Low level non-invasive vagus nerve stimulation: A novel feasible therapeutic approach for atrial fibrillation

2015 ◽  
Vol 182 ◽  
pp. 189-190 ◽  
Author(s):  
Shuyan Li ◽  
Xiaoya Zhou ◽  
Lilei Yu ◽  
Hong Jiang
Keyword(s):  
Atrial Fibrillation ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Therapeutic Approach ◽  
Low Level ◽  
Non Invasive

Low-Level Vagus Nerve Stimulation Suppresses Post-Operative Atrial Fibrillation and Inflammation

2017 ◽  
Vol 3 (9) ◽  
pp. 929-938 ◽  
Author(s):  
Stavros Stavrakis ◽  
Mary Beth Humphrey ◽  
Benjamin Scherlag ◽  
Omer Iftikhar ◽  
Purvi Parwani ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level ◽  
Post Operative Atrial Fibrillation

scholarly journals Low-Level Transcutaneous Electrical Vagus Nerve Stimulation Suppresses Atrial Fibrillation

2015 ◽  
Vol 65 (9) ◽  
pp. 867-875 ◽  
Author(s):  
Stavros Stavrakis ◽  
Mary Beth Humphrey ◽  
Benjamin J. Scherlag ◽  
Yanqing Hu ◽  
Warren M. Jackman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level

scholarly journals Low-Level Vagus Nerve Stimulation Reverses Obstructive Sleep Apnea-Related Atrial Fibrillation by Ameliorating Sympathetic Hyperactivity and Atrial Myocyte Injury

2021 ◽  
Vol 11 ◽  
Author(s):  
Yankai Guo ◽  
Jiasuoer Xiaokereti ◽  
Qingjun Meng ◽  
Guiqiu Cao ◽  
Huaxin Sun ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Sympathetic Hyperactivity ◽  
Low Level ◽  
Obstructive Sleep ◽  
Atrial Myocyte

Background: Previous studies have proved that low-level vagus nerve stimulation (LLVS) could suppress acute obstructive sleep apnea (OSA), which is associated with atrial fibrillation (AF).Objective: This study investigates the underlying electrophysiological, neural, and cardiomyocyte injury mechanisms on acute OSA-induced AF, examining whether LLVS can attenuate or reverse this remodeling.Methods and Results: Eighteen mongrel dogs received endotracheal intubation under general anesthesia and were randomly divided into three groups: the OSA group (simulated OSA with clamping of the trachea cannula at the end of expiration for 2min followed ventilation 8min, lasting 6h, n=6), the OSA+LLVS group (simulated OSA plus LLVS, n=6), and a control group (sham clamping the trachea cannula without stimulation, n=6). In the OSA+LLVS group, the atrial effective refractory period was significantly lengthened while the sinus node recovery time and AF duration decreased after the 4th hour, and the expression level of Cx40 and Cx43 was significantly increased compared to the OSA group. Norepinephrine, TH, and ChAT were significantly decreased in the OSA+LLVS group compared with the OSA group. Mitochondrial swelling, cardiomyocyte apoptosis, and glycogen deposition, along with a higher concentration of TNF-α, IL-6 were observed in the OSA group, and the LLVS inhibited the structural remodeling and expression of inflammatory cytokines.Conclusion: LLVS decreased the inducibility of AF partly by ameliorating sympathetic hyperactivity and atrial myocyte injury after acute OSA-induced AF.

scholarly journals Non-invasive vagus nerve stimulation reduced neuron-derived IL-1β and neuroinflammation in acute ischemic rat brain

2021 ◽  
Author(s):  
Lisa Y Yang ◽  
Kiran Bhaskar ◽  
Jeffrey Thompson ◽  
Kelsey Duval ◽  
Michel Torbey ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Rat Brain ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Non Invasive

scholarly journals Non-invasive vagus nerve stimulation boosts mood recovery after effort exertion

2021 ◽  
pp. 1-11
Author(s):  
Magdalena Ferstl ◽  
Vanessa Teckentrup ◽  
Wy Ming Lin ◽  
Franziska Kräutlein ◽  
Anne Kühnel ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Positive Mood ◽  
Credible Interval ◽  
Cognitive Effort ◽  
Mood States ◽  
Non Invasive ◽  
Lower Baseline ◽  
Open Question

Abstract Background Mood plays an important role in our life which is illustrated by the disruptive impact of aberrant mood states in depression. Although vagus nerve stimulation (VNS) has been shown to improve symptoms of depression, the exact mechanism is still elusive, and it is an open question whether non-invasive VNS could be used to swiftly and robustly improve mood. Methods Here, we investigated the effect of left- and right-sided transcutaneous auricular VNS (taVNS) v. a sham control condition on mood after the exertion of physical and cognitive effort in 82 healthy participants (randomized cross-over design) using linear mixed-effects and hierarchical Bayesian analyses of mood ratings. Results We found that 90 min of either left-sided or right-sided taVNS improved positive mood [b = 5.11, 95% credible interval, CI (1.39–9.01), 9.6% improvement relative to the mood intercept, BF10 = 7.69, pLME = 0.017], yet only during the post-stimulation phase. Moreover, lower baseline scores of positive mood were associated with greater taVNS-induced improvements in motivation [r = −0.42, 95% CI (−0.58 to −0.21), BF10 = 249]. Conclusions We conclude that taVNS boosts mood after a prolonged period of effort exertion with concurrent stimulation and that acute motivational effects of taVNS are partly dependent on initial mood states. Collectively, our results show that taVNS may help quickly improve affect after a mood challenge, potentially by modulating interoceptive signals contributing to the reappraisal of effortful behavior. This suggests that taVNS could be a useful add-on to current behavioral therapies.

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