Application of halloysite clay nanotubes as a pharmaceutical excipient

Background: Preterm birth (PTB), or birth that occurs before 37 weeks of gestation, accounts for the majority of perinatal morbidity and mortality. As of 2016, PTB has an occurrence rate of 9.6% in the United States and accounts for up to 18 percent of births worldwide. Inflammation has been identified as the most common cause of PTB, but effective pharmacotherapy has yet to be developed to prevent inflammation driven PTB. Our group has discovered that N,N-dimethylacetamide (DMA), a readily available solvent commonly used as a pharmaceutical excipient, rescues lipopolysaccharide (LPS)-induced timed pregnant mice from PTB. Methods: We have used in vivo, ex vivo and in vitro approaches to investigate this compound further. Results: Interestingly, we found that DMA suppresses cytokine secretion by inhibiting nuclear factor-kappa B (NF-κB). In ongoing work in this exciting line of investigation, we are currently investigating structural analogs of DMA, some of them novel, to optimize this approach focused on the inflammation associated with PTB. Conclusion: Successful development of pharmacotherapy for the prevention of PTB rests upon the pursuit of multiple strategies to solve this important clinical challenge.

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Physicochemical and Antimicrobial Properties of Cocoa Pod Husk Pectin Intended as a Versatile Pharmaceutical Excipient and Nutraceutical

Journal of Pharmaceutics ◽

10.1155/2016/7608693 ◽

2016 ◽

Vol 2016 ◽

pp. 1-12 ◽

Cited By ~ 8

Author(s):

Ofosua Adi-Dako ◽

Kwabena Ofori-Kwakye ◽

Samuel Frimpong Manso ◽

Mariam EL Boakye-Gyasi ◽

Clement Sasu ◽

...

Keyword(s):

Aqueous Media ◽

Antimicrobial Properties ◽

Microbiological Quality ◽

Elemental Content ◽

Moderate Activity ◽

Pharmaceutical Excipient ◽

E Coli ◽

Swelling Capacity ◽

Weak Activity ◽

Cocoa Pod Husk

The physicochemical and antimicrobial properties of cocoa pod husk (CPH) pectin intended as a versatile pharmaceutical excipient and nutraceutical were studied. Properties investigated include pH, moisture content, ash values, swelling index, viscosity, degree of esterification (DE), flow properties, SEM, FTIR, NMR, and elemental content. Antimicrobial screening and determination of MICs against test microorganisms were undertaken using agar diffusion and broth dilution methods, respectively. CPH pectin had a DE of 26.8% and exhibited good physicochemical properties. Pectin had good microbiological quality and exhibited pseudoplastic, shear thinning behaviour, and high swelling capacity in aqueous media. The DE, FTIR, and NMR results were similar to those of previous studies and supported highly acetylated low methoxy pectin. CPH pectin was found to be a rich source of minerals and has potential as a nutraceutical. Pectin showed dose-dependent moderate activity against gram positive and gram negative microorganisms but weak activity against Listeria spp. and A. niger. The MICs of pectin ranged from 0.5 to 4.0 mg/mL, with the highest activity against E. coli and S. aureus (MIC: 0.5–1.0 mg/mL) and the lowest activity against A. niger (MIC: 2.0–4.0 mg/mL). The study has demonstrated that CPH pectin possesses the requisite properties for use as a nutraceutical and functional pharmaceutical excipient.

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Resin-based dental materials containing 3-aminopropyltriethoxysilane modified halloysite-clay nanotubes for extended drug delivery

Dental Materials ◽

10.1016/j.dental.2020.12.011 ◽

2021 ◽

Vol 37 (3) ◽

pp. 508-515

Author(s):

Ashley Karczewski ◽

Sara Kalagi ◽

Ítallo Emídio Lira Viana ◽

Victor Mota Martins ◽

Simone Duarte ◽

...

