A micro-extrusion 3D printing platform for fabrication of orodispersible printlets for pediatric use

Author(s):  
Díaz-Torres Eduardo ◽  
Santoveña-Estévez Ana ◽  
Fariña José B
Keyword(s):  
2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.


2021 ◽  
Vol 594 ◽  
pp. 120118
Author(s):  
Tatsuaki Tagami ◽  
Erina Ito ◽  
Risako Kida ◽  
Kiyomi Hirose ◽  
Takehiro Noda ◽  
...  

Nature ◽  
2013 ◽  
Vol 494 (7436) ◽  
pp. 174-174 ◽  
Author(s):  
Michael Pawlyn
Keyword(s):  

Nature ◽  
2020 ◽  
Vol 588 (7839) ◽  
pp. 594-595
Author(s):  
Cameron Darkes-Burkey ◽  
Robert F. Shepherd
Keyword(s):  

Author(s):  
Thomas Birtchnell ◽  
William Hoyle
Keyword(s):  

2018 ◽  
Vol 4 (2) ◽  
pp. 85-90
Author(s):  
Y. M. Dovydenko ◽  
N. A. Ivanova ◽  
S. A. Chizhik ◽  
V. E. Agabekov

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