Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering

2018 ◽  
Vol 119 ◽  
pp. 945-953 ◽  
Author(s):  
Francesco Carfì Pavia ◽  
Gioacchino Conoscenti ◽  
Silvia Greco ◽  
Vincenzo La Carrubba ◽  
Giulio Ghersi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Poly Lactic Acid ◽  
In Vitro Test ◽  
Vitro Test

scholarly journals Calcium Silicate/Chitosan-Coated Electrospun Poly (lactic acid) Fibers for Bone Tissue Engineering

2017 ◽  
Author(s):  
Chu-Jung Su ◽  
Ming-Gene Tu ◽  
Li-Ju Wei ◽  
Tuan-Ti Hsu ◽  
Chia-Tze Kao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Silicate ◽  
Composite Scaffold ◽  
Organic Polymer ◽  
Poly Lactic Acid ◽  
Ideal Candidate

Electrospinning is the versatile technique to generate large quantities of micro- or nano-fibers from a wide variety of shapes and sizes of polymer. Natural bone is a hierarchically composites with the dispersion of inorganic ceramic along organic polymer. The aim of this study, the electrospun poly (lactic acid) (PLA) mats coated with chitosan (CH) and calcium silicate (CS) powder were fabricated. The morphology, chemical composition, and surface properties of CS/CH-PLA composites were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. In vitro, the CS/CH-coated PLA mats increased the formation of apatite on the surface when soaking in cell cultured medium. During culture, the adhesion and proliferation of the human mesenchymal stem cells (hMSCs) cultured on CS/CH-PLA were significantly promoted relative to those on PLA. Collagen I and fibronectin levels and promoted cell adhesion were observed upon an increase in CS content. Further, compared to PLA mats without CS/CH, CS10 and CS15 mats markedly enhanced the proliferation of hMSCs as well as their osteogenesis properties, which was characterized by bone-related gene expression. Our results demonstrated that the biodegradable and electroactive CS/CH-PLA mats had potential application as an ideal candidate for bone tissue engineering. Together, findings from this study clearly demonstrated that PLLA-C2S composite scaffold may function as an ideal candidate for bone tissue engineering.

scholarly journals Drug Release from Electrospun Poly(Lactic Acid) Membranes and Their Cell Viability in Vitro Test

2012 ◽  
Vol 44 ◽  
pp. 866-868 ◽  
Author(s):  
A.P.S. Immich ◽  
M. Lis ◽  
L.H. Catalani ◽  
R.L. Boemo ◽  
J.A. Tornero
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Cell Viability ◽  
Poly Lactic Acid ◽  
In Vitro Test ◽  
Vitro Test

3D-poly (lactic acid) scaffolds coated with gelatin and mucic acid for bone tissue engineering

2020 ◽  
Vol 162 ◽  
pp. 523-532 ◽  
Author(s):  
B. Ashwin ◽  
B. Abinaya ◽  
T.P. Prasith ◽  
S. Viji Chandran ◽  
L. Roshini Yadav ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Poly Lactic Acid ◽  
Mucic Acid
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