Neutrophil gelatinase-associated lipocalin predicts myocardial dysfunction and mortality in severe sepsis and septic shock

2017 ◽  
Vol 227 ◽  
pp. 589-594 ◽  
Author(s):  
Biao Wang ◽  
Gang Chen ◽  
Jia Li ◽  
Yuanying Zeng ◽  
Yunfu Wu ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Myocardial Dysfunction ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Sepsis And Septic Shock ◽  
Neutrophil Gelatinase

scholarly journals Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic Shock

2012 ◽  
Vol 87 (7) ◽  
pp. 620-628 ◽  
Author(s):  
Juan N. Pulido ◽  
Bekele Afessa ◽  
Mitsuru Masaki ◽  
Toshinori Yuasa ◽  
Shane Gillespie ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Myocardial Dysfunction ◽  
Clinical Spectrum ◽  
Sepsis And Septic Shock

scholarly journals Serum Neutrophil Gelatinase-Associated Lipocalin in Infants and Children with Sepsis-Related Conditions with or without Acute Renal Dysfunction

2016 ◽  
Vol 10 ◽  
pp. CMPed.S39452 ◽  
Author(s):  
Mohammed Farouk M. Afify ◽  
Sheren Esam Maher ◽  
Nora Mohamed Ibrahim ◽  
Waleed Mahamoud Abd El-Hamied
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Kidney Injury ◽  
Control Group ◽  
Characteristic Analysis ◽  
Acute Renal Dysfunction ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Group I ◽  
Neutrophil Gelatinase ◽  
Apparently Healthy

Purpose To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury (AKI) in sepsis-related conditions and its predictive and prognostic values. Patients and Methods This study included 65 patients, who were clinically evaluated for sepsis, severe sepsis, or septic shock, and 20 apparently healthy served as controls. Patients were divided into two groups: Group I (AKI-sepsis): 65 newly admitted patients diagnosed as sepsis, who were further divided into three subgroups according to the severity: systemic inflammatory response syndrome, severe sepsis, and septic shock, and Group II (control group): 20 apparently healthy subjects matched for age and sex, serum creatinine and serum NGAL concentrations were estimated initially within 24 hours of admission and after 72 hours of admission in all patients and control groups. Results Serum NGAL increased significantly with increasing severity of renal impairment. Receiver-operating characteristic analysis suggested that serum NGAL cutoff value of 40 ng/mL within the first 24 hours of admission is highly specific and sensitive for predicting AKI, with sensitivity of 90.9% and specificity of 75.8%. Conclusion We concluded that early measurement of serum NGAL level in sepsis can serve as a clinically useful marker for early prediction of AKI and for grading of its severity.

Myocardial Dysfunction in Severe Sepsis and Septic Shock

CHEST Journal ◽  
2015 ◽  
Vol 148 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Giora Landesberg ◽  
Phillip D. Levin ◽  
Dan Gilon ◽  
Sergey Goodman ◽  
Milena Georgieva ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Myocardial Dysfunction ◽  
Sepsis And Septic Shock

scholarly journals Frequency and clinical spectrum of myocardial dysfunction in severe sepsis and septic shock

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P392
Author(s):  
JN Pulido ◽  
T Yuasa ◽  
M Masaki ◽  
S Gillespie ◽  
V Herasevich ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Myocardial Dysfunction ◽  
Clinical Spectrum ◽  
Sepsis And Septic Shock

scholarly journals Echocardiographic Assessment of Left Ventricular Systolic and Diastolic Functions in Dogs with Severe Sepsis and Septic Shock; Longitudinal Study

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2011
Author(s):  
Mehmet Ege Ince ◽  
Kursad Turgut ◽  
Amir Naseri
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Longitudinal Study ◽  
Myocardial Dysfunction ◽  
Left Ventricular ◽  
Control Group ◽  
Prospective Longitudinal Study ◽  
Diastolic Velocity ◽  
Sepsis And Septic Shock ◽  
Prospective Longitudinal

The purpose of this study was to monitor left ventricular systolic dysfunction (LVSD) and diastolic dysfunction (LVDD) using transthoracic echocardiography (TTE) in dogs with severe sepsis and septic shock (SS/SS). A prospective longitudinal study using 23 dogs with SS/SS (experimental group) and 20 healthy dogs (control group) were carried out. All the clinical, laboratory and cardiologic examinations for the experimental dogs were performed at admission, 6 and 24 h after the start of treatment and on the day of discharge. LVSD was described as LV ejection fraction (LVEF) < 50%. LVDD was determined when the septal mitral annulus early diastolic velocity (LVEm) was <8 cm/s. LVSD and LVDD were present in 3 and 16 dogs with SS/SS, respectively, with both types of dysfunction present in 2 of the dogs. Although all the dogs with LVSD survived, 8 dogs with LVDD did not. The survival period was significantly shorter in dogs with an LVEm < 8 cm/s (1.3 ± 1.4 days). In conclusion, LVDD, rather than LVSD, was a common cardiovascular abnormality in the septic dogs, and this may be a negative prognostic factor. TTE is a useful tool for the identifying and monitoring of myocardial dysfunction in the dogs with SS/SS.

Effect of fluid bolus triggers and their combination on fluid responsiveness in optimization phase of severe sepsis and septic shock resuscitation

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 27-32
Author(s):  
Bien Le ◽  
Dai Huynh ◽  
Mai Tuan ◽  
Minh Phan ◽  
Thao Pham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Fluid Responsiveness ◽  
Statistical Significance ◽  
Venous Pressure ◽  
Fluid Bolus ◽  
Low Blood Pressure ◽  
Low Central Venous Pressure ◽  
Sepsis And Septic Shock

Objectives: to evaluate the fluid responsiveness according to fluid bolus triggers and their combination in severe sepsis and septic shock. Design: observational study. Patients and Methods: patients with severe sepsis and septic shock who already received fluid after rescue phase of resuscitation. Fluid bolus (FB) was prescribed upon perceived hypovolemic manifestations: low central venous pressure (CVP), low blood pressure, tachycardia, low urine output (UOP), hyperlactatemia. FB was performed by Ringer lactate 500 ml/30 min and responsiveness was defined by increasing in stroke volume (SV) ≥15%. Results: 84 patients were enrolled, among them 30 responded to FB (35.7%). Demographic and hemodynamic profile before fluid bolus were similar between responders and non-responders, except CVP was lower in responders (7.3 ± 3.4 mmHg vs 9.2 ± 3.6 mmHg) (p 0.018). Fluid response in low CVP, low blood pressure, tachycardia, low UOP, hyperlactatemia were 48.6%, 47.4%, 38.5%, 37.0%, 36.8% making the odd ratio (OR) of these triggers were 2.81 (1.09-7.27), 1.60 (0.54-4.78), 1.89 (0.58-6.18), 1.15 (0.41-3.27) and 1.27 (0.46-3.53) respectively. Although CVP < 8 mmHg had a higher response rate, the association was not consistent at lower cut-offs. The combination of these triggers appeared to raise fluid response but did not reach statistical significance: 26.7% (1 trigger), 31.0% (2 triggers), 35.7% (3 triggers), 55.6% (4 triggers), 100% (5 triggers). Conclusions: fluid responsiveness was low in optimization phase of resuscitation. No fluid bolus trigger was superior to the others in term of providing a higher responsiveness, their combination did not improve fluid responsiveness as well.

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