Concomitant Repair For Mild Aortic Insufficiency And Implantation Of Left Ventricle Mechanical Support

Aortic valve regurgitation in patients undergoing LVAD implantation is a significant complication which occurs in up to 10% of patients in the INTERMACS database. Patients who have aortic valve regurgitation at the time of implant have been handled by several methods, including aortic valve leaflets approximation, to aortic valve replacement or even valve closure. We report a case where we used HAART Ring to repair a regurgitant aortic valve during LAVD implant for destination therapy.

The Effect of Intake Valve Timing on Spark-Ignition Engine Performances Fueled by Natural Gas at Low Power

To reduce the greenhouse effect, it is important to reduce not only carbon dioxide but also methane emissions. Methane gas can be not only a fossil fuel (natural gas) but also a renewable energy source when it is extracted from biomass. After biogas has been purified, its properties become closer to those of natural gas or methane. Natural gas is an alternative energy source that can be used for spark-ignition engines, but its physicochemical properties are different from those of gasoline, and the spark-ignition engine control parameters need to be adjusted. This article presents the results of a study that considers a spark-ignition engine operating at different speeds (2000 rpm, 2500 rpm, and 3000 rpm) and the regulation of the timing of intake valve closure when the throttle is partially open (15%), allowing the engine to maintain the stoichiometric air–fuel mixture and constant spark timing. Studies have shown a reduction in engine break torque when petrol was replaced by natural gas, but break thermal efficiency has increased and specific emissions of pollutants (NOx, HC, CO2 (g/kWh)) have decreased. The analysis of the combustion process by the AVL BOOST program revealed different results when the engine ran on gasoline as opposed to when it ran on natural gas when the timing of intake valve closure changed. The volumetric efficiency of the engine and the speed of the combustion process, which are significant for engine performance due to the different properties of gasoline and natural gas fuels, can be partially offset by adjusting the spark timing and timing of intake valve closure. The effect of intake valve timing on engine fueled by natural gas more noticeable at lower engine speeds when the engine load is low.

Quantifying preload alterations using a sensitive chest-mounted accelerometer

Seismocardiography (SCG) is a technology where the chest wall vibrations from the beating heart are measured using a highly sensitive accelerometer. SCG offers continuous measurement of cardiac function and potential applications include remote monitoring, diagnostic assessments, prognostic health checks and biventricular pacemaker optimization. Aim In the current study we examined how changes in preload influence SCG time intervals, by acute saline infusion. Methods We included twenty-six subjects, sixteen subjects with cardiac disease such as hypertrophic cardiomyopathy, dilated cardiomyopathy, aortic valve disease or ischemic heart disease (age 45.8±17.7 years and 93% male) and ten subjects without known cardiac conditions (age 42.1±14.4 years and 70% male). SCG was recorded from the xiphoid process using a custom-made sensor before and after acute infusion saline (median 2.0 L). The SCG signals were sampled with 5000 samples per second in 60 seconds, the individual heartbeats were identified using a dedicated segmentation algorithm and an average SCG beat was computed and used for the data analysis. Using a recently proposed nomenclature the following SCG fiducial points was identified: Es which coinciding with mitral valve closure, Gs which to some degree coincides with aortic opening, Bd coinciding with aortic valve closure and Fd coinciding with mitral valve opening [1]. The Es-Gs time interval was used as a measure of isovolumetric contraction time (IVCT), the Gs-Bd time interval was used as an estimate of ejection time (ET) and the Bd-Fd time interval as an estimate of isovolumetric relaxation time (IVRT). Paired t-test was used to test for significant response after infusion, while a two sample t-test was used to test for a significant difference in the observed response in subjects with or with our cardiac disease. Results For two subjects SCG after infusion was not obtained thus, twenty-four subjects were included in the final data analysis. In the whole group, acute saline infusion shortened the IVRT (Bd-Fd) from 91.0±15.3 ms to 82.7±15.3 ms (p=0.004) and prolonged the ET (Gs-Bd) from 329.4±35 ms to 343.4±33 ms (p<0.001). There was no significant change in IVCT (Es-Gs) which was 39.5±15.1 ms at baseline and 38.1±14.9 ms post-infusion (p=0.88). There was no significant difference in response between subjects with or without cardiac disease. Conclusion Increase in preload shortened the SCG time intervals related to the isovolumetric relaxation period and prolonged the period related to ejection time. SCG time intervals capture changes in preload, which demonstrates that the SCG is a potential modality for quantification of cardiac dynamics. Funding Acknowledgement Type of funding sources: None.

