scholarly journals Ten-year experience with fungal peritonitis in peritoneal dialysis patients: antifungal susceptibility patterns in a North-American center

2012 ◽  
Vol 16 (1) ◽  
pp. e41-e43 ◽  
Author(s):  
Jasmin Levallois ◽  
Annie-Claire Nadeau-Fredette ◽  
Annie-Claude Labbé ◽  
Michel Laverdière ◽  
Denis Ouimet ◽  
...  
2015 ◽  
Vol 35 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Annie-Claire Nadeau-Fredette ◽  
Joanne M Bargman

IntroductionPeritonitis remains a common complication of peritoneal dialysis (PD). Although representing only 1 – 12% of overall peritonitis in dialysis patients, fungal peritonitis (FP) is associated with serious complications, including technique failure and death. Only scarce data have been published regarding FP outcomes in modern cohorts in North America. In this study we evaluated the rates, characteristics and outcomes of FP in a major North American PD center.MethodsWe conducted a retrospective cohort study including all fungal peritonitis episodes among peritoneal dialysis patients followed in a large PD center between January 2000 and February 2013. Our pre-specified end-points included rates of FP, characteristics, outcomes and determinants of death.ResultsThirty-six episodes of FP were identified during the follow-up period (one episode per 671 patient-months), representing 4.5% of the total peritonitis events. Patients’ mean age and peritoneal dialysis vintage were 61.3 ± 15.5 and 2.9 (1.5 – 4.8) years, respectively. Of the 36 episodes of FP, seven (19%) resulted in death and 17 (47%) led to technique failure with permanent transfer to hemodialysis. Surprisingly, PD was eventually resumed in 33% of cases with a median delay of 15 weeks (interquartile range 8 – 23) between FP and catheter reinsertion. In a univariable analysis, a higher Charlson comorbidity index (Odds ratio [OR] 3.25 per unit increase, 95% confidence interval [CI] 1.23 – 8.58) and PD fluid white blood cell (WBC) count greater than 3,000/mm3at presentation (OR 6.56, 95% CI 1.05 – 40.95) predicted death.ConclusionWhile fungal peritonitis is still associated with a high frequency of death and technique failure, one-third of our patients eventually returned to PD. Patients with a high burden of comorbidities appear at higher risk of death. We postulate that the high mortality associated with FP is partially related to the severity of comorbidity among patients with F P, rather than the infection per se. Importantly, PD can be resumed in a significant proportion of cases.


2009 ◽  
Vol 27 (1) ◽  
pp. 59-61
Author(s):  
E Indhumathi ◽  
V Chandrasekaran ◽  
D Jagadeswaran ◽  
M Varadarajan ◽  
G Abraham ◽  
...  

2016 ◽  
Vol 25 ◽  
Author(s):  
Tuğba Yılmaz ◽  
Orçun Altunören ◽  
Didem Atay ◽  
Safa Ganidağlı ◽  
Elif İnanç ◽  
...  

Mycoses ◽  
2007 ◽  
Vol 50 (1) ◽  
pp. 79-81 ◽  
Author(s):  
Nuno Guimarães Rosa ◽  
Sónia Silva ◽  
José António Lopes ◽  
Patrícia Branco ◽  
Edgar de Almeida ◽  
...  

2009 ◽  
Vol 76 (6) ◽  
pp. 622-628 ◽  
Author(s):  
Rhianna Miles ◽  
Carmel M. Hawley ◽  
Stephen P. McDonald ◽  
Fiona G. Brown ◽  
Johan B. Rosman ◽  
...  

2010 ◽  
Vol 36 (4) ◽  
pp. 186-190 ◽  
Author(s):  
Rumeyza Kazancioglu ◽  
Gulbahar Kirikci ◽  
Muserref Albaz ◽  
Rukiye Dolgun ◽  
Serpil Ekiz

Author(s):  
Emanuelle Barbara Dias Tomaz ◽  
Plínio Trabasso ◽  
Gabriela Jorge Trigo Alves ◽  
Rodrigo Bueno de Oliveira

Peritonitis is one of the most common complications of the population with chronic kidney disease on peritoneal dialysis. The most frequent etiological agents are bacteria and fungi, the latter being responsible for 2 to 5% of the total cases of this type of infection. Fungal peritonitis is severe and its occurrence requires immediate removal of the catheter and transfer of renal replacement therapy for hemodialysis. The present study aimed to retrospectively study the risk factors and clinical outcomes of patients at the Centro Integrado de Nefrologia (CIN) of the Hospital das Clínicas da UNICAMP, who presented bacterial or fungal peritonitis, comparing them to peritoneal dialysis patients who did not present peritonitis.


Sign in / Sign up

Export Citation Format

Share Document