scholarly journals Cardiac pericyte is promising target for ischemic heart diseases: Role of Notch3

2017 ◽  
Vol 246 ◽  
pp. 57 ◽  
Author(s):  
Jian-Xiong Chen ◽  
Sean T. Chen ◽  
Yong-Kang Tao
Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S18-S19 ◽  
Author(s):  
Francesco Forastiere ◽  
Pasi Aalto ◽  
Tom Bellander ◽  
Niklas Berglind ◽  
Daniela d’Ippoliti ◽  
...  

2021 ◽  
Vol 8 (4) ◽  
pp. 198
Author(s):  
AsmaaH Abdelhady ◽  
MohamedS Abdullah ◽  
ElsayedE Elsayed ◽  
AhmedS Ibrahim ◽  
MahmoudA Soliman

2017 ◽  
Vol 45 (07) ◽  
pp. 1401-1419 ◽  
Author(s):  
Dawei Wang ◽  
Weiqing Yu ◽  
Yuntao Liu ◽  
Guofu Zhong ◽  
Zhen Zhao ◽  
...  

Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective functions, such as inhibiting atherosclerosis progression and reducing cell death during the ischemic phase. However, recent studies have suggested its dual roles in myocardial ischemia/reperfusion (MIR) injury. Excessive autophagy may play a deleterious role in cardiac function, due to overwhelming clearance of cellular constituents and proteins. Hence modulation of autophagy to increase cardiomyocyte survival and improve cardiac function is meaningful for the treatment of IHD. Chinese herbal medicine, including extractive compounds and patented drugs, has shown its potential role in treating IHD by addressing autophagy-related mechanisms. This review summarizes the updated knowledge on the molecular basis and modulatory role of autophagy in IHD and the recent progress of Chinese herbal medicine in its treatment.


2013 ◽  
Vol 29 (5) ◽  
pp. 629-637 ◽  
Author(s):  
Ola Sayed Ali ◽  
Hanan Muhammad Abdelgawad ◽  
Makram Sayed Mohammed ◽  
Rehab Refaat El-Awady

1976 ◽  
Vol 25 (1) ◽  
pp. 271-275 ◽  
Author(s):  
Ulf de Faire

From January 1971 to March 1973 all twin pairs in the Swedish Twin Registry below the age of 70, who became death-discordant, were continuously recorded. A total of 205 (78%) of the surviving cotwins were examined with respect to different manifestations of ischemic heart diseases (IHD) and several “environmental” and “biometric” risk factors. Among the death-discordant pairs, the cause of death was IHD in 57 pairs and other than IHD in 148 pairs. Analyses revealed that the prevalence rate of myocardial infarction, angina pectoris, pathologic Q-wave, and ST depressions in connection with exercise, were significantly higher among the surviving cotwins whose partners had died from IHD than those whose partners had died from other causes. The same trends were seen for most of the risk factors measured both singly and in combination, although not very pronounced. The results indicate a substantial genetic influence in the development of IHD. The genetic influence is possibly transmitted not only through some of the risk factors measured, but also through other factors, still unknown.


2015 ◽  
Vol 115 (7) ◽  
pp. 48B-58B ◽  
Author(s):  
A. Mark Richards ◽  
Salvatore Di Somma ◽  
Thomas Mueller

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