transition of the cell cycle. Discussion TILs and CD8+ T cells provide additional prognostic value to the established clinical prognostic markers in TNBC. However, possible clinical applications would still benefit from systematic guidelines for evaluating tumor inflammatory response. Increasing understanding on the interactions between the regulation of cancer cell proliferation and inflammatory response may in future advance treatment of TNBC.

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