Modern dressing based on polymer microfibers with aluminum oxyhydroxide: properties and mechanism of wound healing

Objective: to investigate the structure of the new VitaVallis dressing and determine the mechanism of its wound healing effect. Materials and methods. To study the structure of the VitaVallis dressing, transmission and scanning electron microscopy methods were used. The course of the wound process was studied in 60 male mice of the Balb / c line. The healing of a wound defect under the influence of dressings was studied on the model of a “skin flap”. Morphometric evaluation of histological preparations was carried out by computer-aided graphical analysis of samples. Statistical processing of the results was carried out using the parametric (Student's test) and non-parametric (Wilcoxon's test) methods. For analysis, the program Statistica 6.0 was used. Results. The structure of the VitaVallis dressing is randomly spaced polymer fibers with a diameter of 1.0—5.0 microns, on the surface of which nanosheet structures of aluminum oxyhydroxide (AlOOH) are immobilized. In vivo experiments have shown that the use of VitaVallis dressing in the treatment of model wounds in mice promotes accelerated healing and leads to better epidermis organotypic differentiation and accelerates the maturation of granulation tissue. This effect is due to a combination of factors such as: reduction of inflammatory processes due to the removal and retention of wound exudate, including pathogenic microflora, stimulation of marginal epithelization, protection of the formed granulation tissue from drying out and acceleration of its maturation. Conclusion. Analysis of the structure and mechanism of the wound-healing action of the dressing VitaVallis suggests the effectiveness of its use in the local treatment of wounds.

Energy-saving technologies of technical service and processing of organic waste

Agricultural production in the Russian Federation is several times more energy-and material-intensive than in developed countries. (Research purpose) The research purpose is evaluation of the effectiveness of energy-saving technologies for technical maintenance of equipment using nanostructured aluminum oxyhydroxide and hydrothermal processing of agricultural waste in supercritical conditions. (Materials and methods) Nanostructured aluminum oxyhydroxide (boehmite) was produced by hydrothermal synthesis from aluminum powders. Tribological studies were carried out on a four-ball friction machine, a special device from WAGNER, on friction machines 2070 SMT-1M and MTU. Bench-in run was carried out on the D-240 engine and gearbox of a mobile drilling rig. The crushed solid waste of the agro-industrial complex was used as adsorbents for organic wastewater pollution. Their joint processing was carried out under hydrothermal supercritical conditions. (Results and discussion) It has been shown that nanostructure boehmite has antifriction, antiwear and extreme pressure properties. The possibility of its use as a product for running of a diesel engine has been found. The application of the boehmite in oils accelerates the running-in of a diesel engine, provides savings in material, labor and energy resources. For running-in of power transmission units, an additive containing bemite, surfactant, talc and kaolin reduced the running-in time of the drilling rig gearbox by 2.5 times. The article shows that the crushed plant waste of the agro-industrial complex, such as buckwheat husk, rice, and sunflower can be effectively used as adsorbents for the localization of pollution and wastewater treatment of agricultural enterprises. Subsequent processing of the adsorbent saturated with organic matter under hydrothermal supercritical conditions ensures the complete processing of organic substances to produce purified water and a high-enthalpy vapor-gas mixture or combustible gases, depending on the processing conditions. (Conclusions) Energy-saving technologies for the technical service of a diesel engine and transmission units can be based on the use of tribotechnical materials containing nanostructure boehmite. Technological solutions for energy-saving technologies for processing solid and liquid organic waste can consist in adsorption wastewater treatment followed by hydrothermal treatment in supercritical conditions.