Ischemic Heart Disease in Death Discordant Twins - A Study on 205 Male and Female Pairs with Special Reference to Hereditary Factors

From January 1971 to March 1973 all twin pairs in the Swedish Twin Registry below the age of 70, who became death-discordant, were continuously recorded. A total of 205 (78%) of the surviving cotwins were examined with respect to different manifestations of ischemic heart diseases (IHD) and several “environmental” and “biometric” risk factors. Among the death-discordant pairs, the cause of death was IHD in 57 pairs and other than IHD in 148 pairs. Analyses revealed that the prevalence rate of myocardial infarction, angina pectoris, pathologic Q-wave, and ST depressions in connection with exercise, were significantly higher among the surviving cotwins whose partners had died from IHD than those whose partners had died from other causes. The same trends were seen for most of the risk factors measured both singly and in combination, although not very pronounced. The results indicate a substantial genetic influence in the development of IHD. The genetic influence is possibly transmitted not only through some of the risk factors measured, but also through other factors, still unknown.

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Risk Factors Associated with Ischemic Heart Diseases in Different Age Groups Patients of Tertiary Care Hospitals of Peshawar

Journal of Gandhara Medical and Dental Science ◽

10.37762/jgmds.1-2.64 ◽

2015 ◽

Vol 1 (2) ◽

pp. 3-9

Author(s):

Riaz Gul ◽

Sumaira Naz

Keyword(s):

Risk Factors ◽

Heart Diseases ◽

Tertiary Care ◽

Age Groups ◽

Ischemic Heart ◽

P Value ◽

Age Group ◽

Ischemic Heart Diseases ◽

Sedentary Life ◽

Tertiary Care Hospitals

Objectives:To determine different risk factors associated with ischemic heart diseases in different age group patients of tertiary care hospitals of Peshawar.Methodology:A cross sectional study conducted on 350 patients of different age groups presented with ischemic heart diseases in tertiary care hospitals of Peshawar. Study was conducted for duration of 3 months from December 2013 to February 2014. Non probability convenient sampling technique was used. Sample size was calculated using standard sample size calculator. Semi structured questionnaire was used as data collection tool. Patient’s record and investigations were used as adding tools. Standard definition was made for ischemic heart disease. Different modifiable and non-modifiable factors were assessed and were analyzed using SPSS version 16.Results:This study contains 350 patients in which female patients were 133(38%) and male were 217(62%).The mean age was 57.23±11.36 years. The age of the patients ranges from 22 to 80 years. The frequencies of risk factors were stress (73.1%) followed by hypertension (65.7%), sedentary life style (59.4%), family history (57.1%), smoking (50.6%), over weight and obese (39.1%), below normal HDL (30.3%), high LDL (29.1%), hypertriglyceridemia (28%), hypercholesterolemia (23.7%). 64.3% patients were presenting with acute IHD and 35.7% were with chronic IHD. Stress, HTN, DM and sedentary life style were found to be significantly associated with male gender (p- value <0.05). Age was divided into two groups, <45 years and >45 years. Stress, HTN, DM and hypercholesterolemia had a significant association with >45 years of age group. (P-value <0.05).Conclusion:Stress, HTN, DM, sedentary life styles were the major risk factors. And they were found to be more in male gender and in equal to more than 45 years of age group.

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A study on the clinical profile and risk factors of ischemic heart disease in women

Medpusle International Journal of Medicine ◽

10.26611/102119310 ◽

2021 ◽

Vol 19 (3) ◽

pp. 130-132

Author(s):

Sarath Kumar Reddy B ◽

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Chest Pain ◽

Ischemic Heart Disease ◽

Stable Angina ◽

Heart Diseases ◽

Chronic Stable Angina ◽

Clinical Profile ◽

Ischemic Heart ◽

Ischemic Heart Diseases

Background: Ischemic heart disease (IHD) is one of the principle causes of morbidity and of mortality in women1. Ischemic heart disease may manifest clinically as either chronic stable angina or acute coronary syndrome2 (ACS). Traditional risk factors (hypertension, diabetes, etc.) contribute to the development of IHD in both women and men. Some risk factors are unique to women (e.g., pregnancy-related complications, menopause), which cause increased mortality in women Aim: To study the risk factors and clinical profile of ischemic heart disease in women. Materials And Methods: Hospital-based prospective, cross-sectional study done in 50 patients with ischemic heart disease. Patients with a history of Chest pain suggestive of ischemic heart diseases and Electrocardiogram and cardiac biomarkers suggestive of ischemic heart disease were included in the study. Results: Maximum incidence of ischemic heart diseases is seen in the 6th decade. Mean age is 58.92 + 2.8years. 64%of the patients presented with chest pain, and 36% patients presented without any chest pain. After chest pain, the most common symptom was palpitations, seen in 56% patients, followed by sweating (44%). 30% presented to the medical facility within 3hours. 88% were diagnosed with acute coronary syndrome, and 12% were diagnosed with chronic stable angina. Women specific risk factors include the pregnancy-related complications seen in 10% patients, menopause attained in 86% patients, PCOS seen in 08% patients, use of oral contraceptive pills noticed in 08% patients, Other risk factors identified were hypothyroidism in 16% patients, connective tissue disorders like rheumatoid arthritis seen in 12% of the patients. Conclusion: Awareness regarding atypical symptoms as well as other symptoms of IHD should be created among women to avoid delayed complications. Simple lifestyle modifications like physical activity, diet modifications, etc., will reduce the number of women at risk for IHD.

