Evaluation of Albizia procera gum as compression coating material for colonic delivery of budesonide

2013 ◽  
Vol 61 ◽  
pp. 333-339 ◽  
Author(s):  
Lalduhsanga Pachuau ◽  
Bhaskar Mazumder
Keyword(s):  
Coating Material ◽  
Colonic Delivery ◽  
Compression Coating ◽  
Albizia Procera

The Application and Functional Progress of γ-Poly-Glutamic Acid in Food: A Mini-Review

2020 ◽  
Vol 26 (41) ◽  
pp. 5347-5352
Author(s):  
Guoliang Wang ◽  
Qing Liu ◽  
Ying Wang ◽  
Jingyuan Li ◽  
Yue Chen ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Food Industry ◽  
Water Solubility ◽  
Drug Carrier ◽  
Physical Property ◽  
Coating Material ◽  
Vaccine Adjuvant ◽  
Food Ingredient ◽  
Naturally Occurring

γ-Poly-glutamic acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. As a biopolymer substance, γ-PGA possesses a few predominant features containing good water solubility, biocompatibility, degradability and non-toxicity. Based on this, γ-PGA can be used in pharmaceutical, such as drug carrier/deliverer, vaccine adjuvant, and coating material for microencapsulation, etc. Moreover, it has also been applied in a broad range of industrial fields including food, medicine, bioremediation, cosmetics, and agriculture. Especially, γ-PGA is an extremely promising food ingredient. In this mini-review, our aim is to review the function and application progress of γ-PGA in the food industry: e.g., improving taste and flavor, enhancing physical property, and promoting health.

Desirability Based Optimization of New Mesalazine Modified Release Formulations: Compression Coated Tablets and Mini Tablets in Capsules

2020 ◽  
Vol 17 (2) ◽  
pp. 114-123
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Yannis Dotsikas
Keyword(s):  
Gastrointestinal Tract ◽  
Experimental Design ◽  
Desirability Function ◽  
Symptomatic Treatment ◽  
Mixture Design ◽  
Upper Gastrointestinal Tract ◽  
Modified Release ◽  
Aminosalicylic Acid ◽  
Colonic Delivery ◽  
Upper Gastrointestinal

Background: Mesalazine (5-aminosalicylic acid, 5-ASA) is a drug substance with an antiinflammatory activity, which is mainly used in the symptomatic treatment of diseases, such as Ulcerative Colitis, the Crohn's disease and the idiopathic inflammatory bowel disease. Mesalazine exerts its effect locally in the inflamed area of the intestine and not through systematic absorption, therefore the investigation of its release characteristics from solid pharmaceutical formulations is of great importance. Objective: The development of novel mesalazine modified release formulations with improved properties, regarding drug release in the gastrointestinal tract, by utilisation of the Design of Experiments (DoE) approach. Methods: D-optimal experimental design was applied. A Simplex Lattice mixture design was used for the development of suitable capsules containing 4 mini tablets and a D-optimal mixture design was used for compression-coated tablets, with the following characteristics: ≤10% release in 2 h, to minimize its degradation in the upper gastrointestinal tract, 20-40% release in 5 h for mesalazine administration in the small intestine, and quantitative release in 12 h for colonic delivery. The dissolution experiments were conducted in gastrointestinal-like fluids and pectinases to simulate the pectinolytic enzymes present in the colon. Results: The optimal compositions were reached via the desirability function, as a compromise to the different responses. The optimal solutions for both formulations led to colon-specific delivery of the active substance with minimal 5-ASA release in the upper gastrointestinal tract and appeared to conform with the pre-determined characteristics. Hard gelatin capsules, when filled with mini-tablets led to the aimed modified release profile, having sigmoidal characteristics and compression coated tablets led to colonic delivery. Conclusion: Two novel mesalazine formulations were developed with the desirable colonic release, by conducting a minimal number of experiments, as suggested by DoE experimental design.

scholarly journals An alternative coating material for gas turbine blade for aerospace applications

2020 ◽  
Vol 1706 ◽  
pp. 012183
Author(s):  
Yajnesh M Poojari ◽  
Koustubh S Annigeri ◽  
Nilesh Bandekar ◽  
Kiran U Annigeri ◽  
Vinayak badiger ◽  
...  
Keyword(s):  
Gas Turbine ◽  
Turbine Blade ◽  
Coating Material ◽  
Gas Turbine Blade ◽  
Aerospace Applications

Effect of the coating material compositions on the life of gas turbine hot section components

2021 ◽  
Author(s):  
U. Harish ◽  
M. Mruthunjaya ◽  
K. Naresha ◽  
G. Madhu
Keyword(s):  
Gas Turbine ◽  
Coating Material

scholarly journals (Hydroxy)apatite on cement: insights into a new surface treatment

2021 ◽  
Author(s):  
Ronald Joseph Turner ◽  
Pieter Bots ◽  
Alan Richardson ◽  
Paul Bingham ◽  
Alex Scrimshire ◽  
...  
Keyword(s):  
Low Temperature ◽  
Surface Treatment ◽  
Nuclear Waste ◽  
Environmental Remediation ◽  
Coating Material ◽  
Hydroxy Apatite ◽  
Nuclear Waste Storage ◽  
Waste Storage ◽  
Architectural Preservation

(Hydroxy)apatite [Ca10(PO4)6(OH)2], has emerging potential as a cement coating material, with applications in environmental remediation, nuclear waste storage and architectural preservation. In these low temperature environments and when precipitating from...

Investigation of binary coating material mixtures using grazing incidence EUV-reflectometry

2014 ◽  
Author(s):  
I. Balasa ◽  
X. Neiers ◽  
M. Mende ◽  
L. Jensen ◽  
D. Ristau
Keyword(s):  
Grazing Incidence ◽  
Coating Material
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