Multilayered mucoadhesive hydrogel films based on Ocimum basilicum seed mucilage/thiolated alginate/dopamine-modified hyaluronic acid and PDA coating for sublingual administration of nystatin

2022 ◽  
Author(s):  
Masoomeh Sadat Hosseini ◽  
Babak Kamali ◽  
Mohammad Reza Nabid
Keyword(s):  
Hyaluronic Acid ◽  
Ocimum Basilicum ◽  
Sublingual Administration ◽  
Seed Mucilage ◽  
Hydrogel Films

scholarly journals Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimum basilicum gum

2012 ◽  
Vol 1 (9) ◽  
pp. 243-249 ◽  
Author(s):  
Sudheshnababu Sukhavasi ◽  
V. Sai Kishore
Keyword(s):  
Drug Delivery ◽  
Ocimum Basilicum ◽  
Angle Of Repose ◽  
Natural Polymers ◽  
Amlodipine Besylate ◽  
Disintegration Time ◽  
Fenugreek Seed ◽  
Wetting Time ◽  
Seed Mucilage

Fast dissolving/disintegrating tablets have received ever-increasing demand during the last decade, and the field has became a rapidly growing area in the pharmaceutical area. Particularly the fast dissolving drug delivery systems formulated with natural polymers have more demand because natural materials like gums and mucilages have been extensively used in the field of drug delivery for their easy availability, ease administration, non toxicity, non irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablets of amlodipine besylate tablets using Fenugreek seed mucilage and Ocimum basilicum gum as a natural superdisintegrating agents to achieve quick onset of action, is to increase the water uptake with in shortest wetting time and there by decrease the disintegration time of the tablets by simple and cost effective direct compression technique. Pre-compression parameters like angle of repose and post-compression parameters like wetting time, water absorption ratio, in-vitro disintegration and in-vitro dispersion time were studied. The hardness, friability and drug content of all the formulations were found to be within the limits. The best formulations FFGK5 & FOB5 have shown good disintegration time, hardness and friability. The best formulations were also found to be stable. Optimized formulation was subjected to stability studies as per ICH guidelines and it insignificant change in hardness, disintegration time and in vitro drug release.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11614 International Current Pharmaceutical Journal 2012, 1(9): 243-249 

scholarly journals Evaluation of Ocimum basilicum L. seed mucilage as rate controlling matrix for sustained release of propranolol HCl

2015 ◽  
Vol 1 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Majid Saeedi ◽  
Katayoun Morteza-Semnani ◽  
Jafar Akbari ◽  
Mohammad Hossein Bazargani ◽  
Gholamreza Amin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Ocimum Basilicum ◽  
Propranolol Hcl ◽  
Seed Mucilage

scholarly journals Extraction and Evaluation of Lipid Entrapment Ability of Ocimum basilicum L. Seed Mucilage

2021 ◽  
Vol 55 (3s) ◽  
pp. S790-S797
Author(s):  
Duy Nguyen-Le ◽  
Cao-Tri Nguyen ◽  
Quang Ton-That ◽  
Thuoc Linh Tran ◽  
Hieu Tran-Van
Keyword(s):  
Ocimum Basilicum ◽  
Seed Mucilage

Multilayered mucoadhesive hydrogel films based on thiolated hyaluronic acid and polyvinylalcohol for insulin delivery

2012 ◽  
Vol 8 (10) ◽  
pp. 3643-3651 ◽  
Author(s):  
J. Ding ◽  
R. He ◽  
G. Zhou ◽  
C. Tang ◽  
C. Yin
Keyword(s):  
Hyaluronic Acid ◽  
Insulin Delivery ◽  
Hydrogel Films

scholarly journals EXPLORING PROPERTIES OF SWEET BASIL SEED MUCILAGE IN DEVELOPMENT OF PHARMACEUTICAL SUSPENSIONS AND SURFACTANT-FREE STABLE EMULSIONS

2019 ◽  
Vol 11 (1) ◽  
pp. 124 ◽  
Author(s):  
Dhruti Avlani ◽  
Vaibhav Agarwal ◽  
Vansh Khattry ◽  
Gopa Roy Biswas ◽  
Sutapa Biswas Majee
Keyword(s):  
Stability Index ◽  
High Water ◽  
Ocimum Basilicum ◽  
Sweet Basil ◽  
Maximum Stability ◽  
Sedimentation Volume ◽  
Oil Emulsions ◽  
Form Development ◽  
Water Holding ◽  
Seed Mucilage

Objective: The objective of the investigation was to isolate mucilage from sweet basil seeds and explore its physicochemical properties for the development of pharmaceutical suspensions and surfactant-free stable emulsions.Methods: Possible applications of sweet basil seed mucilage in the pharmaceutical field for dosage form development are being explored. The physicochemical and functional properties of the mucilage from the seeds of the Ocimum basilicum L. (Sweet basil) have been investigated for stabilization of suspensions and emulsions. The following analyses were performed: FTIR spectroscopy, phytochemical tests, XRD, swelling and rheological studies.Results: The analyses showed that the mucilage is rich in glucose, mannose, and xylose. High swelling index values varying from 100±10 to 200±13%, high water-holding capacity of 97.5±2.4 g/g mucilage and reasonable oil holding capacity of the mucilage (13.2±1.3 g/g mucilage) makes it an ideal candidate for utilization as viscosifier and stabilizer of suspensions and surfactant-free emulsions. Adult and paediatric paracetamol suspension formulations with 1%w/v mucilage have exhibited flocculated nature and good stability owing to its high sedimentation volume(F= 0.85-0.98) and good redispersibility. Sunflower oil emulsions prepared with 0.25%w/v mucilage demonstrated emulsion stability index of 105.714 on 5th day and extremely low creaming rate of 0.0004 cm/h thus confirming maximum stability compared to emulsions developed with 0.3-0.5% w/v mucilage.Conclusion: The mucilage isolated from Ocimum basilicum L. seeds may be regarded as a functional biomaterial for pharmaceutical use to ensure quality and stability of liquid dosage forms.

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