A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid–polymer hybrid nanoparticles

2012 ◽  
Vol 424 (1-2) ◽  
pp. 98-106 ◽  
Author(s):  
Yajie Wang ◽  
Katherine Kho ◽  
Wean Sin Cheow ◽  
Kunn Hadinoto
Keyword(s):  
Spray Drying ◽  
Freeze Drying ◽  
Dry Powder Inhaler ◽  
Hybrid Nanoparticles ◽  
Dry Powder ◽  
Polymer Hybrid ◽  
Spray Freeze Drying

scholarly journals Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Changjiao Gan ◽  
Wenbo Luo ◽  
Yunzhou Yu ◽  
Zhouguang Jiao ◽  
Sha Li ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Clostridium Botulinum ◽  
Freeze Drying ◽  
Botulinum Neurotoxin ◽  
Secretory Iga ◽  
Immune Protection ◽  
Dry Powder ◽  
Botulinum Neurotoxin A ◽  
Spray Freeze Drying

AbstractBotulinum neurotoxin (BoNT), produced by Clostridium botulinum, is generally known to be the most poisonous of all biological toxins. In this study, we evaluate the protection conferred by intratracheal (i.t.) inoculation immunization with recombinant Hc subunit (AHc) vaccines against aerosolized BoNT/A intoxication. Three AHc vaccine formulations, i.e., conventional liquid, dry powder produced by spray freeze drying, and AHc dry powder reconstituted in water are prepared, and mice are immunized via i.t. inoculation or subcutaneous (s.c.) injection. Compared with s.c.-AHc-immunized mice, i.t.-AHc-immunized mice exhibit a slightly stronger protection against a challenge with 30,000× LD50 aerosolized BoNT/A. Of note, only i.t.-AHc induces a significantly higher level of toxin-neutralizing mucosal secretory IgA (SIgA) production in the bronchoalveolar lavage of mice. In conclusion, our study demonstrates that the immune protection conferred by the three formulations of AHc is comparable, while i.t. immunization of AHc is superior to s.c. immunization against aerosolized BoNT/A intoxication.

Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying process

2019 ◽  
Vol 24 (5) ◽  
pp. 584-592 ◽  
Author(s):  
Mahdieh Farhangi ◽  
Arash Mahboubi ◽  
Farzad Kobarfard ◽  
Alireza Vatanara ◽  
Seyed Alireza Mortazavi
Keyword(s):  
Spray Drying ◽  
Dry Powder Inhaler ◽  
Drying Process ◽  
Dry Powder

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

2019 ◽  
Vol 36 (10) ◽  
Author(s):  
Cypriane Dormenval ◽  
Abhijeet Lokras ◽  
Guillermo Cano-Garcia ◽  
Abishek Wadhwa ◽  
Kaushik Thanki ◽  
...  
Keyword(s):  
Spray Drying ◽  
Small Interfering Rna ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Interfering Rna
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