The Effects of Temperature and Salinity Stressors on the Survival, Condition and Valve Closure of the Manila Clam, Venerupis philippinarum in a Holding Facility

This article investigates the response of the Manila clam Venerupis philippinarum to possible temperature and salinity changes in a holding facility. First, clams are exposed to four temperatures for 15 days. Valve closure and survival of clams exposed to seawater at 18 °C are higher than those exposed to seawater at 24 °C. Second, clams are exposed to six salinities for 15 days. Survival of clams exposed to two salinity fluctuation conditions (24–30 and 27–24 psu) is lower than that of clams exposed to constant 30 psu conditions. Valve closures of clams exposed to constant low salinity conditions (24 psu) and two salinity fluctuation conditions (24–30 and 27–24 psu) are higher than those exposed to constant 30 psu conditions. Lastly, clams are exposed to two different temperatures and three different salinities conditions for eight days. Valve closure and survival decreased significantly under the combination of 24 °C and 18 psu. These results suggest that an increase in temperature or a wider range of salinity fluctuations are detrimental to the survival of the Manila clam. The synergistic effect of temperature and salinity stressors may decrease the survival period of clams compared to the effect of a single stressor.

The Effects of Temperature and Salinity Stressors on the Survival, Condition, and Valve Closure of the Manila Clam, Venerupis philippinarum in a Holding Facility

We investigated the response of the Manila clam Venerupis philippinarum to possible temperature and salinity changes in a holding facility. First, clams were exposed to four temperatures for 15 days. Valve closure and survival of clams exposed to seawater at 18℃ were higher than that of those exposed to seawater at 24℃. Second, clams were exposed to six salinities for 15 days. Survival of clams exposed to two salinity fluctuation conditions (24–30 and 27–24 psu) was lower than that of clams exposed to constant 30 psu conditions. Valve closures of clams exposed to constant low salinity conditions (24 psu) and two salinity fluctuation conditions (24–30 and 27–24 psu) were higher than of those exposed to constant 30 psu conditions. Lastly, clams were exposed to two different temperatures and three different salinities conditions for 8 days. Valve closure and survival decreased significantly under the combination of 24℃ and 18 psu. These results suggest that an increase in temperature or a wider range of salinity fluctuations are detrimental to the survival of the Manila clam. The synergistic effect of temperature and salinity stressors may decrease the survival period of clams compared to the effect of a single stressor.

Simulation of Non-Return Valve Closure in a Thixomolding Process Utilizing a Magnesium Alloy

Simulation of Non-Return Valve Closure in a Thixomolding Process Utilizing a Magnesium Alloy

Simulation of Non-Return Valve Closure in a Thixomolding Process Utilizing a Magnesium Alloy

Simulation of Non-Return Valve Closure in a Thixomolding Process Utilizing a Magnesium Alloy

Dynamic interaction between valve-closure water hammer wave and centrifugal pump

Water hammer is a principal cause of pipeline and equipment failure in pumping systems. The numerical method and experiments are used to investigate the dynamic interaction between the valve-closure water hammer wave and pump, to study the pressure variation and fluid-induced force on the pump components. The impeller-volute interaction and impeller position are taken into consideration. Results show that the valve-closure water hammer wave generates a substantial fluid-induced force on the pump and leads to a pressure surge in the pipeline. Meanwhile, the impeller-volute interaction also causes pressure and force variation in the pipeline and pump. The force amplitude caused by this factor in the axial direction is similar to that caused by the water hammer wave but is much smaller in the radial direction. The different interaction position of the water hammer wave on the blades can weaken the force, by 13.11% and 13.18% for the impeller and volute when the blades are under the most optimal position, respectively.