Immune-adjuvant activity of lentinan-modified calcium carbonate microparticles on a H5N1 vaccine

2020 ◽  
Vol 163 ◽  
pp. 1384-1392
Author(s):  
Jin He ◽  
Zhenguang Liu ◽  
Wenming Jiang ◽  
Tianyu Zhu ◽  
Adelijiang Wusiman ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Adjuvant Activity ◽  
Immune Adjuvant ◽  
H5n1 Vaccine

scholarly journals Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0143370 ◽  
Author(s):  
Fumito Ito ◽  
Amy W. Ku ◽  
Mark J. Bucsek ◽  
Jason B. Muhitch ◽  
Trupti Vardam-Kaur ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Radiofrequency Ablation ◽  
Adjuvant Activity ◽  
Systemic Recurrence ◽  
Immune Adjuvant

Enhanced Immune Adjuvant Activity of Aluminum Oxyhydroxide Nanorods through Cationic Surface Functionalization

2017 ◽  
Vol 9 (26) ◽  
pp. 21697-21705 ◽  
Author(s):  
Bingbing Sun ◽  
Zhaoxia Ji ◽  
Yu-Pei Liao ◽  
Chong Hyun Chang ◽  
Xiang Wang ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Adjuvant Activity ◽  
Immune Adjuvant ◽  
Aluminum Oxyhydroxide

scholarly journals An immune adjuvant activity of mycolic acid-containing glycolipid, trehalose-2,3,6'-trimycolate, derived from Gordona aurantiaca.

1989 ◽  
Vol 44 (2) ◽  
pp. 533-539 ◽  
Author(s):  
Yoshikazu OHTSUBO ◽  
Masumi FURUKAWA ◽  
Yumiko FUJINOBU ◽  
Nobuko SUGIMOTO ◽  
Masatoshi IKUTOH ◽  
...  
Keyword(s):  
Mycolic Acid ◽  
Adjuvant Activity ◽  
Immune Adjuvant

The immune-adjuvant activity and the mechanism of resveratrol on pseudorabies virus vaccine in a mouse model

2019 ◽  
Vol 76 ◽  
pp. 105876 ◽  
Author(s):  
Meng Chen ◽  
Xiangxiu Chen ◽  
Xu Song ◽  
Abaidullah Muhammad ◽  
Renyong Jia ◽  
...  
Keyword(s):  
Mouse Model ◽  
Virus Vaccine ◽  
Pseudorabies Virus ◽  
Adjuvant Activity ◽  
Immune Adjuvant

scholarly journals A Heat-labile Enterotoxin B Subunit Mutant (LTB26) of Escherichia coli Enhances Mucosal Immune adjuvanticity via Increased BCR Activity

2020 ◽  
Author(s):  
Qinlin Shi ◽  
Qiujuan Wang ◽  
Sijing Chen ◽  
Sijie Gan ◽  
Tao Lin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Analysis Data ◽  
Binding Activity ◽  
Cell Mediated Immunity ◽  
Adjuvant Activity ◽  
B Subunit ◽  
Heat Labile ◽  
Enterotoxin B ◽  
Immune Adjuvant ◽  
Antigen Presenting

AbstractHeat-labile enterotoxin B subunit (LTB) of Escherichia coli is a potential mucosal immune adjuvant for its safety. However, the weaker adjuvant activity fails to meet the clinical requirement. Here, one of LTB mutant numbered LTB26 is constructed with enhanced mucosal immune adjuvanticity than that of LTB wild type (LTB). The transcriptome analysis data suggest that LTB26 enhances mucosal immune adjuvanticity via increased expression of BCR and MHC II+ molecular. Furthermore, LTB26 can promote both Th1 and Th2 cell mediated immunity via upregulated expression of IL-4 and IFN-γ. Flow cytometry analysis confirms that LTB26 significantly upregulates the activity of antigen presenting cells (DCs and mature macrophage) compared with LTB and LTB57 mutant. The result demonstrates that LTB26 is a potent mucosal immune adjuvant meeting clinical requirement. The GM1 ganglioside (GM1) binding activity of LTB57 is higher than that of LTB26; instead, the immune adjuvanticity of LTB57 is lower than that of LTB26. The result highlights that the immune adjuvanticity of LTB and its mutant are not positively associated with GM1 affinity, which upends decades understanding of the relationship of LTB adjuvanticity and GM1-binding affinity.

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