Optimization of a spray drying process to prepare dry powder microparticles containing plasmid nanocomplex

2012 ◽  
Vol 423 (2) ◽  
pp. 577-585 ◽  
Author(s):  
N. Mohajel ◽  
A. Roholamini Najafabadi ◽  
K. Azadmanesh ◽  
A. Vatanara ◽  
E. Moazeni ◽  
...  
Keyword(s):  
Spray Drying ◽  
Drying Process ◽  
Dry Powder

Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying process

2019 ◽  
Vol 24 (5) ◽  
pp. 584-592 ◽  
Author(s):  
Mahdieh Farhangi ◽  
Arash Mahboubi ◽  
Farzad Kobarfard ◽  
Alireza Vatanara ◽  
Seyed Alireza Mortazavi
Keyword(s):  
Spray Drying ◽  
Dry Powder Inhaler ◽  
Drying Process ◽  
Dry Powder

scholarly journals Optimization of inulin production process parameters using response surface methodology

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Wasim Akram ◽  
Navneet Garud
Keyword(s):  
Response Surface ◽  
Spray Drying ◽  
Product Yield ◽  
Drying Methods ◽  
Process Variables ◽  
Drying Process ◽  
Uniform Size ◽  
Drying Temperature ◽  
Yield Value ◽  
Internal Configuration

Abstract Background Chicory is one of the major source of inulin. In our study, Box–Behnken model/response surface analysis (RSM) was used for the optimization of spray drying process variables to get the maximum inulin yield from chicory (Cichorium intybus L.). For this investigation, the investigational plan utilized three process variables drying temperature (115–125 °C), creep speed (20–24 rpm), and pressure (0.02–0.04 MPa). Result The optimal variables established by applying the Box–Behnken model were as follows: drying temperature 119.20 °C, creep speed 21.64 rpm, and pressure 0.03 MPa. The obtained powdered inulin by spray drying was investigated for the yield value, identification, size, and surface morphology of the particle. The inulin obtained from the spray drying process consists of a fine molecule-sized white powder. Instead, the drying methods shows a significant effect on the morphology and internal configuration of the powdered inulin, as the inulin obtained from spray drying was of a widespread and uniform size and shape, with a rough surface on increase in temperature and smoother surface while increasing the creep speed. The findings indicate that the spray drying with optimum parameters resulted in maximum product yield. Conclusion The outcomes of the study concluded that the product yield through spray drying technique under optimized condition is optimal as compared to other drying technique. Hence, this technique may be applied at commercial scale for the production of inulin.

Quality by design approach in the optimization of the spray-drying process

2011 ◽  
Vol 17 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Arnaud Baldinger ◽  
Lucas Clerdent ◽  
Jukka Rantanen ◽  
Mingshi Yang ◽  
Holger Grohganz
Keyword(s):  
Spray Drying ◽  
Quality By Design ◽  
Design Approach ◽  
Drying Process ◽  
Quality By Design Approach

Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery

2021 ◽  
Vol 14 (4) ◽  
pp. 5538-5548
Author(s):  
Aliasgar J Kundawala ◽  
Khushbu S Chauhan ◽  
Harsha V Patel ◽  
Swati K Kurtkoti
Keyword(s):  
Drug Release ◽  
Spray Drying ◽  
Entrapment Efficiency ◽  
Geometric Standard Deviation ◽  
Drying Method ◽  
Dry Powder ◽  
Liposomal Drug ◽  
Vesicle Size ◽  
Aerodynamic Properties ◽  
Spray Dried

Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by either spray drying liposomal drug suspension or lipid drug suspension. The liposomes were initially prepared by solvent evaporation method using Hydrogenated Soyabean Phosphatidylcholine and Cholesterol (1:1, 1:2, 2:1) as lipid carrier and then spray dried later with mannitol as bulking agent at different lipid to diluent ratio (1:1.25, 1:2.5 & 1:5). The liposomes and liposomal dry powder were evaluated for vesicle size, % entrapment efficiency, in vitro drug release studies, powder characteristics, aerosol performance and stability studies. The liposomes prepared showed vesicle size (2-8 µm), Entrapment efficiency (92.22%) at lipid: drug ratio of (2.5:1) and observed 80.41 % drug release in 24 hrs. Pro-liposomes prepared by spray drying of liposomal drug suspension (LSD1) showed emitted dose, mean mass aerodynamic diameter, geometric standard deviation and fine particle fraction of 99.01%, 3.12 µm, 1.78 and 43.5% along with good powder properties. The spray dried powder was found to be stable at 4 ± 2 °C & 65% ± 5 % RH. The inhalable microparticles containing Budesonide containing lipid dry powder was successfully prepared by spray drying method that showed good aerodynamic properties and stability with mannitol as diluent. The microparticles produced with this novel approach could deliver drug on target via inhalation route and also ease manufacture process at large scale in fewer production steps.

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