Serum copper as a marker of inflammation in prediction of short term outcome in high risk patients with chronic heart failure

2006 ◽  
Vol 113 (2) ◽  
pp. E51-E53 ◽  
Author(s):  
F. Malek ◽  
E. Jiresova ◽  
A. Dohnalova ◽  
H. Koprivova ◽  
R Spacek
2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Victor Plat ◽  
Wessel Stam ◽  
Boukje Bootsma ◽  
Jennifer Straatman ◽  
Thomas Klausch ◽  
...  

Abstract   Transthoracic esophagectomy (TTE) for esophageal cancer facilitates mediastinal dissection, however it has a significant impact on cardiopulmonary status. High-risk patients may therefore be better candidates for transhiatal esophagectomy (THE) in order to prevent serious complications. This study addressed short-term outcome following TTE and THE in patients that are considered to have a higher risk of surgery-related morbidity. Methods This population-based study included patients who underwent a curative esophagectomy between 2011 and 2018, registered in the Dutch Upper GI Cancer Audit. The Charlson comorbidity index was used to assign patients to a low-risk (score ≤ 1) and high-risk group (score ≥ 2). Propensity score matching was applied to produce comparable groups between high-risk patients receiving TTE and THE. Primary endpoint was mortality (in-hospital/30-day mortality), secondary endpoints included morbidity and oncological outcomes. Additionally, a matched subgroup analysis was performed, including only cervical reconstructions. Results Of 5438 patients, 945 and 431 high-risk patients underwent TTE and THE respectively. After propensity score matching, mortality (6.3% vs 3.3%, P = 0.050), overall morbidity, Clavien-Dindo ≥3 complications, pulmonary complications, cardiac complications and re-interventions were significantly more observed after TTE compared to THE. A significantly higher mortality after TTE with a cervical reconstruction was found compared to THE (7.0% vs 2.2%, P = 0.020). Conclusion Patients with a high Charlson comorbidity index predispose for a complicated postoperative course after esophagectomy, this was more outspoken after TTE compared to THE. In daily practice these outcomes should be balanced with the lower lymph node yield, but comparable positive node count and radicality after THE.


2004 ◽  
Vol 10 (4) ◽  
pp. S106
Author(s):  
Marie A. Krousel-Wood ◽  
Mandeep R. Mehra ◽  
Ann S. Jannu ◽  
Xiao Z. Jiang ◽  
Richard N. Re

2018 ◽  
Vol 7 (33) ◽  
pp. 3665-3669
Author(s):  
Narasimha Pai D ◽  
Shiji Thomas ◽  
Syed Waleem Pasha ◽  
Padmanabha Kamath K ◽  
Kamath R. L ◽  
...  

2019 ◽  
Vol 25 (8) ◽  
pp. S109
Author(s):  
Victoria Thomas ◽  
Andrew Nagel ◽  
Rebecca Kafer ◽  
Cathy Schubert ◽  
Roopa Rao

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Olga A. Sawicki ◽  
Angelina Mueller ◽  
Renate Klaaßen-Mielke ◽  
Anastasiya Glushan ◽  
Ferdinand M. Gerlach ◽  
...  

AbstractIn 2004, Germany introduced a program based on voluntary contracting to strengthen the role of general practice care in the healthcare system. Key components include structured management of chronic diseases, coordinated access to secondary care, data-driven quality improvement, computerized clinical decision-support, and capitation-based reimbursement. Our aim was to determine the long-term effects of this program on the risk of hospitalization of specific categories of high-risk patients. Based on insurance claims data, we conducted a longitudinal observational study from 2011 to 2018 in Baden-Wuerttemberg, Germany. Patients were assigned to one or more of four open cohorts (in 2011, elderly, n = 575,363; diabetes mellitus, n = 163,709; chronic heart failure, n = 82,513; coronary heart disease, n = 125,758). Adjusted for key patient characteristics, logistic regression models were used to compare the hospitalization risk of the enrolled patients (intervention group) with patients receiving usual primary care (control group). At the start of the study and throughout long-term follow-up, enrolled patients in the four cohorts had a lower risk of all-cause hospitalization and ambulatory, care-sensitive hospitalization. Among patients with chronic heart failure and coronary heart disease, the program was associated with significantly reduced risk of cardiovascular-related hospitalizations across the eight observed years. The effect of the program also increased over time. Over the longer term, the results indicate that strengthening primary care could be associated with a substantial reduction in hospital utilization among high-risk patients.


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