Evaluation of thiazolidinone derivatives as a new class of mushroom tyrosinase inhibitors

2018 ◽  
Vol 108 ◽  
pp. 205-213 ◽  
Author(s):  
Mehrnaz Rezaei ◽  
Hamed Taj Mohammadi ◽  
Atiyeh Mahdavi ◽  
Mostafa Shourian ◽  
Hossein Ghafouri
Keyword(s):  
Mushroom Tyrosinase ◽  
New Class ◽  
Tyrosinase Inhibitors

ChemInform Abstract: Discovery of 4-Functionalized Phenyl-O-β-D-glycosides as a New Class of Mushroom Tyrosinase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 41 (9) ◽  
Author(s):  
Wei Yi ◽  
Rihui Cao ◽  
Huan Wen ◽  
Qin Yan ◽  
Binhua Zhou ◽  
...  
Keyword(s):  
Mushroom Tyrosinase ◽  
New Class ◽  
Tyrosinase Inhibitors

Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors

2009 ◽  
Vol 19 (21) ◽  
pp. 6157-6160 ◽  
Author(s):  
Wei Yi ◽  
Rihui Cao ◽  
Huan Wen ◽  
Qin Yan ◽  
Binhua Zhou ◽  
...  
Keyword(s):  
Mushroom Tyrosinase ◽  
New Class ◽  
Tyrosinase Inhibitors

Evaluation of Cytotoxic and Tyrosinase Inhibitory Activities of 2-phenoxy(thiomethyl) pyridotriazolopyrimidines: In Vitro and Molecular Docking Studies

2020 ◽  
Vol 20 (14) ◽  
pp. 1714-1721
Author(s):  
Hatem A. Abuelizz ◽  
El Hassane Anouar ◽  
Mohamed Marzouk ◽  
Mizaton H. Hasan ◽  
Siti R. Saleh ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Kojic Acid ◽  
Docking Studies ◽  
Breast Adenocarcinoma ◽  
Amino Acid Residues ◽  
New Class ◽  
Structure Activity ◽  
Tyrosinase Inhibitors ◽  
Mcf 7

Background: The use of tyrosinase has confirmed to be the best means of recognizing safe, effective, and potent tyrosinase inhibitors for whitening skin. Twenty-four 2-phenoxy(thiomethyl)pyridotriazolopyrimidines were synthesized and characterized in our previous studies. Objective: The present work aimed to evaluate their cytotoxicity against HepG2 (hepatocellular carcinoma), A549 (pulmonary adenocarcinoma), MCF-7 (breast adenocarcinoma) and WRL 68 (embryonic liver) cell lines. Methods: MTT assay was employed to investigate the cytotoxicity, and a tyrosinase inhibitor screening kit was used to evaluate the Tyrosinase (TYR) inhibitory activity of the targets. Results: The tested compounds exhibited no considerable cytotoxicity, and nine of them were selected for a tyrosinase inhibitory test. Compounds 2b, 2m, and 5a showed good inhibitory percentages against TYR compared to that of kojic acid (reference substance). Molecular docking was performed to rationalize the Structure-Activity Relationship (SAR) of the target pyridotriazolopyrimidines and analyze the binding between the docked-selected compounds and the amino acid residues in the active site of tyrosinase. Conclusion: The target pyridotriazolopyrimidines were identified as a new class of tyrosinase inhibitors.

scholarly journals 4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Toxoplasma gondii agents

2021 ◽  
Vol 36 (1) ◽  
pp. 1145-1164
Author(s):  
Adrian Bekier ◽  
Lidia Węglińska ◽  
Agata Paneth ◽  
Piotr Paneth ◽  
Katarzyna Dzitko
Keyword(s):  
Toxoplasma Gondii ◽  
New Class ◽  
Tyrosinase Inhibitors

scholarly journals Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Hooshang Hamidian
Keyword(s):  
Kojic Acid ◽  
Azo Compounds ◽  
The Novel ◽  
Mushroom Tyrosinase ◽  
Reference Standard ◽  
Tyrosinase Inhibition ◽  
H Nmr ◽  
Ft Ir ◽  
Tyrosinase Inhibitors ◽  
C Nmr

In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, andN,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a–5f) showed the most potent mushroom tyrosinase inhibition (IC50values in the range of 4.39 ± 0.76–1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor. All the novel compounds were characterized by FT-IR,1H NMR,13C NMR, and elemental analysis.

scholarly journals Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0178069 ◽  
Author(s):  
Zaman Ashraf ◽  
Muhammad Rafiq ◽  
Humaira Nadeem ◽  
Mubashir Hassan ◽  
Samina Afzal ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Mushroom Tyrosinase ◽  
Molecular Docking Studies ◽  
Tyrosinase Inhibitors

Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants

2009 ◽  
Vol 117 (3) ◽  
pp. 381-386 ◽  
Author(s):  
Wei Yi ◽  
Xiaoqin Wu ◽  
Rihui Cao ◽  
Huacan Song ◽  
Lin Ma
Keyword(s):  
Vitamin C ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibitors

New class of alkynyl glycoside analogues as tyrosinase inhibitors

2020 ◽  
Vol 30 (15) ◽  
pp. 127276
Author(s):  
Natthiya Saehlim ◽  
Anan Athipornchai ◽  
Uthaiwan Sirion ◽  
Rungnapha Saeeng
Keyword(s):  
New Class ◽  
Tyrosinase Inhibitors
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