High sensitivity cardiac troponin T and systemic right ventricular function in adults with congenitally corrected transposition of the great arteries

2017 ◽  
Vol 241 ◽  
pp. 168-172 ◽  
Author(s):  
Ewa Kowalik ◽  
Anna Klisiewicz ◽  
Justyna Rybicka ◽  
Elżbieta K. Biernacka ◽  
Piotr Hoffman
Keyword(s):  
Right Ventricular ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

High-Sensitive Cardiac Troponin T and Systemic Right Ventricular Area Predict Outcomes in Adults With Congenitally Corrected Transposition

2018 ◽  
Vol 34 (9) ◽  
pp. 1129-1136 ◽  
Author(s):  
Ewa Kowalik ◽  
Anna Klisiewicz ◽  
Mirosław Kowalski ◽  
Justyna Rybicka ◽  
Rafał Baranowski ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

scholarly journals Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis

2015 ◽  
Vol 55 (4) ◽  
pp. 203
Author(s):  
Nusarintowati Ramadhina ◽  
Rubiana Sukardi ◽  
Najib Advani ◽  
Rinawati Rohsiswatmo ◽  
Sukman T. Putra ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Function ◽  
Preterm Infants ◽  
Neonatal Sepsis ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Ctnt Level ◽  
Rv Function

Background Hemodynamic instability in sepsis, especially in the neonatal population, is one of the leading causes of death in hospitalized infants. The major contribution for heart dysfunction in neonatal sepsis is the myocardial dysfunction that leads to decreasing of ventricular function. The combination of echocardiography and laboratory findings help us to understand the ventricular condition in preterm infants with sepsis.Objective To assess for a correlation between ventricular function and serum high-sensitivity cardiac troponin T (hs-cTnT) level in preterm infants with neonatal sepsis.Methods We prospectively studied 30 preterm infants with neonatal sepsis who were admitted to the neonatal intensive care unit (NICU) of Cipto Mangunkusumo Hospital from June 1 – August 31, 2013. The ventricular functions were measured using 2-dimensional echocardiography. The parameters of right ventricular (RV) function assessment were tricuspid annular plane systolic excursion (TAPSE) and RV myocardial performance index (MPI). For left ventricular (LV) performance, we assessed ejection fraction (EF), fractional shortening (FS), and LV-MPI. Serum hs-cTnT was measured and considered to be a marker of myocardial injury.Results Subjects had a mean gestational age of 31.5 (SD 2.18) weeks and mean birth weight of 1,525 (SD 437.5) g. The mean LV function measured by MPI was 0.281 (SD 0.075); mean EF was 72.5 (SD 5.09)%; and mean FS was 38.3 (SD 4.29)%. The RV function measured by TAPSE was mean 6.85 (SD 0.94) and that measured by MPI was median 0.255 (range 0.17-0.59). Serum hs-cTnT level was significantly higher in non-survivors than in survivors [282.08 (SD 77.81) pg/mL vs. 97.75 (24.2-142.2) pg/mL, respectively P =0.023]. There were moderate correlations between LV-MPI and hs-cTnT concentration (r=0.577; P=0.001), as well as between RV-MPI and hs-cTnT concentration (r=0.502; P=0.005). The positive correlation between LV and RV-MPI in neonatal sepsis was strong (r=0.77; P <0.001).Conclusion Left and right ventricular MPI show positive correlations with hs-cTnT levels. Serum hs-cTnT is significantly higher in non survivors. As such, this marker may have prognostic value for neonatal sepsis patients.

In congenitally corrected transposition of great arteries following Fontan surgery, a left ventricle with suprasystemic systolic and high end-diastolic pressures paradoxically preserves right ventricular and tricuspid valve function

2019 ◽  
Vol 29 (12) ◽  
pp. 1522-1523
Author(s):  
Santosh Wadile ◽  
Ejaz A. Sheriff ◽  
Kothandam Sivakumar
Keyword(s):  
Left Ventricle ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Left Ventricular ◽  
Transposition Of Great Arteries ◽  
Valve Function ◽  
Fontan Surgery ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

AbstractSystemic right ventricular function in congenitally corrected transposition depends on septal geometry. Suprasystemic left ventricular systolic pressures and high end-diastolic pressures after Fontan surgery paradoxically preserve right ventricular function.

High-Sensitivity Cardiac Troponin T Reflects Left Ventricular Function of Non-ACS Patients

2012 ◽  
Vol 18 (10) ◽  
pp. S168
Author(s):  
Hiroaki Otsuka ◽  
Kouta Okabe ◽  
Keiji Yamada ◽  
Takashi Fujiwara ◽  
Takashi Miki ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Cardiac Troponin T

Right ventricular function and ventricular perfusion defects in adults with congenitally corrected transposition: correlation of echocardiography and nuclear medicine

2004 ◽  
Vol 14 (2) ◽  
pp. 174-181 ◽  
Author(s):  
Nilda Espinola-Zavaleta ◽  
Erick Alexanderson ◽  
Fause Attié ◽  
Luis Muñoz Castellanos ◽  
Roy Dueñas ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Tricuspid Regurgitation ◽  
Right Ventricular Function ◽  
Predictive Value ◽  
Contrast Echocardiography ◽  
Perfusion Defects ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

We undertook our study in order to evaluate right ventricular function and perfusion by conventional and contrast echocardiography in adults with congenitally corrected transposition who had not undergone cardiac surgery, comparing the echocardiographic findings with those obtained using equilibrium radionuclide ventriculography and gated single-photon emission computed tomography with Technetiumc-99 m sestamibi.We discovered severe tricuspid regurgitation in 8 patients (61%). Right ventricular ejection fraction, as calculated by nuclear medicine, had a correlation of 0.67 (p = 0.059) with area fractional shortening and 0.84 (p = 0.01) with ejection fraction calculated by the method depending on descent of the tricuspid ring. All patients with severe tricuspid regurgitation also had right ventricular dysfunction. Of these 8 patients, 7 had persistent perfusion defects, while 6 also had ischemic perfusion defects.Echo contrast had a high sensitivity, at 91%, and also specificity and positive predictive value, both at 100%, for persistent defects, and a negative predictive value of 66% compared to methods depending on nuclear medicine. The sensitivity of contrast echocardiography for detection of ischemic defects was 66%, the specificity 100%, the positive predictive value 100%, and the negative predictive value 77% compared to the methods involving nuclear medicine.The method depending on descent of the tricuspid ring had the highest correlation with equilibrium radionuclide ventriculography in evaluation of right ventricular function in patients with congenitally corrected transposition.We conclude that contrast echocardiography is extremely valuable when assessing right ventricular myocardial perfusion, having high sensitivity and specificity for detecting persistent defects, although sensitivity was less for detection of ischemic defects than that of gated single-photon emission computed tomography with Technetium-99 m Sestamibi.Persistent and ischemic perfusion defects, together with chronic volume overload from tricuspid regurgitation, are the determining factors of right ventricular dysfunction.

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