scholarly journals Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection

2012 ◽  
Vol 16 (3) ◽  
pp. e204-e208 ◽  
Author(s):  
Anastasia Antonopoulou ◽  
Fotini Baziaka ◽  
Thomas Tsaganos ◽  
Maria Raftogiannis ◽  
Pantelis Koutoukas ◽  
...  
Keyword(s):  
Influenza A ◽  
Tumor Necrosis ◽  
H1n1 Virus ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Factor Gene ◽  
Influenza A H1n1 ◽  
Necrosis Factor ◽  
H1n1 Virus Infection

scholarly journals Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1224
Author(s):  
Marco Antonio Ponce-Gallegos ◽  
Aseneth Ruiz-Celis ◽  
Enrique Ambrocio-Ortiz ◽  
Gloria Pérez-Rubio ◽  
Alejandra Ramírez-Venegas ◽  
...  
Keyword(s):  
Influenza A ◽  
Host Susceptibility ◽  
Nucleotide Polymorphisms ◽  
H1n1 Infection ◽  
Single Nucleotide ◽  
Mexican Mestizo ◽  
Influenza A H1n1 ◽  
Mexican Mestizo Population ◽  
Reduced Risk

(1) Background: The influenza A/H1N1 pdm09 virus rapidly spread throughout the world. Despite the inflammatory and virus-degradation pathways described in the pathogenesis of influenza A virus (IAV) infection, little is known about the role of the single nucleotide polymorphisms (SNPs) in the genes involved in the processing and antigenic presentation-related mechanisms. (2) Methods: In this case-control study, we evaluated 17 SNPs in five genes (TAP1, TAP2, TAPBP, PSMB8, and PSMB9). One hundred and twenty-eight patients with influenza A/H1N1 infection (INF-P) and 111 healthy contacts (HC) were included; all of them are Mexican mestizo. (3) Results: In allele and genotype comparison, the rs241433/C allele (TAP2), as well as AG haplotype (rs3763365 and rs4148882), are associated with reduced risk for influenza A/H1N1 infection (p < 0.05). On the other hand, the rs2071888G allele (TAPBP) and GG haplotype (rs3763365 and rs9276810) are associated with a higher risk for influenza A/H1N1 infection. In addition, after adjustment for covariates, the association to a reduced risk for influenza A/H1N1 infection remains with rs241433/C allele (p < 0.0001, OR = 0.24, 95% CI = 0.13–0.43), and the association with TAPBP is also maintained with the G allele (p = 0.0095, OR = 1.89, 95% CI = 1.17–3.06) and GG genotype models (p < 0.05, OR = 2.18, 95% CI = 1.27–3.74). (4) Conclusion: The rs241433/C allele and AC genotype (TAP2) and the AG haplotype are associated with a reduced risk for influenza A/H1N1 infection. In addition, the rs2071888/G allele and GG genotype (TAPBP) and the GG haplotype are associated with a higher risk for developing influenza A/H1N1 infection in a Mexican mestizo population.

scholarly journals Tumor necrosis factor (TNF)-α gene +489 polymorphisms: association with psoriatic arthritis

2013 ◽  
Vol 86 (1) ◽  
Author(s):  
G. Murdaca ◽  
F. Puppo
Keyword(s):  
Psoriatic Arthritis ◽  
Tumor Necrosis Factor ◽  
Single Nucleotide Polymorphisms ◽  
Tumor Necrosis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Tnf Α ◽  
The Difference ◽  
Necrosis Factor

Objective of this work was to investigate the role of single nucleotide polymorphisms (SNPs) at position +489 of the tumor necrosis factor (TNF)-α gene in generic susceptibility and severity of psoriatic arthritis (PsA). Fifty-seven Caucasian PsA patients diagnosed according to CASPAR criteria and 155 healthy matched controls were studied. PASI score, DAS28 and Disability INdex HAQ were calculated. Genomic DNA was extracted from peripheral blood samples and SNPs +489 G&gt;A (rs 80267959) were amplified by PCR. The SNP +489 genotype was significantly associated with PsA susceptibility (p=0.0136) and severity of clinical and laboratory parameters (p values ranging from 0.016 to 2.908 x 10-12). The difference in severity was accounted for by the difference between the AA and GA genotypes with respect to the GG genotype. These findings suggest that TNF-α gene polymorphisms may influence PsA susceptibility and severity. Psoriatics arthritis (PsA) is a complex immunemediated disease that results from the interplay between multiple genetic and environmental factor [1]. Although the pathogenesis of PsA remains elusive, there is evidence that genetic factors may contribute to the etiology of the disease [2]. Is has been estimated that at least one third of the genetic contribution to PsA resides in the major histocompatibility complex (MHC) region [2]. The tumor necrosis factor (TNF)-α gene, which is located in the short arm of chromosome 6 in the MHC class III region between the HLA-B and HLA-DR genes, has been proposed as a major candidate gene in PsA [3]. This hypothesis is supported by studies which have found high serum, synovial fluid and synovial membrane TNF-α levels in patients with PsA [4,5]. Several single nucleotide polymorphisms (PNPs) have been identified in the TNF-α gene promoter [6]. In particular, two common polymorphisms, namely G to A substitutions at positions -238 and -308 have been studied in patients with PsA. However, association studies of these two TNF-α polymorphisms and genetic susceptibility to PsA have lead to conflicting results [7-12]. Previous studies have indicated the potential role of the SNP at +489 position in the first intron of the TNF-α gene in the susceptibility to some rheumatic autoimmune diseases like rheumatoid arthritis [13], systemic lupus erythematosus [14] and systemic sclerosis [15]. However, to our present knowledge, studies on the association of +489 polymorphism with PsA susceptibility and response to TNF-α inhibitors are not reported in the literature. Is this study we investigated the role of SNPs at +489 within the TNF-α gene in PsA susceptibility and severity.

scholarly journals Origins of the new influenza A(H1N1) virus: time to take action

2009 ◽  
Vol 14 (22) ◽  
Author(s):  
G M Nava ◽  
M S Attene-Ramos ◽  
J K Ang ◽  
M Escorcia
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
Phylogenetic Analyses ◽  
Protein Sequences ◽  
Interspecies Transmission ◽  
Genetic Evolution ◽  
Protein Homology ◽  
Influenza A H1n1 ◽  
Insight Into

To gain insight into the possible origins of the 2009 outbreak of new influenza A(H1N1), we performed two independent analyses of genetic evolution of the new influenza A(H1N1) virus. Firstly, protein homology analyses of more than 400 sequences revealed that this virus most likely evolved from recent swine viruses. Secondly, phylogenetic analyses of 5,214 protein sequences of influenza A(H1N1) viruses (avian, swine and human) circulating in North America for the last two decades (from 1989 to 2009) indicated that the new influenza A(H1N1) virus possesses a distinctive evolutionary trait (genetic distinctness). This appears to be a particular characteristic in pig-human interspecies transmission of influenza A. Thus these analyses contribute to the evidence of the role of pig populations as “mixing vessels” for influenza A(H1N1) viruses.

scholarly journals A Pregnant Case with Severe Influenza A (H1N1) Virus Infection-Related ARDS

2011 ◽  
Vol 8 (2) ◽  
Author(s):  
Turgut Teke ◽  
Ümmiye Duran ◽  
Emin Maden ◽  
Kazım Gezginç ◽  
Mehmet D Yavşan ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A ◽  
H1n1 Virus ◽  
Severe Influenza ◽  
Influenza A H1n1 ◽  
H1n1 Virus Infection
Sign in / Sign up

Export Citation Format

Share Document