Effects of intracoronary infusion of bone marrow-derived stem cells on pulmonary artery pressure and diastolic function after myocardial infarction

2010 ◽  
Vol 145 (3) ◽  
pp. 631-633 ◽  
Author(s):  
Johanna A. Miettinen ◽  
Riikka J. Salonen ◽  
Matti Niemelä ◽  
Kari Kervinen ◽  
Marjaana Säily ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Pulmonary Artery ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure ◽  
Intracoronary Infusion

scholarly journals Pulmonary hemodynamics and diastolic function of right ventricle at isometric exercises in children with chronic bronchopulmonary pathology

2011 ◽  
Vol 10 (3) ◽  
pp. 105-110
Author(s):  
L. I. Agapitov ◽  
Yu. M. Belozerov ◽  
Yu. L. Mizernitsky ◽  
S. E. Tsyplenkova
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Isometric Exercise ◽  
Healthy Children ◽  
Pulmonary Hemodynamics ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
The Right

We studied pulmonary hemodynamics and right ventricular diastolic function in 300 healthy children and 392 children with chronic bronchopulmonary pathology in an isometric exercise. Using echocardiography were determined systolic, diastolic, mean, pulmonary artery pressure, total pulmonary resistance, diastolic function of the right ventricle. Defined normal values of reactivity of pulmonary hemodynamics and diastolic function of the right ventricle in an isometric load. In patients with chronic bronchopulmonary pathology set higher increase of systolic, diastolic, mean, pulmonary artery pressure, decrease diastolic reserve the right ventricle compared to the control. The worst violations of pulmonary hemodynamics and diastolic function of the right ventricle during isometric load observed in patients with chronic Infectious-inflammatory and interstitial lung disease.

Impact of acute hypoxic pulmonary hypertension on LV diastolic function in healthy mountaineers at high altitude

2004 ◽  
Vol 286 (3) ◽  
pp. H856-H862 ◽  
Author(s):  
Yves Allemann ◽  
Martin Rotter ◽  
Damian Hutter ◽  
Ernst Lipp ◽  
Claudio Sartori ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
High Altitude ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Healthy Subjects ◽  
Artery Pressure ◽  
Altitude Exposure ◽  
Low Altitude ◽  
Lv Diastolic Function

In pulmonary hypertension right ventricular pressure overload leads to abnormal left ventricular (LV) diastolic function. Acute high-altitude exposure is associated with hypoxia-induced elevation of pulmonary artery pressure particularly in the setting of high-altitude pulmonary edema. Tissue Doppler imaging (TDI) allows assessment of LV diastolic function by direct measurements of myocardial velocities independently of cardiac preload. We hypothesized that in healthy mountaineers, hypoxia-induced pulmonary artery hypertension at high altitude is quantitatively related to LV diastolic function as assessed by conventional and TDI Doppler methods. Forty-one healthy subjects (30 men and 11 women; mean age 41 ± 12 yr) underwent transthoracic echocardiography at low altitude (550 m) and after a rapid ascent to high altitude (4,559 m). Measurements included the right ventricular to right atrial pressure gradient (ΔPRV-RA), transmitral early ( E) and late ( A) diastolic flow velocities and mitral annular early ( Em) and late ( Am) diastolic velocities obtained by TDI at four locations: septal, inferior, lateral, and anterior. At a high altitude, ΔPRV-RA increased from 16 ± 7to44 ± 15 mmHg ( P < 0.0001), whereas the transmitral E-to- A ratio ( E/ A ratio) was significantly lower (1.11 ± 0.27 vs. 1.41 ± 0.35; P < 0.0001) due to a significant increase of A from 52 ± 15 to 65 ± 16 cm/s ( P = 0.0001). ΔPRV-RA and transmitral E/ A ratio were inversely correlated ( r2 = 0.16; P = 0.0002) for the whole spectrum of measured values (low and high altitude). Diastolic mitral annular motion interrogation showed similar findings for spatially averaged (four locations) as well as for the inferior and septal locations: Am increased from low to high altitude (all P < 0.01); consequently, Em/ Am ratio was lower at high versus low altitude (all P < 0.01). These intraindividual changes were reflected interindividually by an inverse correlation between ΔPRV-RA and Em/ Am (all P < 0.006) and a positive association between ΔPRV-RA and Am (all P < 0.0009). In conclusion, high-altitude exposure led to a two- to threefold increase in pulmonary artery pressure in healthy mountaineers. This acute increase in pulmonary artery pressure led to a change in LV diastolic function that was directly correlated with the severity of pulmonary hypertension. However, in contrast to patients suffering from some form of cardiopulmonary disease and pulmonary hypertension, in these healthy subjects, overt LV diastolic dysfunction was not observed because it was prevented by augmented atrial contraction. We propose the new concept of compensated diastolic (dys)function.

