Long-term treatment with ivabradine over 12 months in patients with chronic heart failure in clinical practice: Effect on symptoms, quality of life and hospitalizations

Unlike many other forms of inflammatory arthritis, the crystal arthropathies are routinely diagnosed and managed in primary care. Gout, in particular, is relatively commonplace and rates of other types of crystal-related arthritis are predicted to increase. These are, therefore, conditions that GPs and trainees will regularly encounter during routine practice. While the clinical features and pathophysiology of gout and pseudo-gout are well described, the long-term treatment goals and options of management are often less well understood, and opportunities to assess for associated co-morbidities can easily be missed. GPs can be central in optimising management by promptly and appropriately addressing acute symptoms, preventing recurrent attacks, minimising disability and work absences, reducing cardiovascular risk factors, improving general health and enhancing quality of life.

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SUPPORTING DEVICES IN THE TREATMENT OF CHRONIC HEART FAILURE IN ELDERLY AND OLD PATIENTS

Pharmacy Formulas ◽

10.17816/phf41944 ◽

2020 ◽

Vol 2 (3) ◽

pp. 40-57

Author(s):

Gennadiy Hubulava ◽

Kirill L. Kozlov ◽

Andrey N. Bogomolov ◽

Aleksey Volkov ◽

Viktor N. Fedorets ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Clinical Practice ◽

Chronic Heart Failure ◽

Severe Heart Failure ◽

Circulatory Support ◽

Old Patients ◽

Western Countries ◽

Surgical Methods

Chronic heart failure (CHF) is a widespread disease associated with high rates of disability and mortality, as well as a decrease in the quality of life. Moreover, the vast majority of patients are elderly and senile. Modern surgical methods of treating heart failure are able to increase the duration and quality of life of such patients, however, the need far exceeds the volume of this care, and some highly effective methods common in Western countries are still not used in Russian clinical practice. Elderly age is a risk factor for the development of senile asthenia (frailty) and concomitant pathology. Large abdominal surgery is often contraindicated for patients with signs of senile asthenia, and the method of choice in patients with severe heart failure is the implantation of devices for long-term mechanical circulatory support (LT-MCS). After implantation of LT-MCS, a regression of signs of senile asthenia may be observed. The topic of an integrated approach to non-drug treatment of heart failure in elderly and senile patients in Russia has not been studied enough. In particular, the implantation of LT-MCS is not used in Russian clinical practice, while in many Western countries for many years it has been the main and most effective treatment for severe heart failure. Systematization of the available up-to-date information on this topic could help increase the duration and quality of life of patients with severe heart failure.

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Concerns and Quality of Life of Cancer Survivors Across the Survivorship Trajectory: A Singapore Perspective

10.21203/rs.2.14780/v1 ◽

2019 ◽

Author(s):

Gek Phin Chua ◽

Quan Sing Ng ◽

Hiang Khoon Tan ◽

Whee Sze Ong

Keyword(s):

Quality Of Life ◽

Cancer Survivors ◽

Cancer Treatment ◽

Cancer Survivorship ◽

Recurrence Risk ◽

Term Treatment ◽

Fear Of Recurrence ◽

Long Term Treatment

Abstract Background The aim of this study is to determine the main concerns of survivors at various stages of the cancer survivorship of the cancer survivorship trajectory and to assess whether these concerns have any effect on their quality of life (QOL). The overall goal was to use the insights from the study to guide practice on patient care. Methods A cross-sectional survey of 1107 cancer survivors diagnosed with colorectal, breast, lung, gynaecological, prostate or liver cancers from a cancer centre in Singapore. Eligible patients self-completed a questionnaire adapted from the Mayo Clinic Cancer Centre’s Cancer Survivors Survey of Needs. Results The top 5 concerns among all survivors were cancer treatment and recurrence risk (51%), followed by long-term treatment effects (49%), fear of recurrence (47%), financial concerns (37%) and fatigue (37%). Cancer treatment and recurrence risk, long-term treatment effects and fear of recurrence were amongst the top concerns across the survivorship trajectory. Mean QOL was 7.3 on a scale of 0 – 10. Completed treatment patients had higher QOL score than the newly diagnosed and on treatment patients and the patients dealing with recurrence or second cancer patients. Predictors for QOL included the economic status and housing type of patients and whether patients were concerned with pain and fatigue Conclusion This study confirms that cancer survivors in Singapore face multiple challenges and had various concerns at various stages of cancer survivorship, some of which negatively affect their QOL It is critical to design patient care delivery that appropriately address the various concerns of cancer survivors in order for them to cope and improve their QOL.

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Effects of long-term treatment with Dienogest on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain

Journal of Pain Research ◽

10.2147/jpr.s207599 ◽

2019 ◽

Vol Volume 12 ◽

pp. 2371-2378 ◽

Cited By ~ 13

Author(s):

Salvatore Caruso ◽

Marco Iraci ◽

Stefano Cianci ◽

Salvatore Giovanni Vitale ◽

Valentina Fava ◽

...

Keyword(s):

Quality Of Life ◽

Sexual Function ◽

Pelvic Pain ◽

Term Treatment ◽

Long Term Treatment

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Changes in vascular responsiveness of rats with chronic heart failure and effects of long-term treatment with trandolapril.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)36770-8 ◽

1996 ◽

Vol 71 ◽

pp. 133

Author(s):

Hiroko Toyoshima ◽

Yoshihisa Nasa ◽

Yumi Kohsaka ◽

Yoko Isayama ◽

Fuminari Yamaguchi ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Term Treatment ◽

Long Term Treatment ◽

Vascular Responsiveness

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Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer

European Journal of Cancer ◽

10.1016/j.ejca.2004.03.025 ◽

2004 ◽

Vol 40 (11) ◽

pp. 1704-1712 ◽

Cited By ~ 119

Author(s):

I.J Diel ◽

J.-J Body ◽

M.R Lichinitser ◽

E.D Kreuser ◽

W Dornoff ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Bone Disease ◽

Term Treatment ◽

Metastatic Bone Disease ◽

Long Term Treatment

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What Is a Clinically Relevant Improvement in Quality of Life in Adults With ADHD?

Journal of Attention Disorders ◽

10.1177/1087054715580395 ◽

2015 ◽

Vol 23 (1) ◽

pp. 65-75

Author(s):

Yoko Tanaka ◽

Meryl Brod ◽

Jeannine R. Lane ◽

Himanshu Upadhyaya

Keyword(s):

Quality Of Life ◽

Adult Adhd ◽

Minimal Clinically Important Difference ◽

Term Treatment ◽

Short Term ◽

Treatment Groups ◽

Clinically Important Difference ◽

Long Term Treatment

Objective: To estimate a minimal clinically important difference (MCID) on the adult ADHD Quality of Life (AAQoL) scale. Method: The MCID was determined from data from short-term ( N = 537) and long-term ( N = 440), placebo-controlled atomoxetine trials in adults with ADHD. For the anchor-based approach, change in clinician-rated Clinical Global Impressions–ADHD–Severity (CGI-ADHD-S) scores was used to derive MCID. For the distribution-based approach, baseline-to-endpoint mean ( SD) changes in AAQoL scores corresponding to 0.5 SD were computed. Results: The MCID was similar (approximately 8-point difference) between the short-term and the long-term treatment groups when either the anchor-based or distribution-based approach was used. Conclusion: These results suggest that approximately 8 points in the change from baseline on the AAQoL is a MCID.

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