scholarly journals Tandem mass spectrometry of small-molecule antiviral drugs: 3. antiviral agents against herpes, influenza and other viral infections

2020 ◽  
Vol 455 ◽  
pp. 116377 ◽  
Author(s):  
W.M.A. Niessen
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Small Molecule ◽  
Viral Infections ◽  
Antiviral Agents ◽  
Antiviral Drugs ◽  
Tandem Mass

scholarly journals A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

2018 ◽  
Author(s):  
Andrea LA Wong ◽  
Xiaoqiang Xiang ◽  
Pei Shi Ong ◽  
Qin Ying Mitchell Ee ◽  
Nicholas Syn ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Anticancer Drugs ◽  
Small Molecule ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Rapid Quantification

In the last decade, the tremendous improvement in the sensitivity and also affordability of Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) have revolutionized its application in pharmaceutical analysis, resulting in wide-spread of employing LC-MS/MS for determining pharmaceutical compounds including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical Pharmacokinetic studies in R & D of oncology drugs. This mini-review article will describe the state-of-the art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation and matrix effect evaluation.

X-Rank: A Robust Algorithm for Small Molecule Identification Using Tandem Mass Spectrometry

2009 ◽  
Vol 81 (18) ◽  
pp. 7604-7610 ◽  
Author(s):  
Roman Mylonas ◽  
Yann Mauron ◽  
Alexandre Masselot ◽  
Pierre-Alain Binz ◽  
Nicolas Budin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Small Molecule ◽  
Tandem Mass ◽  
Robust Algorithm
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