scholarly journals The Effect of Respiratory Functions and Pulmonary Artery Pressure on Right and Left Ventricular Diastolic Function

2013 ◽  
Vol 16 (3) ◽  
pp. 205-213
Author(s):  
Şeref Alpsoy ◽  
Aydın Akyüz ◽  
Dursun Çayan Akkoyun ◽  
Mustafa Oran ◽  
Levent Cem Mutlu ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Ventricular Diastolic Function ◽  
Artery Pressure

Haemodynamic Effects of Intravenous Frusemide in Patients with Myocardial Infarction and Left Ventricular Failure

1974 ◽  
Vol 46 (2) ◽  
pp. 253-264 ◽  
Author(s):  
Anne E. Tattersfield ◽  
M. W. McNicol ◽  
R. W. Sillett
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Artery ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Pulmonary Artery Pressure ◽  
Left Ventricular ◽  
Left Ventricular Failure ◽  
Stroke Index ◽  
Ventricular Failure ◽  
Artery Pressure

1. Intravenous frusemide has been given to thirty-five patients with myocardial infarction and clinical signs of left ventricular failure. The haemodynamic changes following frusemide were then observed over the subsequent 6 h. 2. Frusemide produced a large diuresis, which was maximal during the first 2 h but fluid depletion was maintained at 24 h. The greatest diuresis occurred in patients with the highest stroke index. 3. All patients showed a fall in pulmonary artery pressure after frusemide. In patients with evidence of poor left ventricular function (low stroke index, high pulmonary artery pressure) this was associated with little change in stroke index. In patients with less severe impairment of left ventricular function there was an initial fall in stroke index at 1 and 2 h. 4. Six hours after frusemide there was a reduction in both pulmonary artery pressure and systemic arterial pressure; the latter correlated with the volume of the diuresis.

scholarly journals The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases

2020 ◽  
Vol 7 (1) ◽  
pp. 4
Author(s):  
Paolo Giovanardi ◽  
Enrico Tincani ◽  
Marco Maioli ◽  
Stefano Tondi
Keyword(s):  
Cardiovascular Diseases ◽  
Pulmonary Artery ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Left Ventricular ◽  
Functional Mitral Regurgitation ◽  
Artery Pressure ◽  
All Cause Mortality ◽  
Prognostic Importance ◽  
Lv Diastolic Function

The identification of predictors of major cardiovascular events (MACES) represents a big challenge, especially in early and stable cardiovascular diseases. This prospective study comparatively evaluated the prognostic importance of left ventricular (LV) and right ventricular (RV) systolic and diastolic function, pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) in a stable patient’s cohort with cardiovascular risk factors. The LV ejection fraction, mitral annular plane systolic excursion (MAPSE), tricuspid annular plane systolic excursion (TAPSE), functional mitral regurgitation (FMR), doppler tissue imaging of mitral and tricuspid annulus with systolic and diastolic peaks estimation, tricuspid regurgitation velocity (TRV), pulmonary velocity outflow time integral (PVTI), mean pulmonary artery pressure (MPAP) and PVR were estimated at enrollment. During the follow-up, MACES and all-cause mortality were recorded. 369 subjects with or without previous MACES were enrolled. Bivariate analysis revealed LVEF, TAPSE, MPAP, TRV, PVR, LV diastolic function, and FMR were associated with the endpoints. When computing the influence of covariates to the primary endpoint (all-cause mortality and MACES) through Cox analysis, only LV diastolic function and TAPSE entered the final model; for the secondary endpoint (MACES) only TAPSE entered. TAPSE was able to predict MACES and all-cause mortality in early and stable cardiovascular diseases. The use of TAPSE should be implemented.

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