Protein microbeadification to achieve highly concentrated protein formulation with reversible properties and in vivo pharmacokinetics after reconstitution

Present investigation comprises the study of ex-vivo skin flux and in-vivo pharmacokinetics of Thiocolchicoside (THC) from transdermal films. The films were fabricated by solvent casting technique employing combination of hydrophilic and hydrophobic polymers. A flux of 18.08 µg/cm2h and 13.37µg/cm2h was achieved for optimized formulations containing 1, 8-cineole and oleic acid respectively as permeation enhancers. The observed flux values were higher when compared to passive control (8.66 µg/cm2h). Highest skin permeation was observed when 1,8-cineole was used as chemical permeation enhancer and it considerably (2-2.5 fold) improved the THC transport across the rat skin. In vivo studies were performed in rabbits and samples were analysed by LC-MS-MS. The mean area under the curve (AUC) values of transdermal film showed about 2.35 times statistically significant (p<0.05) improvement in bioavailability when compared with the oral administration of THC solution. The developed transdermal therapeutic systems using chemical permeation enhancers were suitable for drugs like THC in effective management of muscular pain.

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Modified Release Biodegradable Polymeric Microspheres of Stavudine: Cell Viability, Cellular Uptake, Hemolysis Studies and In Vivo Pharmacokinetics

Current HIV Research ◽

10.2174/1570162x13666150624112345 ◽

2015 ◽

Vol 13 (6) ◽

pp. 503-516 ◽

Cited By ~ 1

Author(s):

Saurabh Srivastava ◽

Rajendra Kumar ◽

S.K. Arora ◽

V.R. Sinha

Keyword(s):

Cell Viability ◽

Cellular Uptake ◽

Modified Release ◽

Polymeric Microspheres ◽

In Vivo Pharmacokinetics

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Correction: A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images

Journal of Materials Chemistry B ◽

10.1039/d1tb90111g ◽

2021 ◽

Author(s):

Woonghee Lee ◽

Kondapa Naidu Bobba ◽

Jung Young Kim ◽

Hyun Park ◽

Abhinav Bhise ◽

...

Keyword(s):

High Contrast ◽

In Vivo Pharmacokinetics

Correction for ‘A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images’ by Woonghee Lee et al., J. Mater. Chem. B, 2021, 9, 2993–2997, DOI: 10.1039/D0TB02911D.

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In vivo pharmacokinetics in human volunteers: oral administered guar gum-based colon-targeted 5-fluorouracil tablets

European Journal of Pharmaceutical Sciences ◽

10.1016/s0928-0987(03)00139-8 ◽

2003 ◽

Vol 19 (5) ◽

pp. 355-362 ◽

Cited By ~ 59

Author(s):

Y.S.R Krishnaiah ◽

V Satyanarayana ◽

B Dinesh Kumar ◽

R.S Karthikeyan ◽

P Bhaskar

Keyword(s):

Guar Gum ◽

Human Volunteers ◽

In Vivo Pharmacokinetics

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Determination of the in vivo pharmacokinetics of palladium-bacteriopheophorbide (WST09) in EMT6 tumour-bearing Balb/c mice using graphite furnace atomic absorption spectroscopy

Photochemical & Photobiological Sciences ◽

10.1039/b403534h ◽

2004 ◽

Vol 3 (11-12) ◽

pp. 1006 ◽

Cited By ~ 25

Author(s):

Pierre Herv� Brun ◽

Jennifer L. DeGroot ◽

Eva F. Gudgin Dickson ◽

Mohsen Farahani ◽

Roy H. Pottier

Keyword(s):

Atomic Absorption ◽

Absorption Spectroscopy ◽

Atomic Absorption Spectroscopy ◽

Graphite Furnace ◽

Tumour Bearing ◽

Graphite Furnace Atomic Absorption ◽

In Vivo Pharmacokinetics

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In vitro AMPK activating effect and in vivo pharmacokinetics of mogroside V, a cucurbitane-type triterpenoid from Siraitia grosvenorii fruits

RSC Advances ◽

10.1039/c5ra23275a ◽

2016 ◽

Vol 6 (9) ◽

pp. 7034-7041 ◽

Cited By ~ 13

Author(s):

Zuliang Luo ◽

Feng Qiu ◽

Kailun Zhang ◽

Xijun Qin ◽

Yuhua Guo ◽

...

Keyword(s):

Siraitia Grosvenorii ◽

In Vivo Pharmacokinetics

The aim of this study was to explore the anti-diabetic effects of mogroside V (MV) and its aglycone mogrol (MO), both isolated from the fruits of Siraitia grosvenorii Swingle, and to investigate the pharmacokinetic behaviors of MV and its metabolite MO in rats.

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