Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs

2013 ◽  
Vol 441 (1-2) ◽  
pp. 654-664 ◽  
Author(s):  
Li Zhang ◽  
Jing Yao ◽  
Jianping Zhou ◽  
Tao Wang ◽  
Qiang Zhang
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Glycyrrhetinic Acid ◽  
Antitumor Drugs ◽  
Acid Conjugate

scholarly journals Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 321
Author(s):  
Shenghui Zhong ◽  
Peng Liu ◽  
Jinsong Ding ◽  
Wenhu Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
High Dose ◽  
One Pot ◽  
Inflammatory Site ◽  
Pei Nanoparticles ◽  
Toxic Reactions

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.

scholarly journals In-vivo anticancer activity of Curcumin-Hyaluronic acid conjugate

2019 ◽  
Vol 4 (3) ◽  
pp. 85-89
Author(s):  
Manjunatha P. Mudagal ◽  
Suresh Janadri ◽  
Nageena Taj
Keyword(s):  
Hyaluronic Acid ◽  
Anticancer Activity ◽  
Acid Conjugate

Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel

2020 ◽  
Vol 34 (10) ◽  
pp. 1458-1469 ◽  
Author(s):  
Jiyang Liu ◽  
Na Liang ◽  
Shupeng Li ◽  
Yang Han ◽  
Pengfei Yan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Targeting ◽  
Acid Conjugate

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

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