Mutation analysis of the interactions between Mycobacterium tuberculosis caseinolytic protease C1 (ClpC1) and ecumicin

2017 ◽  
Vol 101 ◽  
pp. 348-357 ◽  
Author(s):  
In-Pil Jung ◽  
Na-Reum Ha ◽  
A-Ru Kim ◽  
Sang-Heon Kim ◽  
Moon-Young Yoon
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mutation Analysis ◽  
Caseinolytic Protease ◽  
Protease C1

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

2011 ◽  
Vol 50 (26) ◽  
pp. 5889-5891 ◽  
Author(s):  
Esther K. Schmitt ◽  
Meliana Riwanto ◽  
Vasan Sambandamurthy ◽  
Silvio Roggo ◽  
Charlotte Miault ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Natural Product ◽  
Caseinolytic Protease

scholarly journals Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Michelle Yee ◽  
Pooja Gopal ◽  
Thomas Dick
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Resistance Mechanisms ◽  
Missense Mutations ◽  
Content Type ◽  
Bioactive Component ◽  
Caseinolytic Protease ◽  
Additional Resistance ◽  
Resistant Strains ◽  
Type Strains ◽  
Pyrazinoic Acid

ABSTRACT Previously, we showed that mutations in Mycobacterium tuberculosis panD, involved in coenzyme A biosynthesis, cause resistance against pyrazinoic acid, the bioactive component of the prodrug pyrazinamide. To identify additional resistance mechanisms, we isolated mutants resistant against pyrazinoic acid and subjected panD wild-type strains to whole-genome sequencing. Eight of the nine resistant strains harbored missense mutations in the unfoldase ClpC1 associated with the caseinolytic protease complex.

scholarly journals Discrimination of Multidrug-ResistantMycobacterium tuberculosis IS6110 Fingerprint Subclusters by rpoB Gene Mutation Analysis

1999 ◽  
Vol 37 (9) ◽  
pp. 3022-3024 ◽  
Author(s):  
Isabel Portugal ◽  
Sara Maia ◽  
José Moniz-Pereira
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Gene Mutation ◽  
Mutation Analysis ◽  
Gene Mutations ◽  
Rpob Gene ◽  
Gene Mutation Analysis

The rpoB gene mutations in a 69-bp region of the gene, resulting in resistance to rifampin, were used to discriminate betweenMycobacterium tuberculosis IS6110 fingerprint subclusters. These subclusters exhibited identical IS6110fragments or had one or two additional fragments. In the two major subclusters all the analyzed strains have the same variantrpoB allele but are different from each other, suggesting the occurrence of independent outbreaks.

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

2011 ◽  
Vol 123 (26) ◽  
pp. 6011-6013 ◽  
Author(s):  
Esther K. Schmitt ◽  
Meliana Riwanto ◽  
Vasan Sambandamurthy ◽  
Silvio Roggo ◽  
Charlotte Miault ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Natural Product ◽  
Caseinolytic Protease

Determination of haemophilia A carrier status by mutation analysis

Haemophilia ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 20-25 ◽  
Author(s):  
S. Oranwiroon ◽  
V. Akkarapatumwong ◽  
P. Pung-Amritt ◽  
A. Treesucon ◽  
G. Veerakul ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Carrier Status ◽  
Haemophilia A

homeodomain mutation analysis in patients with Müllerian system anomalies

1998 ◽  
Vol 5 (1) ◽  
pp. 140A-140A ◽  
Author(s):  
J STELLING ◽  
B BHAGAVATH ◽  
M GRAY ◽  
R REINDOLLAR
Keyword(s):  
Mutation Analysis
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