Provesicular elastic carriers of Simvastatin for enhanced wound healing activity: An in-vitro/in-vivo study

Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. Recently, it was shown that the essential oil (EO) of B. morelensis has wound healing activity, accelerating cutaneous wound closure and generating scars with good tensile strength. α-pinene (PIN) and α-phellandrene (FEL) are terpenes that have been found in this EO, and it has been shown in different studies that both have anti-inflammatory activity. The aim of this study was to determine the wound healing activity of these two terpenes. The results of in vitro tests demonstrate that PIN and FEL are not cytotoxic at low concentrations and that they do not stimulate fibroblast cell proliferation. In vivo tests showed that the terpenes produce stress-resistant scars and accelerate wound contraction, due to collagen deposition from the early stages, in wounds treated with both terpenes. Therefore, we conclude that both α-pinene and α-phellandrene promote the healing process; this confirms the healing activity of the EO of B. morelensis, since having these terpenes as part of its chemical composition explains part of its demonstrated activity.

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Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation

Artificial Cells Nanomedicine and Biotechnology ◽

10.1080/21691401.2017.1358731 ◽

2017 ◽

Vol 46 (5) ◽

pp. 1009-1017 ◽

Cited By ~ 21

Author(s):

Mrinalini Sharma ◽

Khageswar Sahu ◽

Surya Prakash Singh ◽

Beena Jain

Keyword(s):

Wound Healing ◽

Hyaluronic Acid ◽

In Vivo Evaluation ◽

Wound Healing Activity

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Preparation and characterization of succinyl chitosan and succinyl chitosan nanoparticle film: In vitro and in vivo evaluation of wound healing activity

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.11.015 ◽

2021 ◽

Author(s):

N.T. Thu Thao ◽

H.M.S.M. Wijerathna ◽

R. Saravana Kumar ◽

Dongrack Choi ◽

S.H.S. Dananjaya ◽

...

Keyword(s):

Wound Healing ◽

In Vivo Evaluation ◽

Chitosan Nanoparticle ◽

Wound Healing Activity ◽

Nanoparticle Film

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Wound Healing Activity of Carbonized Rice Husk

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.602-604.1196 ◽

2012 ◽

Vol 602-604 ◽

pp. 1196-1199

Author(s):

Nuraly Akimbekov ◽

Zulhair A. Mansurov ◽

J. Jandosov ◽

Ilya E. Digel ◽

Mathias Gossmann ◽

...

Keyword(s):

Wound Healing ◽

Rice Husk ◽

Dermal Fibroblasts ◽

Human Dermal Fibroblasts ◽

Rat Skin ◽

Cellular Behavior ◽

Proliferation In Vitro ◽

Wound Healing Activity

The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.

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