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Risk Factors for Isolated Left Main Coronary Artery Disease

Ibrahim Cardiac Medical Journal ◽

10.3329/icmj.v1i1.7649 ◽

1970 ◽

Vol 1 (1) ◽

pp. 17-21

Author(s):

Syed Dawood Md Taimur ◽

M Maksumul Haq ◽

Tamzeed Ahmed ◽

Md Rezaul Karim ◽

MA Rashid ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Left Main Coronary Artery ◽

Heart Diseases ◽

Ischemic Heart ◽

Coronary Angiogram ◽

Left Main ◽

Ischemic Heart Diseases ◽

Traditional Risk Factors ◽

Artery Disease

Background & objective: Left main coronary artery (LMCA) stenosis (defined as 50 or > 50 percent narrowing of luminal diameter) usually has a bad prognosis unless revascularization done. Isolated left main coronary artery (ILMCA) disease is a rare clinical entity. Although it carries a grave prognosis, its etiology is not well-understood. Determining risk factors for ILMCA disease might be promising in the preventive strategy of ischemic heart diseases. The aim of this study was to determine the demographic and traditional risk factors for left main coronary artery disease. Methods: This cross-sectional study was done on patients who underwent coronary angiogram (CAG) at Ibrahim Cardiac Hospital & Research Institute from February 2005 to June 2009. Total number of procedures done in Cath Lab was 7103. Of them 6708(94%) cases underwent CAG. Only 18 of them (0.27%) had isolated left main lesion and were included as cases. Patients who did not have ILMCA were taken as controls. The number of controls selected was 8 times the number of cases (n = 144). Of them 3 were excluded because of incomplete data leaving 141 controls finally. Fifty or > 50% stenosis in the left main was considered as significant stenosis. Major demographic and clinical information of patients were collected from the database of the Institute and were compared between the case and control groups. Results: Of the 18 subjects who had ILMCA disease 44.4% exhibited stable angina, 27.8% had ACS. One third of these patients had normal ECG, ST-T changes in another one third of the patients and 11% had previous MI. 16.7% patients had wall motion abnormality in echocardiogram. Only 4 out of these 18 patients had ETT done before CAG and all were found positive. Patients with ILMCA disease were comparatively old (> 50 years) than the patients without ILMCA disease (p = 0.448). Females were more prevalent in the case group (27.8%) than that in the control group (22.2%) (p = 0.854). There was no significant difference between patients with or without ILMCA disease in terms of traditional risk factors for ischemic heart diseases like hypertension, diabetes, smoking habit, dyslipidemia and family history of ischemic heart diseases (p > 0.05). Conclusion: Isolated and significant LMCA disease is an unusual angiographic finding and presents most commonly as stable angina. A female preponderance is usually observed. The prevalence of atherosclerotic risk factors of these patients is similar to that of the general population undergoing coronary angiogram. Key words: Isolated left main disease; risk factors; coronary angiogram; significant lesion. Ibrahim Card Med J 2011; 1(1):17-21

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Análise epidemiológica das internações hospitalares por doença isquêmica do coração no Piauí entre 2017 e 2020

Archives of Health ◽

10.46919/archv2n4esp-006 ◽

2021 ◽

Vol 2 (4) ◽

pp. 776-779

Author(s):

Milena Viana Freire ◽

Mariana de Sousa Meneses Carvalho ◽

Aureliano Machado De Oliveira

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Hospital Admissions ◽

Heart Diseases ◽

Ischemic Heart ◽

Ischemic Heart Diseases

RESUMO As doenças isquêmicas do coração (DIC) estão entre as principais causas de internações hospitalares no Piauí. Os índices são mais expressivos quanto maior a exposição aos fatores de risco cardiovasculares, o que ressalta a importância da adoção de hábitos mais saudáveis. ABSTRACT Ischemic heart diseases (IHD) are among the main causes of hospital admissions in Piauí. The higher the exposure to cardiovascular risk factors, the more expressive the indices are, which highlights the importance of adopting healthier habits.

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