Diagnostic yield of Xpert MTB/RIF on Contrast-enhanced Ultrasound Guided Pleural Biopsy Specimens for Pleural Tuberculosis

Based on the option that ultrasound-guided core needle biopsy (US-CNB) of the enhanced portion of anterior mediastinal masses (AMMs) identified by contrast-enhanced ultrasound (CEUS) would harvest viable tissue and benefit the histological diagnoses, a retrospective study was performed to elucidate the correlation between the prebiopsy CEUS and diagnostic yield of AMMs and found that CEUS potentially improved the diagnostic yield of AMMs compared with conventional US with a significant increase in the cellularity of samples. Furthermore, the marginal blood flow signals and absence of necrosis can predict the diagnostic yield of AMM. It was concluded that US-CNB of the viable part of AMMs, as verified by CEUS, was able to harvest sufficient tissue with more cellularity that could be used for ancillary studies and improve the diagnostic yield. And CEUS was recommended to those patients with AMMs undergoing repeated US-CNB, with the absence of marginal blood signals or presence of necrosis.

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Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01583-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wenwen Sun ◽

Yiming Zhou ◽

Cong Yang ◽

Zhengwei Dong ◽

ZheMin Zhang ◽

...

Keyword(s):

Prospective Study ◽

Diagnostic Yield ◽

Contrast Enhanced Ultrasound ◽

Clinical Trial Registry ◽

Pleural Biopsy ◽

Serious Adverse Events ◽

Guided Biopsy ◽

Contrast Enhanced ◽

Diagnostic Biopsy ◽

A Prospective Study

Abstract Objective To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of radiologically determined pleural based lesions. Method A prospective study was conducted on patients with radiologically determined pleural based lesions. Patients who met the inclusion criteria received pleural biopsy guided by CEUS to obtain specimens, followed by histomathological and microbiological examinations. After treatment and follow-up, surgical thoracoscopy was performed on cases with undefinite diagnosis. Result A total of 460 patients were finally included. CEUS showed internal necrosis in 72.17% cases and obvious peripheral vessels in 55.43% cases, both of which were significantly higher than the conventional ultrasound imaged (p < 0.05). The diagnostic accuracy through CEUS guided biopsy sampling was 98.91% (455/460). The microbiological diagnostic yield achieved 71.88% (225/313) in infectious lesions. In 330 cases combined pleural effusion, CEUS guided biopsy increased the diagnostic yield from 60.30% (199 /330) to 98.36% (325 /330) in all cases (p < 0.05), from 15.56% (14/90) to 94.44% (85/90) in malignant lesions (p < 0.01) and from 77.08% (185/240) to 100% (240/240) in infectious lesions (p < 0.05). No serious adverse events occurred. Conclusion CEUS guided biopsy provides a minimally invasive, effective and safe diagnostic biopsy method for pleural lesions. Clinical Trials Registration: Chinese Clinical Trial Registry ChiCTR2000029749 (ChiCTR, www.chictr.org.cn).

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Clinical performance of Xpert MTB/RIF on contrast-enhanced ultrasound-guided core biopsy specimens for rapid diagnosis of superficial tuberculous lymphadenitis in high TB burden settings

Infection ◽

10.1007/s15010-021-01578-w ◽

2021 ◽

Author(s):

Wenwen Sun ◽

Jin Gu ◽

Ke Bi ◽

Yi Zhang ◽

Meng-jun Shen ◽

...

Keyword(s):

Core Biopsy ◽

Clinical Performance ◽

Rapid Diagnosis ◽

Tuberculous Lymphadenitis ◽

Contrast Enhanced Ultrasound ◽

Ultrasound Guided ◽

Biopsy Specimens ◽

Contrast Enhanced

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Contrast-Enhanced Ultrasound Guided Pleural Biopsy Improves Diagnostic Confidence in Multidisciplinary Diagnosis of Pleural Lesions: A 3-year Prospective Study

10.21203/rs.3.rs-424800/v1 ◽

2021 ◽

Author(s):

Wenwen Sun ◽

Yiming Zhou ◽

Cong Yang ◽

Zhengwei Dong ◽

ZheMin Zhang ◽

...

Keyword(s):

Prospective Study ◽

Diagnostic Yield ◽

Contrast Enhanced Ultrasound ◽

Clinical Trial Registry ◽

Pleural Biopsy ◽

Serious Adverse Events ◽

Guided Biopsy ◽

Contrast Enhanced ◽

Diagnostic Biopsy ◽

A Prospective Study

Abstract Objective: To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of pleural lesions.Method: A prospective study was conducted on patients with undiagnosed pleural lesions. Patients who met the inclusion criteria received pleural biopsy guided by CEUS to obtain specimens, followed by histomathological and etiological examinations. After treatment and follow-up, surgical thoracoscopy was performed for cases of undefinite diagnosis.Result: A total of 460 patients were finally included. CEUS showed internal necrosis in 72.17% cases and peripheral obvious vessels 55.43% cases , both of which were significantly higher than the conventional ultrasound imaged (P 0.00). The diagnostic accuracy through CEUS guided biopsy sampling was 98.91% (455/460). The etiological diagnostic yield achieved 88.82% (278/313) in infectious lesions. In 330 cases combined pleural effusion, CEUS guided biopsy increased the diagnostic yield from 60.30 % (199 /330 ) to 98.36 % (325 /330) in all cases (P 0.00）, from 15.56 % (14/90) to 94.44% (85/90) in malignant lesions ( P 0.00）and from 77.08 %（185/240）to 100%（240/240, P 0.00) in infectious lesions. No serious adverse events occurred. Conclusion: CEUS guided biopsy provides a minimally invasive、 effective and safe diagnostic biopsy method for pleural lesions.Clinical Trials Registration: Chinese Clinical Trial Registry ChiCTR2000029749 ( ChiCTR, www.chictr.org.cn )

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