Keyword(s):

Drug Delivery ◽

Dental Materials ◽

Clay Nanotubes

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Nanotechnology as an Anti-Infection Strategy in Periprosthetic Joint Infections (PJI)

Tropical Medicine and Infectious Disease ◽

10.3390/tropicalmed6020091 ◽

2021 ◽

Vol 6 (2) ◽

pp. 91

Author(s):

Pier Francesco Indelli ◽

Stefano Ghirardelli ◽

Ferdinando Iannotti ◽

Alessia Maria Indelli ◽

Gennaro Pipino

Keyword(s):

Joint Infection ◽

Treatment Strategies ◽

High Morbidity ◽

Treatment Protocols ◽

Joint Infections ◽

Prevention And Treatment ◽

Efficient Control ◽

Cement Joint ◽

Clay Nanotubes

Background: Periprosthetic joint infection (PJI) represents a devastating consequence of total joint arthroplasty (TJA) because of its high morbidity and its high impact on patient quality of life. The lack of standardized preventive and treatment strategies is a major challenge for arthroplasty surgeons. The purpose of this article was to explore the potential and future uses of nanotechnology as a tool for the prevention and treatment of PJI. Methods: Multiple review articles from the PubMed, Scopus and Google Scholar databases were reviewed in order to establish the current efficacy of nanotechnology in PJI preventive or therapeutic scenarios. Results: As a prevention tool, anti-biofilm implants equipped with nanoparticles (silver, silk fibroin, poly nanofibers, nanophase selenium) have shown promising antibacterial functionality. As a therapeutic tool, drug-loaded nanomolecules have been created and a wide variety of carrier materials (chitosan, titanium, calcium phosphate) have shown precise drug targeting and efficient control of drug release. Other nanotechnology-based antibiotic carriers (lipid nanoparticles, silica, clay nanotubes), when added to common bone cements, enhanced prolonged drug delivery, making this technology promising for the creation of antibiotic-added cement joint spacers. Conclusion: Although still in its infancy, nanotechnology has the potential to revolutionize prevention and treatment protocols of PJI. Nevertheless, extensive basic science and clinical research will be needed to investigate the potential toxicities of nanoparticles.

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Poly(amidoamine) Dendrimers as a Pharmaceutical Excipient. Are We There yet?

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.10.011 ◽

2018 ◽

Vol 107 (1) ◽

pp. 75-83 ◽

Cited By ~ 23

Author(s):

Daniel P. Otto ◽

Melgardt M. de Villiers

Keyword(s):

Pharmaceutical Excipient

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Use of sorbitol as pharmaceutical excipient in the present day formulations – issues and challenges for drug absorption and bioavailability

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2019.1640722 ◽

2019 ◽

Vol 45 (9) ◽

pp. 1421-1429 ◽

Cited By ~ 4

Author(s):

Ranjeet Prasad Dash ◽

Nuggehally R. Srinivas ◽

R. Jayachandra Babu

Keyword(s):

Drug Absorption ◽

Pharmaceutical Excipient

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New multifunctional pharmaceutical excipient in tablet formulation based on citric acid-cyclodextrin polymer

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2016.07.059 ◽

2016 ◽

Vol 511 (2) ◽

pp. 913-920 ◽

Cited By ~ 20

Author(s):

Maria José Garcia-Fernandez ◽

Nicolas Tabary ◽

Feng Chai ◽

Frédéric Cazaux ◽

Nicolas Blanchemain ◽

...

Keyword(s):

Citric Acid ◽

Tablet Formulation ◽

Pharmaceutical Excipient ◽

Cyclodextrin Polymer

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Magnetic halloysite nanotubes for yeast cell surface engineering

Clay Minerals ◽

10.1180/claymin.2016.051.3.07 ◽

2016 ◽

Vol 51 (3) ◽

pp. 429-433 ◽

Cited By ~ 16

Author(s):

S.A. Konnova ◽

Y.M. Lvov ◽

R.F. Fakhrullin

Keyword(s):

Surface Engineering ◽

Halloysite Nanotubes ◽

Yeast Cells ◽

Biological Cells ◽

Intrinsic Properties ◽

Cell Surface Engineering ◽

Yeast Cell Surface ◽

Clay Nanotubes ◽

Field Manipulation ◽

Tube Shell

AbstractHalloysite clay nanotubes are safe and biocompatible nanomaterials and their application in biomaterials is very promising. The microencapsulation of yeast cells in the shell of clay nanotubes modifying their properties was demonstrated here. Each cell was coated with a 200–300 nm-thick tube shell and this coating was not harmful for these cells’ reproduction. Synthesis of magnetic nanoparticles on the surfaces of the nanotubes allowed for magnetic-field manipulation of the coated cells, including their separation. Providing nano-designed shells for biological cells is a step forward in development of ‘cyborg’ microorganisms combining their intrinsic properties with functions added through nano-engineering.

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