Dual drug delivery system of photothermal-sensitive carboxymethyl chitosan nanosphere for photothermal-chemotherapy

2020 ◽  
Vol 163 ◽  
pp. 156-166 ◽  
Author(s):  
Xianwu Liu ◽  
Zuyu He ◽  
Yu Chen ◽  
Chuang Zhou ◽  
Chao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Chitosan ◽  
Dual Drug

Cell-mediated BMP-2 release from a novel dual-drug delivery system promotes bone formation

2013 ◽  
Vol 25 (12) ◽  
pp. 1412-1421 ◽  
Author(s):  
Tie Liu ◽  
Gang Wu ◽  
Yuanna Zheng ◽  
Daniel Wismeijer ◽  
Vincent Everts ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dual Drug

Smart releasing electrospun nanofibers—poly: L.lactide fibers as dual drug delivery system for biomedical application

2020 ◽  
Vol 16 (1) ◽  
pp. 015022
Author(s):  
Katharina Wulf ◽  
Daniela Arbeiter ◽  
Claudia Matschegewski ◽  
Michael Teske ◽  
Jennifer Huling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Application ◽  
Electrospun Nanofibers ◽  
Dual Drug

Charge-conversion and ultrasound-responsive O-carboxymethyl chitosan nanodroplets for controlled drug delivery

Nanomedicine ◽  
2019 ◽  
Vol 14 (19) ◽  
pp. 2549-2565 ◽  
Author(s):  
Dong Meng ◽  
Lu Guo ◽  
Dandan Shi ◽  
Xiao Sun ◽  
Mengmeng Shang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Ultrasound Imaging ◽  
Delivery System ◽  
Cell Interaction ◽  
Carboxymethyl Chitosan ◽  
Ultrasound Exposure ◽  
Interaction Efficiency

Aim: O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS NDs) and doxorubicin-loading O-carboxymethyl chitosan nanodroplets were synthesized and functionally tested as drug delivery system in vitro. Materials & methods: The characteristics, charge conversion, stability, cytotoxicity, ultrasound imaging ability, interaction with tumor cells of the nanodroplets and eradication on tumor cells of the doxorubicin-loaded nanodroplets were investigated. Results: O-CS NDs (below 200 nm) achieved higher tumor cellular associations at acidic pH, with great serum stability, pH-dependent charge conversion and good ultrasound imaging ability. Doxorubicin-loading O-carboxymethyl chitosan nanodroplets exhibited strong cytotoxicity on PC-3 cells with ultrasound exposure. Conclusion: These stable, safe and smart O-CS NDs may be a promising approach to improve cell interaction efficiency as an ultrasound imaging and cancer-targeting drug delivery system.

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